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  • Official Full Name
  • ectodysplasin A receptor
  • Background
  • EDAR is a 49 kDa novel receptor of the TNFR family with one phosphorylation site at serine 324 residue and one death domain near the C-terminus (358-431 aa). Mutations in EDAR have been found in several families with autosomal hypohidrotic ectodermal dysp
  • Synonyms
  • EDAR; ectodysplasin A receptor; DL, ectodysplasin 1, anhidrotic receptor , ED3; tumor necrosis factor receptor superfamily member EDAR; ED1R; ED5; EDA1R; EDA3; EDA-A1 receptor; downless homolog; ectodysplasin-A receptor; downless, mouse, homolog of
Cat.#:EDAR-3047HTag:His|Flag|StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human EDAR Protein, His/Flag/StrepII-tagged
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Cat.#:EDAR-3049HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EDAR Protein, GST-tagged
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Cat.#:EDAR-921HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EDAR Protein, MYC/DDK-tagged
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Cat.#:EDAR-12275HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EDAR, GST-tagged
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Cat.#:EDAR-1607HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Ectodysplasin A Receptor
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Cat.#:EDAR-2119HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ectodysplasin A Receptor, Fc Chimera
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Cat.#:EDAR-231HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EDAR, Fc-tagged
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Cat.#:EDAR-3135HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EDAR, Fc tagged
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Cat.#:EDAR-3215HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EDAR, His tagged
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Cat.#:EDAR-601HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human EDAR, Fc-tagged, Biotinylated
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Cat.#:EDAR-606HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ectodysplasin A receptor, His-tagged
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Cat.#:Edar-1721MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ectodysplasin-A Receptor
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Cat.#:EDAR-4981MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EDAR Protein
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Cat.#:Edar-7468RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Edar, Fc tagged
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Cat.#:EDAR-77CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EDAR, His tagged
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Cat.#:EDAR-8833CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EDAR, Fc tagged
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Cat.#:EDAR-1980CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EDAR
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Cat.#:EDAR-6522ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EDAR
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Cat.#:EDAR-2247HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EDAR cell lysate
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Cat.#:EDAR-1537RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EDAR cell lysate
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Cat.#:EDAR-1021CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EDAR cell lysate
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Involved Pathway

EDAR involved in several pathways and played different roles in them. We selected most pathways EDAR participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine Signaling in Immune system
EDAR; LGALS9; TRIM68; TRIM62; CRKL; GBP2; IRAK3; CSF2; TRIM6; DUSP2
Cytokine-cytokine receptor interaction
VEGFB; TNFRSF25; EDA; IFNK; OSM; PDGFA; PPBP; IL17A; TNFSF4; IFNG1-2
Immune System
BTLA; CTSK; RAPGEF3; SEC61B; ACTR2B; OSCAR; KLHL20; ASB18; GRAP2B; AP1G1
Integrated Breast Cancer Pathway
CCNB1IP1; SELK; EDAR; NOXA1; USP16; DCAKD; NAB1; RPP38; C21orf7; AHR
TNFR2 non-canonical NF-kB pathway
EDARADD; EDAR; EDA
TNFs bind their physiological receptors
EDAR; EDA; EDARADD

Protein Function

EDAR has several biochemical functions, for example, protein binding, receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDAR itself. We selected most functions EDAR had, and list some proteins which have the same functions with EDAR. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein LUZP4; EREG; NAA35; MAP3K3; SGK3; C1orf111; CTNNA3; UBE2W; SPG21; KIFC3
Function receptor activity
Related Protein CADM1A; MED24; CSF2RA; CD160; PAQR5B; PVR; OGFRL1; NOTCH1; SEC63; GRIA4A
Function transmembrane signaling receptor activity
Related Protein TLR2; LILRB5; OR12D2; TLR18; NPR2; KLRC3; ANTXR1; CD27; MARCO; P2RX5

Interacting Protein

EDAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDAR here. Most of them are supplied by our site. Hope this information will be useful for your research of EDAR.
Traf1; Traf2; TRAF3; EDARADD; EDA; MAP3K14

EDAR Related Articles

Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).
Hill, G; Headon, D; et al. Pharmacological Activation of the EDA/EDAR Signaling Pathway Restores Salivary Gland Function following Radiation-Induced Damage. PLOS ONE 9:-(2014).

EDAR Related Gene Family

TNF Cytokines