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EIF2AK1

  • Official Full Name

    eukaryotic translation initiation factor 2-alpha kinase 1

  • Overview

    The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Synonyms

    EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; HRI; heme-regulated inhibitor; heme-regulated repressor; heme-controlled repressor; heme sensitive initiation factor 2a kinase; heme regulated initiation factor 2 alpha kinase; heme-regulated initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2-alpha kinase; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2AK1-703H Recombinant Human EIF2AK1, GST-His Sf9 Insect Cell GST
Human EIF2AK1-12349H Recombinant Human EIF2AK1 protein, His-tagged E.coli His 281-630 aa
Human EIF2AK1-3146H Recombinant Human EIF2AK1 Protein, GST-tagged Wheat Germ GST
Human EIF2AK1-538HCL Recombinant Human EIF2AK1 cell lysate N/A
Human EIF2AK1-6862HF Active Recombinant Full Length Human EIF2AK1 Protein, GST-tagged E.coli GST 1-630(end)
Human EIF2AK1-1412H Recombinant Human EIF2AK1 Protein, His-tagged E.coli N-His Phe167-Phe583
Human EIF2AK1-0679H Recombinant Human EIF2AK1 Protein (S161-S586), Tag Free E.coli No tag S161-S586
Human EIF2AK1-4487HF Recombinant Full Length Human EIF2AK1 Protein, GST-tagged In Vitro Cell Free System GST 630 amino acids
Human EIF2AK1-0680H Recombinant Human EIF2AK1 Protein (S161-S586), His/GST tagged E.coli His/GST S161-S586
Mouse EIF2AK1-5075M Recombinant Mouse EIF2AK1 Protein Mammalian Cell His
Mouse EIF2AK1-2698M Recombinant Mouse EIF2AK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EIF2AK1-2698M-B Recombinant Mouse EIF2AK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Eif2ak1-1411M Recombinant Mouse Eif2ak1 Protein, His-tagged E.coli N-His Phe167-Phe580
Rat EIF2AK1-2043R Recombinant Rat EIF2AK1 Protein Mammalian Cell His
Rat EIF2AK1-1700R Recombinant Rat EIF2AK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF2AK1-1700R-B Recombinant Rat EIF2AK1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey EIF2AK1-484C Recombinant Cynomolgus EIF2AK1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey EIF2AK1-229C-B Recombinant Cynomolgus Monkey EIF2AK1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey EIF2AK1-229C Recombinant Cynomolgus Monkey EIF2AK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish EIF2AK1-4777Z Recombinant Zebrafish EIF2AK1 Mammalian Cell His
Chicken EIF2AK1-6216C Recombinant Chicken EIF2AK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF2AK1 Related Articles

EIF2AK1 involved in several pathways and played different roles in them. We selected most pathways EIF2AK1 participated on our site, such as Protein processing in endoplasmic reticulum, Hepatitis C, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumRRBP1B;DNAJC5B;UBQLN1;CALRL2;NFE2L2A;SSR2;MAPK10;HNF4B;MAP2K7
Hepatitis COAS2;PPP2R1A;CLDN22;TP53;CLDN2;IFNA7;IKBKG;STAT2;IFNA8
MeaslesCd209g;TAB2;CCNE2;HSPA8;Ifna11;TLR2;DOK1;IFNA6;IFNA5
Influenza ATNFRSF10A;NLRX1;FAS;HSPA1B;CXCL10;HLA-DPA1;PIK3CA;PABPN1;RSAD2
Herpes simplex infectionSFRS9;SRSF1;HLA-DOB;FASLG;SRSF5;Hc;NFKBIA;TNFRSF14;PPP1CAA
Epstein-Barr virus infectionMAP2K4;MAP3K14;PSMD2;MAPK13;HLA-DRB3;EIF2AK1;PIK3CG;ENTPD8;PSMD11

EIF2AK1 has several biochemical functions, for example, ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK1 itself. We selected most functions EIF2AK1 had, and list some proteins which have the same functions with EIF2AK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingERBB3A;FYN;ETNK2;NEK5;ATP6V1B2;KIF22;PAK2A;TPX2;LRRK2
eukaryotic translation initiation factor 2alpha kinase activityEIF2AK3;EIF2AK4;EIF2AK2;ALPK2;EIF2AK1
heme bindingCYP2C70;GUCY1B3;CYP1D1;CYP17A2;CYP2AA3;CYP2E1;HBM;HBA-A2;TDO2
protein homodimerization activityIMPA2;PEX7;TREX2;DPY30;BCL2L10;ADH5;NTRK2;QPRT;GOT2

EIF2AK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK1.

HSP90AB1; nhaA; btuC; linkable pd173955 analogue; bosutinib; imatinib; CDC37

Skalnikova, H; Vodicka, P; et al. Protein signaling pathways in differentiation of neural stem cells. PROTEOMICS 8:4547-4559(2008).
Cui, J; Han, SY; et al. c-Jun NH2-terminal kinase 2 alpha 2 promotes the tumorigenicity of human glioblastoma cells. CANCER RESEARCH 66:10024-10031(2006).
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