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EIF4A2

  • Official Full Name

    eukaryotic translation initiation factor 4A2

  • Overview

    Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM).
  • Synonyms

    EIF4A2; eukaryotic translation initiation factor 4A2; DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II; eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase eIF4A-2; eukaryotic translation initiation factor 4A, isoform 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF4A2-12376H Recombinant Human EIF4A2, GST-tagged E.coli GST C-term-300a.a.
Human EIF4A2-47H Recombinant Human EIF4A2 protein, His-tagged E.coli His 422aa(including fusion tag)
Human EIF4A2-3195H Recombinant Human EIF4A2 Protein, GST-tagged Wheat Germ GST
Human EIF4A2-6653HCL Recombinant Human EIF4A2 293 Cell Lysate HEK293 N/A
Human EIF4A2-3917H Recombinant Human EIF4A2 protein, His-tagged E.coli His 1-408 aa
Human EIF4A2-826H-B Recombinant Human EIF4A2 Protein Pre-coupled Magnetic Beads HEK293
Human EIF4A2-4364H Recombinant Human EIF4A2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF4A2-4284HF Recombinant Full Length Human EIF4A2 Protein, GST-tagged In Vitro Cell Free System GST 407 amino acids
Human EIF4A2-826H Recombinant Human EIF4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EIF4A2-4383H Recombinant Human EIF4A2 protein, GST-tagged E.coli GST 1-407aa
Human EIF4A2-956HFL Recombinant Full Length Human EIF4A2 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Eif4a2-2785M Recombinant Mouse Eif4a2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat EIF4A2-2064R Recombinant Rat EIF4A2 Protein Mammalian Cell His
Rat EIF4A2-1721R Recombinant Rat EIF4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF4A2-1721R-B Recombinant Rat EIF4A2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey EIF4A2-488C Recombinant Cynomolgus EIF4A2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey EIF4A2-233C Recombinant Cynomolgus Monkey EIF4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey EIF4A2-233C-B Recombinant Cynomolgus Monkey EIF4A2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EIF4A2-1426R Recombinant Rhesus monkey EIF4A2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EIF4A2-1250R-B Recombinant Rhesus Macaque EIF4A2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EIF4A2-1250R Recombinant Rhesus Macaque EIF4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish EIF4A2-12621Z Recombinant Zebrafish EIF4A2 Mammalian Cell His
Chicken EIF4A2-6118C Recombinant Chicken EIF4A2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF4A2 Related Articles
  • EIF4A2 Related Signal Pathway

EIF4A2 involved in several pathways and played different roles in them. We selected most pathways EIF4A2 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SEIF1AXA;EIF4G1;EIF4EBP1;EIF3K;EIF4H;FAUB;EIF1AX;EIF4E;EIF4B
Antiviral mechanism by IFN-stimulated genesEIF4E;ARIH1L;KPNA3;IFIT8;EIF4G1;NUP35;EIF4A2;NUP50;NUPL2
Cap-dependent Translation InitiationEIF4E;EIF4B;EIF3K;RPL35;EIF4G1;EIF4A1;EIF4H;EIF2S1;FAUB
Cytokine Signaling in Immune systemGBP1;FCGR1B;PEA15;PEA15A;TAB1;IFITM3;UBE2V1;CSHL1;SPTB
Deadenylation of mRNAEIF4EB;D1BWG0212E;EIF4B;EIF4G1;PAIP1;EIF4A2;EIF4A1;C2orf29;EIF4E
Deadenylation-dependent mRNA decayEIF4A1;PAIP1;EIF4B;EIF4E;NT5C3B;TNKS1BP1;C2orf29;EIF4G1;D1BWG0212E
Eukaryotic Translation InitiationEIF4B;EIF2S1;EIF2S3;FAUB;EIF4EB;EIF2B1;RPL35;EIF4A1;EIF3K
GTP hydrolysis and joining of the 60S ribosomal subunitEIF1AXA;EIF2S1;EIF5;EIF1AX;EIF2S1A;EIF4H;FAUB;EIF4A1;RPL35

EIF4A2 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A2 itself. We selected most functions EIF4A2 had, and list some proteins which have the same functions with EIF4A2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIKBKAP;OXSR1;STK30;MAP4K2;KIF3CB;EGFR;UBE2U;CHD9;PANK1A
ATP-dependent RNA helicase activityDHX38;EIF4A2;DDX47;DDX19;DHX57;DDX39A;BAT1;DDX25;CHST13
ATPase activityHLTF;KIF7;CARNS1;SMARCA4A;PSMC1;ABCB3L1;DNAHC8;DNAH6;PMS2
helicase activityDHX34;DDX6;SHPRH;DDX58;DDX52;DQX1;RTEL1;UPF1;PL10
poly(A) RNA bindingPABPC4;MRPL41;STRBP;RPL6;SRSF7;DDX17;ANKRD17;ZFP36L1;NVL
protein bindingGABPB1;KPNA5;FAM96A;MID1IP1;FAM207A;PPP1R2P9;ANG;CENPL;ACTG1
translation initiation factor activityEIF1;GTPBP1;EIF4E3;EIF4E1C;EIF5;EIF4B;EIF5B;EIF3E;EIF2B5

EIF4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A2.

PDCD4; p27958-pro_0000037577; EIF4G1; EIF3H; EIF4G2; DPPA4

Yan, X; Dong, XC; et al. Reference Gene Selection for Quantitative Real-Time PCR Normalization in Reaumuria soongorica. PLOS ONE 9:-(2014).
Lu, WT; Wilczynska, A; et al. The diverse roles of the eIF4A family: you are the company you keep. BIOCHEMICAL SOCIETY TRANSACTIONS 42:166-172(2014).
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