DYRK1A Protein, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

DYRK1A

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DYRK1A

Official Full Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Background Minibrain (MNBH) is also known as DYRK1 and is the human homolog of the mnb gene in Drosophila and is mapped on human chromosome 21q22.2,Which is within the down syndrome critical region. MNBH may be involved in the signaling pathway that controls cell proliferation and is thought to regulate neuronal differentiation and apoptosis by phosphorylating Hip-1.
Synonyms DYRK1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK, DYRK1, MNBH; dual specificity tyrosine-phosphorylation-regulated kinase 1A; hMNB; MNB/DYRK protein kinase; serine/threonine kinase MNB; mnb protein kinase homolog hp86; protein kinase minibrain homolog; dual specificity YAK1-related kinase; serine/threonine-specific protein kinase; MNB; DYRK; HP86; MNBH; MRD7; DYRK1
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DYRK1A-19H Recombinant Human DYRK1A, GST-tagged Insect Cell GST
    Human DYRK1A-227H Recombinant Human DYRK1A, His-tagged E.coli His
    Human DYRK1A-26456TH Recombinant Human DYRK1A Wheat Germ N/A
    Human DYRK1A-2981H Recombinant Human DYRK1A Protein, GST-tagged Insect Cell GST
    Human DYRK1A-2982H Recombinant Human DYRK1A Protein, GST-tagged Wheat Germ GST
    Human DYRK1A-6752HCL Recombinant Human DYRK1A 293 Cell Lysate HEK293 N/A
    Human DYRK1A-776H Recombinant Human DYRK1A Protein, DDK-tagged Sf9 Insect Cell DDK
    Rat DYRK1A-1990R Recombinant Rat Dyrk1a protein, GST-tagged E.coli GST
    Rhesus Macaque DYRK1A-1363R Recombinant Rhesus monkey DYRK1A Protein, His-tagged Mammalian Cell His
    Chicken DYRK1A-6119C Recombinant Chicken DYRK1A Mammalian Cell His

    DYRK1A involved in several pathways and played different roles in them. We selected most pathways DYRK1A participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, G0 and Early G1, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle E2F5; TFDP1; CENPO; MCM9; RBL2; CDC27; KIF2C; KIF18A; BRE; ANAPC7
    Cell Cycle, Mitotic ESCO2; CDK5RAP2; TUBB4A; FGFR1OP; VRK1; ITGB3BP; TUBGCP3; SDCCAG8; CDKN1B; MYCA
    G0 and Early G1 DYRK1A; TOP2A; E2F4; MYBL2; LIN9; LIN37; LIN54; LIN52; PIANP
    Hedgehog Signaling Pathway PTCH1; GAS1B; PRKACAA; WNT8B; ZIC2A; CSNK1G2; RAB23; GLI2A; WNT9B; WNT8A
    Mitotic G1-G1/S phases TOP2A; LIN37; MYCA; DYRK1A; LIN9; LIN54; LIN52; MYBL2

    DYRK1A has several biochemical functions, for example, ATP binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK1A itself. We selected most functions DYRK1A had, and list some proteins which have the same functions with DYRK1A. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NMNAT3; ABCC9; LMTK2; G3BP1; JAK3; IP6K3; CLPXA; HSP70L; ACOT12; ATP2B3A
    identical protein binding ANXA4; TRIM8; CUBN; DVL1; STAT6; CLDN14; NONO; COL2A1; RAD51; PPPDE2
    non-membrane spanning protein tyrosine kinase activity TXK; FYN; STYK1; PTK2BB; STK16; DYRK1A; JAK2B; MELK; TNK2; YES1
    protein binding IL18R1; VGLL4; SELS; NRIP1; RFX3; DDB2; ERGIC2; UPRT; CPNE6; CLIC1
    protein kinase activity RNASEL; RIPK4; CSNK1G3; CDK9; TGFBR1; HIPK3B; GC2; VRK1; STK24A; STK25A
    protein self-association MDH2; CCDC88C; AXIN1; TRP53; L1CAM; AGXT; TMEM190; AGTR1A; CNTN2; ACHE
    protein serine/threonine kinase activity TLK1B; CDC42BPG; LMTK3; TSSK4; ROCK2A; NIM1; MAP3K9; TESK1; NEK9; SNRKA
    protein serine/threonine/tyrosine kinase activity PRKACA; AURKC; MAP2K2; TTK; TNK2; DYRK1AA; DYRK1A; SGK1; RPS6KB1; AURKA
    protein tyrosine kinase activity KDR; FGFR1A; ERBB3B; PTK2B; ZNF143B; EPHA7; EPHB2; EPHB4B; KDRL; DYRK4
    tau protein binding DYRK1A; AATF; APOE; BIN1; HDAC6; FKBP4; PPP2R2A; SERPINB1A; SNCA; S100B

    DYRK1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK1A here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK1A.

    DCAF7; YWHAG; RB1; RBL1; TROAP; LZTS2; YWHAE

    Kida, E; Walus, M; et al. FORM OF DUAL-SPECIFICITY TYROSINE-(Y)-PHOSPHORYLATION-REGULATED KINASE 1A NONPHOSPHORYLATED AT TYROSINE 145 AND 147 IS ENRICHED IN THE NUCLEI OF ASTROGLIAL CELLS, ADULT HIPPOCAMPAL PROGENITORS, AND SOME CHOLINERGIC AXON TERMINALS. NEUROSCIENCE 195:112-127(2011).
    Lilienthal, E; Kolanowski, K; et al. Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes. BMC BIOCHEMISTRY 11:-(2010).

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