Recombinant Human EGLN1, MYC/DDK-tagged
Cat.No. : | EGLN1-127H |
Product Overview : | Recombinant Human EGLN1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). |
Source : | HEK293 cells |
Species : | Human |
Tag : | MYC/DDK |
Molecular Mass : | 45.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | EGLN1 egl-9 family hypoxia-inducible factor 1 [ Homo sapiens (human) ] |
Official Symbol : | EGLN1 |
Synonyms : | EGLN1; egl nine homolog 1 (C. elegans); C1orf12, EGL nine (C.elegans) homolog 1; egl nine homolog 1; HIF prolyl hydroxylase 2; HIFPH2; PHD2; SM 20; ZMYND6; egl nine-like protein 1; HIF-prolyl hydroxylase 2; zinc finger MYND domain-containing protein 6; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2; HPH2; SM20; ECYT3; HPH-2; C1orf12; HIF-PH2; DKFZp761F179 |
Gene ID : | 54583 |
mRNA Refseq : | NM_022051 |
Protein Refseq : | NP_071334 |
MIM : | 606425 |
UniProt ID : | Q9GZT9 |
Chromosome Location : | 1q42.1 |
Pathway : | Cellular response to hypoxia; HIF-1 signaling pathway; HIF-2-alpha transcription factor network |
Function : | L-ascorbic acid binding; peptidyl-proline 4-dioxygenase activity; peptidyl-proline dioxygenase activity |
Products Types
◆ Recombinant Protein | ||
EGLN1-001H | Recombinant Human EGLN1 protein | +Inquiry |
EGLN1-414H | Recombinant Human EGLN1 Protein, MYC/DDK-tagged | +Inquiry |
EGLN1-2680M | Recombinant Mouse EGLN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Egln1-497M | Recombinant Mouse Egln1 Protein, MYC/DDK-tagged | +Inquiry |
EGLN1-126H | Recombinant human EGLN1, GST tagged | +Inquiry |
◆ Lysates | ||
EGLN1-6696HCL | Recombinant Human EGLN1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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