eif4ebp1
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  • Official Full Name
  • EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
  • Background
  • Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene. This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
  • Synonyms
  • EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heat and acid stable protein regulated by insulin 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316
Cat.#:EIF4EBP1-3203HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF4EBP1 Protein, GST-tagged
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Cat.#:EIF4EBP1-1397HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4EBP1
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Cat.#:EIF4EBP1-154HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4EBP1 protein, His-tagged
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Cat.#:EIF4EBP1-1845HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4EBP1 protein, His-tagged
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Cat.#:EIF4EBP1-26388THTag:His
Source (Host):Species:Human
Product nameRecombinant Human EIF4EBP1, His-tagged
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Cat.#:EIF4EBP1-28496THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4EBP1
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Cat.#:EIF4EBP1-3804HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4EBP1, His tagged
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Cat.#:Eif4ebp1-1846MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Eif4ebp1 protein, His-tagged
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Cat.#:EIF4EBP1-5110MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF4EBP1 Protein
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Cat.#:Eif4ebp1-1847RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Eif4ebp1 protein, His-tagged
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Cat.#:EIF4EBP1-2067RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF4EBP1 Protein
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Cat.#:EIF4EBP1-10046ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF4EBP1
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Cat.#:EIF4EBP1-6649HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EIF4EBP1 293 Cell Lysate
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Involved Pathway

EIF4EBP1 involved in several pathways and played different roles in them. We selected most pathways EIF4EBP1 participated on our site, such as AMPK signaling, AMPK signaling pathway, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4EBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMPK signaling
EIF4EBP1; CPT1A; CPT1B; CPT1C; CDKN1A; INS-IGF2; ADRA1B; ADRa1A; ELAVL1; EEF2
AMPK signaling pathway
CREB3L4; CRTC2; RPS6KB2; PRKAG2; EIF4EBP1; CCNA2; AKT3; CAB39; EEF2; LEPR
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
EIF4A2; EIF1AXA; FAUB; EIF2S3; EIF4H; EIF4EBP1; EIF2S1A; EIF1AX; EIF4B; EIF4G1
Acute myeloid leukemia
RARA; CHUK; PIK3R5; BAD; KIT; ZBTB16; RPS6KB1; AKT2; RELA; SPI1
Alpha6-Beta4 Integrin Signaling Pathway
DSP; NTN1A; CD151L; COL17A1; EIF4EBP1; PLEC; DST; YWHAQ; CLCA1; MST1R
BDNF signaling pathway
EGR1; SYN1; GNB2L1; CSNK2A1P; SIRPA; BCL2L11; CDKL5; DOK5; CDK5; LINGO1
Cap-dependent Translation Initiation
EIF4B; EIF4A1; EIF1AXA; EIF5; RPL35; EIF2S1; EIF4G1; EIF4EBP1; EIF2S1A; EIF2S3
Choline metabolism in cancer
PIK3CD; RPS6KB2; TAE1; HRAS; RAF1; PDGFRA; CHKA; EIF4EBP1; PCYT1A; PIK3CA

Protein Function

EIF4EBP1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding, protein binding, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4EBP1 itself. We selected most functions EIF4EBP1 had, and list some proteins which have the same functions with EIF4EBP1. You can find most of the proteins on our site.
Function
Related Protein
Function eukaryotic initiation factor 4E binding
Related Protein LARP1; EIF4EBP2; EIF4EBP1; HHEX; EIF4EBP3L; DDX3X; EIF4EBP3; OTX2; GRA; ANGEL1
Function protein binding
Related Protein APAF1; NUP62; MS4A3; AURKAIP1; MAPK6; TSC1; CUL4B; CCDC94; TFAP2A; TMEM149
Function protein phosphatase 2A binding
Related Protein MASTL; STRN; ANKLE2; MAPT; PPP2R2A; SHC1; PTPN1; AKT1; SPHK1; BCL2
Function translation repressor activity
Related Protein PATL2; EIF4EBP2; IREB2; TRIM71; SAMD4; PAIP2; EIF4EBP1; SAMD4A; EIF4EBP3; CIRBP

Interacting Protein

EIF4EBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4EBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4EBP1.
EIF4E; RPTOR; TCF4

EIF4EBP1 Related Articles

Wang, ZS; Ma, XH; et al. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 94:1243-1253(2012).
Bidinosti, M; Martineau, Y; et al. Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain. JOURNAL OF BIOLOGICAL CHEMISTRY 285:19402-19408(2010).