EIF4A2 Protein, eukaryotic translation initiation factor 4A2

EIF4A2

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EIF4A2

Official Full Name eukaryotic translation initiation factor 4A2
Background Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM).
Synonyms EIF4A2; eukaryotic translation initiation factor 4A2; DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II; eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase eIF4A-2; eukaryotic translation initiation factor 4A, isoform 2;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4A2-12376H Recombinant Human EIF4A2, GST-tagged E.coli GST
    Human EIF4A2-3195H Recombinant Human EIF4A2 Protein, GST-tagged Wheat Germ GST
    Human EIF4A2-47H Recombinant Human EIF4A2 protein, His-tagged E.coli His
    Human EIF4A2-6653HCL Recombinant Human EIF4A2 293 Cell Lysate HEK293 N/A
    Rat EIF4A2-2064R Recombinant Rat EIF4A2 Protein Mammalian Cell His
    Cynomolgus Monkey EIF4A2-488C Recombinant Cynomolgus EIF4A2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque EIF4A2-1426R Recombinant Rhesus monkey EIF4A2 Protein, His-tagged Mammalian Cell His
    Chicken EIF4A2-6118C Recombinant Chicken EIF4A2 Mammalian Cell His
    Zebrafish EIF4A2-12621Z Recombinant Zebrafish EIF4A2 Mammalian Cell His

    EIF4A2 involved in several pathways and played different roles in them. We selected most pathways EIF4A2 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF4B; EIF3K; EIF1AXA; EIF2S1A; EIF4EBP1; EIF4A2; EIF4E; FAUB; EIF1AX; EIF2S1
    Antiviral mechanism by IFN-stimulated genes NUP35; NUP50; KPNA4; UBE2L6; IFIT12; NUPL2; EIF4G1; IFIT8; EIF4G2; IFIT14
    Cap-dependent Translation Initiation EIF1AXA; FAUB; EIF4EBP1; EIF4H; EIF1AX; EIF4G1; EIF4A2; EIF4B; EIF4A1; EIF4E
    Cytokine Signaling in Immune system GBP1; IFIT10; TRIM29; TRIM26; IFIT8; RASGEF1A; PEBP1; GBP5; EDAR; SPTBN1
    Deadenylation of mRNA EIF4G1; C2orf29; EIF4B; TNKS1BP1; EIF4A2; EIF4E; PAIP1; EIF4A1; EIF4EB; D1BWG0212E
    Deadenylation-dependent mRNA decay LSM6; NT5C3B; EIF4G1; DCP1B; PAIP1; EIF4A1; EIF4EB; C2orf29; DCP2; TNKS1BP1
    Eukaryotic Translation Initiation FAUB; EIF1AXA; EIF4A2; EIF4B; EIF4G1; RPL35; EIF2B1; EIF2S1A; EIF1AX; EIF4H
    GTP hydrolysis and joining of the 60S ribosomal subunit FAUB; EIF2S1A; EIF2S3; EIF4H; EIF4B; EIF1AX; EIF4A2; EIF1AXA; EIF5; EIF2S1

    EIF4A2 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A2 itself. We selected most functions EIF4A2 had, and list some proteins which have the same functions with EIF4A2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DCAKD; MAP2K7; ATP6V1BA; TARS; CAMKVB; MAP2K5; PRKG1A; UBA1; ATAD1; CSNK2A2
    ATP-dependent RNA helicase activity DDX21; EIF4A2; DHX36; DDX39; DDX3; DDX23; DDX5; DHX35; DDX3Y; TDRD9
    ATPase activity KIF7; DNA2; TOR1A; KIF13B; ABCA1B; ABCC8; ABCE1; PMS2; EIF4A2; ATAD2
    helicase activity SMARCA5; EIF4A1A; SNRNP200; DDX19; CHD6; PIF1; MOV10; SUPV3L1; DHX32A; ANXA1
    poly(A) RNA binding PCBP4; ELAVL2; DHX38; U2SURP; ZMAT3; HSP90AA1; NPM3; ZFP326; FUS; RRP9
    protein binding RAP2A; CD46; CD79B; CRYBA1; LHFPL5; RAD51D; FFAR2; TLX1; RBCK1; CDC37L1
    translation initiation factor activity EIF1AD; GTPBP1L; EIF2A; EIF2S1; EIF3JA; EIF1AY; COPS5; EIF1; EIF3F; DHX29

    EIF4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A2.

    PDCD4; p27958-pro_0000037577; EIF4G1; EIF3H; EIF4G2; DPPA4

    Yan, X; Dong, XC; et al. Reference Gene Selection for Quantitative Real-Time PCR Normalization in Reaumuria soongorica. PLOS ONE 9:-(2014).
    Lu, WT; Wilczynska, A; et al. The diverse roles of the eIF4A family: you are the company you keep. BIOCHEMICAL SOCIETY TRANSACTIONS 42:166-172(2014).

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