EGLN2

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EGLN2

Official Full Name egl-9 family hypoxia-inducible factor 2
Background The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]
Synonyms EGLN2; egl-9 family hypoxia-inducible factor 2; EIT6; PHD1; HPH-1; HPH-3; HIFPH1; HIF-PH1; egl nine homolog 2; estrogen-induced tag 6; HIF-prolyl hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase domain-containing protein 1;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EGLN2-4013H Recombinant Human EGLN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Egln2-498M Recombinant Mouse Egln2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EGLN2-3118H Recombinant Human EGLN2 Protein, GST-tagged Wheat Germ GST
    Human EGLN2-399H Recombinant Human EGLN2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGLN2-450H Recombinant Human EGLN2 Protein, His-tagged E.coli His
    Human EGLN2-6694HCL Recombinant Human EGLN2 293 Cell Lysate HEK293 N/A
    Human EGLN2-6695HCL Recombinant Human EGLN2 293 Cell Lysate HEK293 N/A
    Rat EGLN2-2030R Recombinant Rat EGLN2 Protein Mammalian Cell His
    Rhesus Macaque EGLN2-1397R Recombinant Rhesus monkey EGLN2 Protein, His-tagged Mammalian Cell His

    EGLN2 involved in several pathways and played different roles in them. We selected most pathways EGLN2 participated on our site, such as Cellular response to hypoxia, Cellular responses to stress, HIF-1 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular response to hypoxia HIF3A; EGLN1B; HIF1AL; EGLN2; EPAS1B; EGLN3; HIF1AN
    Cellular responses to stress HSBP1; HIST2H3C; TERF2IP; SUZ12B; Txn1; AGO1; HSBP1B; CBX8B; AGO3; EGLN3
    HIF-1 signaling pathway CYBB; EGLN3; EGLN2; AHA-1
    HIF-2-alpha transcription factor network HIF1AN; EGLN3; CITED2; EGLN2
    Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIF1AL; EPAS1B; EGLN3; HIF3A; EGLN2; EGLN1B
    Pathways in cancer PIK3CB; MITF; TRAF3; PRKACA; PDGFB; NTRK1; CCND1; PTGER4; SKP2; CBL
    Regulation of Hypoxia-inducible Factor (HIF) by oxygen EPAS1B; EGLN1B; HIF3A; HIF1AL; EGLN2; EGLN3; HIF1AN
    Renal cell carcinoma PAK6; MAPK3; MAP2K2; EPAS1; PIK3R5; GRB2; FLCN; FH; PAK1; TGFB3

    EGLN2 has several biochemical functions, for example, L-ascorbic acid binding, ferrous iron binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN2 itself. We selected most functions EGLN2 had, and list some proteins which have the same functions with EGLN2. You can find most of the proteins on our site.

    Function Related Protein
    L-ascorbic acid binding PHYH; EGLN1; LEPREL2; P3H2; OGFOD1; EGLN1B; DBH; EGLN3; P4HA2; P4HA1A
    ferrous iron binding ALKBH3; BCO1; UROD; ALKBH1; TF; FTO; ISCUB; ISCA2; Trf; DNAJC24
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors KDM5D; EGLN3; C14orf169; EGLN1; KDM5B; KDM5BA; ALKBH4; ALKBH5; HIF1AN; KDM5BB
    oxygen sensor activity HIF1AN; EGLN2; NOX4
    peptidyl-proline 4-dioxygenase activity EGLN1; EGLN3; EGLN2
    protein binding TNPO2; UBR1; DDX41; TRMT112; PCDHA4; ZNF136; GSTO1; IL1RL1; PRMT1; ZNF69

    EGLN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN2.

    HIF1A; SRPK2; EPAS1; VHL; FAM46A; MOB4

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