eif2s2
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  • Official Full Name
  • eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
  • Background
  • Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.
  • Synonyms
  • EIF2S2; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; EIF2, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic translation initiation factor 2 subunit 2; EIF2beta; PPP1R67; protein phosphatase 1; regulato
Cat.#:EIF2S2-3173HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2S2 Protein, GST-tagged
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Cat.#:EIF2S2-354HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EIF2S2 Protein, MYC/DDK-tagged
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Cat.#:EIF2S2-1420RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EIF2S2 Protein, His-tagged
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Cat.#:EIF2S2-6166CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF2S2
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Cat.#:EIF2S2-11951ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2S2
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Cat.#:EIF2S2-6665HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF2S2 293 Cell Lysate
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Involved Pathway

EIF2S2 involved in several pathways and played different roles in them. We selected most pathways EIF2S2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
CYFIP2; SIP1; SMN; PABPC3; EIF4EBP3L; GEMIN7; GEMIN2; TGS1; EEF1A2; NUP210L

Protein Function

EIF2S2 has several biochemical functions, for example, RNA binding, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S2 itself. We selected most functions EIF2S2 had, and list some proteins which have the same functions with EIF2S2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein SMN2; RBMS1; APOBEC2; CPSF5; METTL3; BARHL1; PAPOLB; RPS3A; AGO3B; ADAT1
Function metal ion binding
Related Protein ZNF436; CAR6; ZCCHC18; ZFP553; WT1B; ZNRF3; PPM1LB; ZNF397; ERI3; CBFA2T2
Function poly(A) RNA binding
Related Protein IGF2BP2; PSIP1; RBM47; SART1; MEX3C; RPL7; DHX34; NUCKS1; PPIG; RPS14
Function protein binding
Related Protein GLDN; PIM1; SFTPD; WBP1; PCBD2; CRNKL1; MED31; PKP1; BID; TCP1
Function translation factor activity, RNA binding
Related Protein EIF4A1; EIF2S3; EIF4G3; GTF2H3; MTIF3; SOX11; EEF1A2; ABCF1; CPEB4; CPEB2
Function translation initiation factor activity
Related Protein EIF2S3; EIF3JA; EIF3F; EIF2S3Y; EIF2D; EIF2S2; EIF4E2; EIF3S6IP; MTIF2; EIF2S1B

Interacting Protein

EIF2S2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S2.
EIF2S1; EIF4G2; EIF2S3; CSNK2A1; EIF2B2; oks16_human; TP53; APLP1; TLE1; ZBTB16

EIF2S2 Related Articles

Gatza, ML; Silva, GO; et al. An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer. NATURE GENETICS 46:1051-1059(2014).
Heaney, JD; Michelson, MV; et al. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. HUMAN MOLECULAR GENETICS 18:1395-1404(2009).