Recombinant Human EDAR Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: EDAR-782H
• Product Overview: EDAR MS Standard C13 and N15-labeled recombinant protein (NP_071731) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.6 kDa
• AA Sequence: MAHVGDCTQTPWLPVLVVSLMCSAR AEYSNCGENEYYNQTTGLCQECPPC GPGEEPYLSCGYGTKDEDYGCVPCP AEKFSKGGYQICRRHKDCEGFFRAT VLTPGDMENDAECGPCLPGYYMLEN RPRNIYGMVCYSCLLAPPNTKECVG ATSGASANFPGTSGSSTLSPFQHAH KELSGQGHLATALIIAMSTIFIMAI AIVLIIMFYILKTKPSAPACCTSHP GKSVEAQVSKDEEKKEAPDNVVMFS EKDEFEKLTATPAKPTKSENDASSE NEQLLSRSVDSDEEPAPDKQGSPEL CLLSLVHLAREKSATSNKSAGIQSR RKKILDVYANVCGVVEGLSPTELPF DCLEKTSRMLSSTYNSEKAVVKTWR HLAESFGLKRDEIGGMTDGMQLFDR ISTAGYSIPELLTKLVQIERLDAVE SLCADILEWAGVVPPASQPHAASTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: EDAR ectodysplasin A receptor [ Homo sapiens (human) ]
• Official Symbol: EDAR
• Synonyms: EDAR; ectodysplasin A receptor; DL, ectodysplasin 1, anhidrotic receptor, ED3; tumor necrosis factor receptor superfamily member EDAR; ED1R; ED5; EDA1R; EDA3; Edar; EDA-A1 receptor; downless homolog; ectodysplasin-A receptor; downless, mouse, homolog of; ectodermal dysplasia receptor; anhidrotic ectodysplasin receptor 1; ectodysplasin 1, anhidrotic receptor; DL; ED3; HRM1; EDA-A1R; FLJ94390
• Gene ID: 10913
• mRNA Refseq: NM_022336
• Protein Refseq: NP_071731
• MIM: 604095
• UniProt ID: Q9UNE0