eif2ak1
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  • Official Full Name
  • eukaryotic translation initiation factor 2-alpha kinase 1
  • Background
  • The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Synonyms
  • EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; HRI; heme-regulated inhibitor; heme-regulated repressor; heme-controlled repressor; heme sensitive initiation factor 2a kinase; heme regulated initiation factor 2 alpha kinase; heme-regulated initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2-alpha kinase; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase;
Cat.#:EIF2AK1-3146HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2AK1 Protein, GST-tagged
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Cat.#:EIF2AK1-703HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EIF2AK1, GST-His
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Cat.#:EIF2AK1-12349HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF2AK1, GST-tagged
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Cat.#:EIF2AK1-5075MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF2AK1 Protein
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Cat.#:EIF2AK1-2043RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF2AK1 Protein
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Cat.#:EIF2AK1-484CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EIF2AK1 Protein, His-tagged
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Cat.#:EIF2AK1-6216CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF2AK1
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Cat.#:EIF2AK1-4777ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2AK1
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Cat.#:EIF2AK1-538HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF2AK1 cell lysate
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Involved Pathway

EIF2AK1 involved in several pathways and played different roles in them. We selected most pathways EIF2AK1 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
DNAJC5; DNAJA1; CAPN2A; HSPA4L; DNAJB1A; UBE2E3; ERP29; CCDC102A; DNAJB2; HSP26
Hepatitis C
CLDN18; CLDN15; MAPK3; NFKB1; CLDN6; Ifna15; STAT3; TRAF6; RXRA; CLDN16
Measles
RELA; IL6; IFNB1; TLR7; AKT2; OAS1B; TLR4; RAB9A; PIK3CA; IL1A
Influenza A
IFNA17; STAT1; IFNA6; BLB2; MYD88; HSPA6; MAPK11; HLA-DOB; FURIN; HSPA2
Herpes simplex infection
TBPL1; ARNTL1A; C3; TBP; FAS; SOCS3; JAK2B; CDC34A; PPP1CAB; NFKBIA
Epstein-Barr virus infection
POLR3B; PIK3R3; HLA-DQA2; MAPK9; TYK2; NCOR2; HLA-B; PRKACA; HDAC5; PLCG1

Protein Function

EIF2AK1 has several biochemical functions, for example, ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK1 itself. We selected most functions EIF2AK1 had, and list some proteins which have the same functions with EIF2AK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NAGK; ABCA4A; RPS6KB1B; PTK2; GSG2; ENTPD2; TSSK2; KIF5B; CDK14; ATP5B
Function eukaryotic translation initiation factor 2alpha kinase activity
Related Protein ALPK2; EIF2AK2; EIF2AK4; EIF2AK3; EIF2AK1
Function heme binding
Related Protein CYP2J5; CYP2C9; CYP11B1; CYP46A1.3; PTGESL; CYP2AA12; NOS1; CYP4T8; CYP4Z1; CYP2C38
Function protein homodimerization activity
Related Protein COMMD1; CALCOCO2; ZFP652; B4GALT1; ZNF174; GRPEL2; UGT1A6B; STC2; NR6A1B; XCL1

Interacting Protein

EIF2AK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK1.
HSP90AB1; nhaA; btuC; linkable pd173955 analogue; bosutinib; imatinib; CDC37

EIF2AK1 Related Articles

Skalnikova, H; Vodicka, P; et al. Protein signaling pathways in differentiation of neural stem cells. PROTEOMICS 8:4547-4559(2008).
Cui, J; Han, SY; et al. c-Jun NH2-terminal kinase 2 alpha 2 promotes the tumorigenicity of human glioblastoma cells. CANCER RESEARCH 66:10024-10031(2006).