EGLN1

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EGLN1

Official Full Name egl-9 family hypoxia-inducible factor 1
Background The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
Synonyms EGLN1; egl-9 family hypoxia-inducible factor 1; HPH2; PHD2; SM20; ECYT3; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2; egl nine homolog 1; egl nine-like protein 1; HIF prolyl hydroxylase 2; HIF-prolyl hydroxylase 2; zinc finger MYND domain-containing protein 6; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • FLAG
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EGLN1-001H Recombinan Human EGLN1 protein, FLAG-tagged Insect cells FLAG
    Human EGLN1-4080H Recombinant Human EGLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Egln1-497M Recombinant Mouse Egln1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EGLN1-12325H Recombinant Human EGLN1, GST-tagged E.coli GST
    Human EGLN1-126H Recombinant human EGLN1, GST tagged Wheat Germ GST
    Human EGLN1-127H Recombinant Human EGLN1, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGLN1-414H Recombinant Human EGLN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGLN1-6696HCL Recombinant Human EGLN1 293 Cell Lysate HEK293 N/A
    Mouse EGLN1-5049M Recombinant Mouse EGLN1 Protein Mammalian Cell His

    EGLN1 involved in several pathways and played different roles in them. We selected most pathways EGLN1 participated on our site, such as HIF- signaling pathway, Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HIF- signaling pathway SERPINE1; IL6R; VHL; CUL2; NPPA; INS2; NOX3; PDHA1; PIK3R2; HKDC1
    Pathways in cancer GNAI3; FGF7; RALBP1; TRAF1; STAT5A; FH; PLCB2; RASSF1; NKX3-1; FLT3
    Renal cell carcinoma TCEB1; FH1; PIK3CA; EPAS1; VHL; RAPGEF1; KRAS; MET; PTPN11; FH

    EGLN1 has several biochemical functions, for example, L-ascorbic acid binding, enzyme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN1 itself. We selected most functions EGLN1 had, and list some proteins which have the same functions with EGLN1. You can find most of the proteins on our site.

    Function Related Protein
    L-ascorbic acid binding OGFOD2; EGLN1; P4HA1A; OGFOD3; P4HA1; P4HTM; OGFOD1; LEPREL1; PAM; LEPRE1
    enzyme binding RYR2; HLCS; TMBIM6; PARK2; HSPA8; PRKCE; TH; DHCR24; NKX2-1; BCHE
    iron ion binding P4HA1A; TYW1B; CYP2AA4; CYP4F22; PLOD2; CYP3A4; CYP2AA8; LEPRE1; CYP2AA3; CYP2D26
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors KDM5BA; ALKBH8; KDM5D; P4HTM; EGLN2; TYW5; KDM5B; EGLN1; KDM5BB; HIF1AN
    peptidyl-proline 4-dioxygenase activity EGLN3; EGLN1; EGLN2
    peptidyl-proline dioxygenase activity EGLN1; OGFOD1
    protein binding ABHD1; RAD51C; TRIM26; EFNA3; CEACAM21; GRB2; ERCC6; TET2; LIG3; TRAF7

    EGLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN1.

    HIF1A; FKBP8; EPAS1; OS9; PKM

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