eif2s3
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  • Official Full Name
  • eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
  • Background
  • The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
  • Synonyms
  • EIF2S3; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; EIF2; EIF2G; eIF-2gA; EIF2gamma; eukaryotic translation initiation factor 2 subunit 3; eIF-2gX; eIF-2-gamma X; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2 subunit gamma X;
Cat.#:EIF2S3-3175HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF2S3 Protein, GST-tagged
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Cat.#:EIF2S3-28379THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EIF2S3
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Cat.#:EIF2S3-1407CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF2S3
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Cat.#:EIF2S3-11986ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF2S3
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Involved Pathway

EIF2S3 involved in several pathways and played different roles in them. We selected most pathways EIF2S3 participated on our site, such as ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ABC-family proteins mediated transport
ABCA7; APOA1B; CFTR; KCNJ11; ABCB8; EIF2S1A; ABCC2; EIF2S3; EIF2S1; ABCC9
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
FAUB; EIF4A2; EIF3K; EIF4H; EIF4EB; EIF2S3; EIF2S1; EIF1AXA; EIF4A1; EIF4G1
Cap-dependent Translation Initiation
EIF2B1; RPL35; EIF2S3; EIF2S1; EIF1AXA; EIF4A2; EIF4H; EIF4G1; EIF4E; EIF1AX
Eukaryotic Translation Initiation
EIF1AXA; EIF2B1; RPL35; EIF4A2; EIF4H; EIF4A1; EIF4B; EIF5; EIF4G1; EIF4EB
Formation of the ternary complex, and subsequently, the 43S complex
EIF3K; EIF1AX; EIF2S1A; EIF1AXA; FAUB; EIF2S3; EIF2S1
GTP hydrolysis and joining of the 60S ribosomal subunit
EIF5; FAUB; EIF2S1; RPL35; EIF4A1; EIF1AXA; EIF4H; EIF2S1A; EIF2S3; EIF3K
Gene Expression
HNRPL; ZFP37; ZNF480; PLD6; POLR3H; TSEN54; MBD3; RPP14; ZNF70; ZNF692
L13a-mediated translational silencing of Ceruloplasmin expression
FAUB; EIF2S1A; EIF3K; EIF4H; EIF2S3; EIF1AX; EIF1AXA

Protein Function

EIF2S3 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S3 itself. We selected most functions EIF2S3 had, and list some proteins which have the same functions with EIF2S3. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RAP2B; RASL10A; ARFIP2; ARF1; RAB32; GNA11A; RAB3AB; RAB33A; RHOV; DNM2B
Function GTPase activity
Related Protein RAB2A; EIF5B; RAB3DA; ARL2; RAB18B; DNM1; GNA12A; ARL8B; RAB40B; RHOJ
Function protein binding
Related Protein PYGO1; ACAP1; POLR1B; GGA3; HINT2; H3F3C; C15orf23; P4HA2; SRSF3; C1QTNF1
Function translation factor activity, RNA binding
Related Protein CPEB4; ABCF1; CPEB1; EIF4G2; EIF1AX; EIF4A1; CPEB3; CPEB1B; SOX11; GTF2H3
Function translation initiation factor activity
Related Protein EIF4G2; EIF4E1B; EIF2S2; EIF3S10; EIF2B5; EIF1AD; EIF2D; EIF1AXA; EIF1AX; EIF3B

Interacting Protein

EIF2S3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S3.
EIF2S1; EIF2S2; EIF1B; GH1; HLA-B; CASP4; IKBKE; NDRG1; PRKAB1; TRAF6; yopM; ychF; ssrna_ug

EIF2S3 Related Articles

Chang, YT; Yao, CT; et al. Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets. WORLD JOURNAL OF GASTROENTEROLOGY 20:17476-17482(2014).
Chang, YT; Huang, CS; et al. Gene expression profile of peripheral blood in colorectal cancer. WORLD JOURNAL OF GASTROENTEROLOGY 20:14463-14471(2014).