dusp6
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  • Official Full Name
  • dual specificity phosphatase 6
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • DUSP6; dual specificity phosphatase 6; dual specificity protein phosphatase 6; MKP 3; PYST1; MAP kinase phosphatase 3; dual specificity protein phosphatase PYST1; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase
Cat.#:DUSP6-2945HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUSP6 Protein, GST-tagged
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Cat.#:DUSP6-384HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP6 Protein, His-tagged
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Cat.#:DUSP6-12218HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP6, GST-tagged
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Cat.#:DUSP6-631HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DUSP6
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Cat.#:DUSP6-666HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP6, GST-tagged
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Cat.#:DUSP6-4892MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DUSP6 Protein
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Cat.#:DUSP6-1978RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DUSP6 Protein
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Cat.#:DUSP6-1356RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DUSP6 Protein, His-tagged
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Cat.#:DUSP6-5925CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DUSP6
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Cat.#:DUSP6-9730ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP6
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Cat.#:DUSP6-6770HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUSP6 293 Cell Lysate
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Involved Pathway

DUSP6 involved in several pathways and played different roles in them. We selected most pathways DUSP6 participated on our site, such as ARMS-mediated activation, Activated TLR4 signalling, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
NTF7; SPNA1; SLC14A2; PEA15A; SPTBN2; AKAP9; NRG3; CSF2RA; CSK; DUSP10
Activated TLR4 signalling
TAB1; TIRAP; PELI2; IRAK3; CHUK; TANK; CREB1; ALCAMB; DUSP6; CREB1B
Axon guidance
PLXNB2; NADL1.1; CNKSR1; DLG3; ROBO1; SEMA3AA; COL9A1A; SEMA3E; JAK3; PAQR3B
B Cell Receptor Signaling Pathway
CARD11; PPP3CB; TTC6; PIK3CD; PIK3R3; FOS; PILRB; RAC2; PIK3CA; PDK2B
Cytokine Signaling in Immune system
SPTA1; TRIM31; IRF6; EDAR; GBP2; SPTBN1; RASGEF1A; DUSP2; LAMTOR2; TRIM5
DAP12 interactions
SPNA2; HBEGF; FGF18B; GRAP2B; SPRED1; NRG4; PEA15A; TRAT1; MOV10; PRKAR1AA
DAP12 signaling
CSF2RB; PTPRA; RASGRP4; SPRED2; PRKAR1AA; SPTB; FRS2A; RASGEF1A; LAMTOR2; GRAP2A
Developmental Biology
DUSP1; SPRED1; EZRA; MED29; CRMP1; HFE2; COL6A1; EFNA4; CEBPA; ST8SIA2

Protein Function

DUSP6 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP6 itself. We selected most functions DUSP6 had, and list some proteins which have the same functions with DUSP6. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein PXYLP1; DUSP21; DUSP8A; DUSP1; DUSP10; DUSP7; DUSP18; SACM1LA; DUSP14; DUSP16
Function protein tyrosine phosphatase activity
Related Protein DUSP23A; TPTE; PTPRZ1; MTMR1A; EPM2A; PTPRUB; PTPRC; PTPN4A; MTMR14; MTMR2

Interacting Protein

DUSP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP6.
SRPK1; MAPK3; MAPK1; TEX11; MDFI; ZNF212

DUSP6 Related Articles

Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
Dickinson, RJ; Delavaine, L; et al. Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways. JOURNAL OF BIOLOGICAL CHEMISTRY 286:38018-38026(2011).