|Official Full Name||dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A|
|Background||Minibrain (MNBH) is also known as DYRK1 and is the human homolog of the mnb gene in Drosophila and is mapped on human chromosome 21q22.2,Which is within the down syndrome critical region. MNBH may be involved in the signaling pathway that controls cell proliferation and is thought to regulate neuronal differentiation and apoptosis by phosphorylating Hip-1.|
|Synonyms||DYRK1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK, DYRK1, MNBH; dual specificity tyrosine-phosphorylation-regulated kinase 1A; hMNB; MNB/DYRK protein kinase; serine/threonine kinase MNB; mnb protein kinase homolog hp86; protein kinase minibrain homolog; dual specificity YAK1-related kinase; serine/threonine-specific protein kinase; MNB; DYRK; HP86; MNBH; MRD7; DYRK1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
DYRK1A involved in several pathways and played different roles in them. We selected most pathways DYRK1A participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, G0 and Early G1, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cell Cycle||E2F5; TFDP1; CENPO; MCM9; RBL2; CDC27; KIF2C; KIF18A; BRE; ANAPC7|
|Cell Cycle, Mitotic||ESCO2; CDK5RAP2; TUBB4A; FGFR1OP; VRK1; ITGB3BP; TUBGCP3; SDCCAG8; CDKN1B; MYCA|
|G0 and Early G1||DYRK1A; TOP2A; E2F4; MYBL2; LIN9; LIN37; LIN54; LIN52; PIANP|
|Hedgehog Signaling Pathway||PTCH1; GAS1B; PRKACAA; WNT8B; ZIC2A; CSNK1G2; RAB23; GLI2A; WNT9B; WNT8A|
|Mitotic G1-G1/S phases||TOP2A; LIN37; MYCA; DYRK1A; LIN9; LIN54; LIN52; MYBL2|
DYRK1A has several biochemical functions, for example, ATP binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK1A itself. We selected most functions DYRK1A had, and list some proteins which have the same functions with DYRK1A. You can find most of the proteins on our site.
|ATP binding||NMNAT3; ABCC9; LMTK2; G3BP1; JAK3; IP6K3; CLPXA; HSP70L; ACOT12; ATP2B3A|
|identical protein binding||ANXA4; TRIM8; CUBN; DVL1; STAT6; CLDN14; NONO; COL2A1; RAD51; PPPDE2|
|non-membrane spanning protein tyrosine kinase activity||TXK; FYN; STYK1; PTK2BB; STK16; DYRK1A; JAK2B; MELK; TNK2; YES1|
|protein binding||IL18R1; VGLL4; SELS; NRIP1; RFX3; DDB2; ERGIC2; UPRT; CPNE6; CLIC1|
|protein kinase activity||RNASEL; RIPK4; CSNK1G3; CDK9; TGFBR1; HIPK3B; GC2; VRK1; STK24A; STK25A|
|protein self-association||MDH2; CCDC88C; AXIN1; TRP53; L1CAM; AGXT; TMEM190; AGTR1A; CNTN2; ACHE|
|protein serine/threonine kinase activity||TLK1B; CDC42BPG; LMTK3; TSSK4; ROCK2A; NIM1; MAP3K9; TESK1; NEK9; SNRKA|
|protein serine/threonine/tyrosine kinase activity||PRKACA; AURKC; MAP2K2; TTK; TNK2; DYRK1AA; DYRK1A; SGK1; RPS6KB1; AURKA|
|protein tyrosine kinase activity||KDR; FGFR1A; ERBB3B; PTK2B; ZNF143B; EPHA7; EPHB2; EPHB4B; KDRL; DYRK4|
|tau protein binding||DYRK1A; AATF; APOE; BIN1; HDAC6; FKBP4; PPP2R2A; SERPINB1A; SNCA; S100B|
DYRK1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK1A here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK1A.
DCAF7; YWHAG; RB1; RBL1; TROAP; LZTS2; YWHAE