dusp14
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  • Official Full Name
  • dual specificity phosphatase 14
  • Background
  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14;contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP;(mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009;(PubMed 19228121)).
  • Synonyms
  • DUSP14; dual specificity phosphatase 14; dual specificity protein phosphatase 14; MKP 1 like protein tyrosine phosphatase; MKP L; MKP6; MKP-6; MAP kinase phosphatase 6; MKP-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; mito
Cat.#:DUSP14-2928HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUSP14 Protein, GST-tagged
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Cat.#:DUSP14-2511HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP14, His & MBP tagged
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Cat.#:DUSP14-28072THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP14, T7 -tagged
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Cat.#:DUSP14-853HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP14, T7-tagged
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Cat.#:DUSP14-1349RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DUSP14 Protein, His-tagged
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Cat.#:DUSP14-1570ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP14
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Cat.#:DUSP14-6781HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUSP14 293 Cell Lysate
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Involved Pathway

DUSP14 involved in several pathways and played different roles in them. We selected most pathways DUSP14 participated on our site, such as Hypertrophy Model, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hypertrophy Model
DUSP14; IFRD1; CYR61; MYOG; ADAM10A; MSTNB; JUND; WDR1; ZEB1B; MSTN

Protein Function

DUSP14 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP14 itself. We selected most functions DUSP14 had, and list some proteins which have the same functions with DUSP14. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein DUSP2; SACM1LA; DUSP7; CTDSPL2B; DUSP6; DUSP18; DUSP5; SGPP2; DUSP14; DUSP4
Function poly(A) RNA binding
Related Protein SF3B4; MSI1; KIAA0020; TFRC; SRP54; SYNCRIP; TES; RPUSD4; MYEF2; CSNK1E
Function protein binding
Related Protein RANBP6; GLI3; CTLA4; GOLPH3; PCSK5; GSN; PTRH1; CENPT; SELE; FES
Function protein tyrosine phosphatase activity
Related Protein PTPN11A; SSH3; PTEN; KIAA1274; LRP8; DUSP28; MTM1; PTPN2A; PTENB; DUSP18
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein SSH1; DUSP23; SACM1L; CTDSPL2A; MTMR2; DUSP13; SSH2B; PTP4A2A; DUSP1; NT5DC3

Interacting Protein

DUSP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP14.
SPERT; ISYNA1