DUSP19 Protein, dual specificity phosphatase 19

DUSP19

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DUSP19

Official Full Name dual specificity phosphatase 19
Background Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19;contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by;alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of;DUSPs (see MIM 600714) (summary by Patterson et al., 2009 (PubMed 19228121)).
Synonyms DUSP19; dual specificity phosphatase 19; dual specificity protein phosphatase 19; DUSP17; SKRP1; Dual specificity phosphatase TS DSP1; Dual specificity phosphatase TS-DSP1; DUS19_HUMAN; DUSP 17; DUSP 19; LMW DSP3; LMW-DSP3; LMWDSP 3; LMWDSP3; Low molecular weight dual specificity phosphatase 3; MGC138210; Protein phosphatase SKRP1; SAPK pathway regulating phosphatase 1; SAPK pathway-regulating phosphatase 1; SKRP 1; Stress activated protein kinase pathway regulating phosphatase 1; Stress-activated protein kinase pathway-regulating phosphatase 1; TS DSP1; TS-DSP1
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP19-12211H Recombinant Human DUSP19, GST-tagged E.coli GST
    Human DUSP19-1317H Recombinant Human Dual Specificity Phosphatase 19, His-tagged E.coli His
    Human DUSP19-28073TH Recombinant Human DUSP19, His-tagged His
    Human DUSP19-2932H Recombinant Human DUSP19 Protein, GST-tagged Wheat Germ GST
    Human DUSP19-6779HCL Recombinant Human DUSP19 293 Cell Lysate HEK293 N/A
    Rhesus Macaque DUSP19-1351R Recombinant Rhesus monkey DUSP19 Protein, His-tagged Mammalian Cell His

    DUSP19 involved in several pathways and played different roles in them. We selected most pathways DUSP19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    DUSP19 has several biochemical functions, for example, JUN kinase phosphatase activity, MAP-kinase scaffold activity, mitogen-activated protein kinase kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP19 itself. We selected most functions DUSP19 had, and list some proteins which have the same functions with DUSP19. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase phosphatase activity NT5DC3; SACM1L; SACM1LB; PXYLP1; SGPP2; SACM1LA; TENC1; CTDSPL2B; DUSP19; CTDSPL2A
    MAP-kinase scaffold activity CD36; MAPK8IP3; KSR1; SPAG9; MAPK8IP2; DUSP19; SPAG9A; JIP1
    mitogen-activated protein kinase kinase kinase binding MARVELD3; MAPK8IP3; MAPK1; TRAF6; TRAF2; TCF3; PPEF2; CDC37; MAP3K11; DUSP19
    protein binding PRSS3; IVL; CD200; RTF1; CALM3; MAP3K7IP3; IP6K2; NPHP3; FAM212A; CASP2
    protein kinase activator activity STRADA; NKX3; TOM1L1; MARK2; DAXX; FAM58A; NCKAP1L; EPO; AGAP2; MAPK8IP2
    protein kinase inhibitor activity JIP1; SH3BP5LA; TAOK3; NPM1; CD36; PRKRIP1; SOCS1; GMFG; SOCS5B; CAMK2N1A
    protein tyrosine phosphatase activity DUSP23; DUSP11; PTPRZ1; DUSP22A; DNAJC6; DUSP22B; TPTE; DUSP21; PTPN23; PTPRJ
    protein tyrosine/threonine phosphatase activity SACM1LB; DUSP2; SACM1LA; DUSP1; SACM1L; PXYLP1; PTPRQ; CTDSPL2B; TENC1; NT5DC3

    DUSP19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP19 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP19.

    ALAS1

    Ma, JJ; Yu, XY; et al. DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma. ONCOLOGY LETTERS 6:1624-1630(2013).
    Cagnol, S; Rivard, N; et al. Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. ONCOGENE 32:564-576(2013).

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