e4f1
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  • Official Full Name
  • E4F transcription factor 1
  • Background
  • The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.
  • Synonyms
  • E4F1; E4F transcription factor 1; transcription factor E4F1; E4F; E4F transcription factor 1, isoform CRA_b; P120E4F transcription factor; p50E4F; p120E4F; transcription factor E4F; putative E3 ubiquitin-protein ligase E4F1
Cat.#:E4F1-3011HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E4F1 Protein, GST-tagged
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Cat.#:E4F1-27377THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E4F1, His-tagged
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Cat.#:E4F1-4938MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse E4F1 Protein
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Cat.#:E4F1-1369RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey E4F1 Protein, His-tagged
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Cat.#:E4F1-3132ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish E4F1
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Cat.#:E4F1-522HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human E4F1 cell lysate
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Involved Pathway

E4F1 involved in several pathways and played different roles in them. We selected most pathways E4F1 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with E4F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p53 pathway
E4F1; PPP1R13L; KAT8; RASSF1; NEDD8; HUWE1; CSE1L; TTC5; TRIM28; DYRK2

Protein Function

E4F1 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, cAMP response element binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E4F1 itself. We selected most functions E4F1 had, and list some proteins which have the same functions with E4F1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF35; ZNF524; RPAP1; OTX1B; ZNF74; ZSCAN4D; NR1D1; CROP; RC3H2; C1D
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein MNT; BARX2; PHF21A; DLX2; MYOD1; GATA4; TFAP2D; RELA; HOXD8; TAL2
Function cAMP response element binding
Related Protein ATF2; JUN; CREB3L3L; ATF6B; CREB3; E4F1; CREB3L1; CREB3L3; ATF6; CREB1
Function ligase activity
Related Protein TRAIP; BRAP; MSL2; MID2; TRIM28; TRIM17; UBE2F; HACE1; BIRC2; RNF126
Function metal ion binding
Related Protein MGAT4C; SMYD2A; COL9A1; PDE8B; POLH; Scd1; PDE1A; ZBTB6; DNA2; ZNF180
Function protein binding
Related Protein GIMAP7; ZNF232; PRDX6; DPEP1; IGF2BP1; YOD1; USP28; SULT1B1; MYO9B; HTN1
Function transcription coactivator activity
Related Protein TAF7; RFXAP; MTDH; ARID1A; SMARCA2; TAF12; BIRC2; FUS; ENY2; MKL1
Function transcription corepressor activity
Related Protein EID1; SF1; BCL11A; SRSF2; MSC; CDYL; TBL1XR1A; HEYL; HIRA; FOXP3
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF561; PBX4; MEF2D; ZNF134; NKX6-2; MYCB; ZNF583; TCEAL1; ZFP82; SOX4
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ETV6; ISX; POU5F1; ZBTB12.2; ASCL3; ARID5B; SATB1; VAX2; VAX1; ZNF350

Interacting Protein

E4F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E4F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of E4F1.
RASSF1; gam1_adeg1; ANP32A; lnx2b; X