dusp4
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  • Official Full Name
  • dual specificity phosphatase 4
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
  • Synonyms
  • DUSP4; dual specificity phosphatase 4; dual specificity protein phosphatase 4; HVH2; MAP kinase phosphatase 2; MKP 2; TYP; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; serine/threonine specific protein phosphatase; mitogen-acti
Cat.#:DUSP4-101HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DUSP4, GST-tagged
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Cat.#:DUSP4-4890MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DUSP4 Protein
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Cat.#:DUSP4-1976RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DUSP4 Protein
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Cat.#:DUSP4-6401CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DUSP4
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Cat.#:DUSP4-11388ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP4
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Cat.#:DUSP4-6773HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUSP4 293 Cell Lysate
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Cat.#:DUSP4-6774HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUSP4 293 Cell Lysate
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Involved Pathway

DUSP4 involved in several pathways and played different roles in them. We selected most pathways DUSP4 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
SPTBN2; DUSP10; HBEGF; PSMD10; EGF; PEBP1; PEA15A; FRS3; CSF2RA; JAK3
Activated TLR4 signalling
UBE2V1; PELI2; NOD1; MAP3K8; MAPKAPK2B; TNIP2; SIGIRR; DUSP7; RIPK3; DUSP4
Axon guidance
DUSP5; PEBP1; ROCK1; SPNA1; EPHA4; PAK7; EPHA2A; FGFR1B; SEMA6C; SEMA4C
B Cell Receptor Signaling Pathway
CD19; BLK; PPP3CC; CR2; MAP4K1; CD79B; NFKBIB; KRAS; INPPL1; NFKB1
Cytokine Signaling in Immune system
IRF4; IRF2; EIF4G2; TNFSF13B; NUP35; RASGRP1; UBE2L6; DUSP1; TRIM2; PHB
DAP12 interactions
JAK3; SPRED1; SPRED2; PTPRA; PHB; FRS3; LAMTOR2; GRAP2B; SPTBN1; SPTA1
DAP12 signaling
MARK3; DUSP7; DUSP10; CSF2RB; SPNA1; KLB; PHB; FGF18B; PAQR3B; SPTA1
Developmental Biology
DUSP4; COL6A2; FGFR1B; SALL4; KCNQ2; TCF3A; DNM1; CFC1; MED29; CHL1

Protein Function

DUSP4 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP4 itself. We selected most functions DUSP4 had, and list some proteins which have the same functions with DUSP4. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein PXYLP1; DUSP21; PTPRQ; DUSP7; DUSP14; SACM1LA; DUSP10; DUSP2; DUSP8A; DUSP4
Function protein tyrosine phosphatase activity
Related Protein DUSP3; DUSP14; KIAA1274; DUSP13; EVLA; PTEN; PTPRUB; PTPRQ; SSH3; PTENB
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein CDC14AB; DUSP19B; SACM1L; SSH2; CDC14C; SACM1LA; PTENB; PXYLP1; DUSP22A; DUSP23
Function protein tyrosine/threonine phosphatase activity
Related Protein DUSP4; DUSP1; TENC1; PTPRQ; PXYLP1; CTDSPL2A; SACM1LA; NT5DC3; SGPP2; DUSP2

Interacting Protein

DUSP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP4.
MAPK1; MAPK9; MAPK8; MAPK14; CRMP1; MAPK1