ELAC2
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Official Full Name
elaC homolog 2 (E. coli) -
Overview
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ELAC2;elaC homolog 2 (E. coli);elaC (E. coli) homolog 2;zinc phosphodiesterase ELAC protein 2;FLJ10530;HPC2;tRNase Z (long form);ElaC homolog protein 2;ELC2;FLJ36693;FLJ42848;Heredity prostate cancer protein 2;putative prostate cancer susceptibility protein HPC2/ELAC2;Ribonuclease Z 2;Ribonuclease Z2;RNase Z 2;RNase Z2;RNZ2_HUMAN;tRNA 3 endonuclease 2;tRNase Z 2;tRNase Z2
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ELAC2-12395H | Recombinant Human ELAC2, GST-tagged | E.coli | Human | GST | 86-385a.a. | |
| ELAC2-2073R | Recombinant Rat ELAC2 Protein | Mammalian Cells | Rat | His |
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| ELAC2-3229H | Recombinant Human ELAC2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ELAC2-8126Z | Recombinant Zebrafish ELAC2 | Mammalian Cells | Zebrafish | His |
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| ELAC2-6638HCL | Recombinant Human ELAC2 293 Cell Lysate | HEK293 | Human | Non |
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| ELAC2-1730R | Recombinant Rat ELAC2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| ELAC2-1730R-B | Recombinant Rat ELAC2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Elac2-2796M | Recombinant Mouse Elac2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| ELAC2-4335HF | Recombinant Full Length Human ELAC2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 826 amino acids |
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| ELAC2-6299H | Recombinant Human ELAC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
ELAC2 involved in several pathways and played different roles in them. We selected most pathways ELAC2 participated on our site, such as Gene Expression,RNA transport,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF4G2B,NUP210,RANGAP1A,EIF3I,SENP2,CYFIP1,EIF4EA,EIF1,EIF2B2,RPP25 |
| Gene Expression | MED13A,DARS,TAF1B,ADAT3,TTC6,RRAGA,APEH,NR6A1A,USP9X,SAP130 |
| tRNA processing in the nucleus | C14orf166,FAM98B,ZBTB8OS,RPP40,C2orf49,POP4,RPP38,TSEN34,RPP14,POP7 |
| tRNA processing | C2orf49,TRMT1,LBH,TYW5,RPP38,ADAT1,LAGE3,TPRKB,ADAT2,TP53RK |
Protein Function
ELAC2 has several biochemical functions, for example, 3-tRNA processing endoribonuclease activity,metal ion binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAC2 itself. We selected most functions ELAC2 had, and list some proteins which have the same functions with ELAC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-tRNA processing endoribonuclease activity | ELAC1 |
| poly(A) RNA binding | ZNF326,SF3B14,QKI,PABPC4,LUC7L3,TPT1,RPL37A,DDX31,SNRNP40,SRP19 |
| metal ion binding | CHPF,TRIM35-39,TPH1B,TRIM55A,PPP1CB,DMRT2,RRM2B,CELA1,NGB,BMX |
Interacting Protein
ELAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAC2.
PUF60;NDUFA7;CUX1;GOLM1;ASCC2;q9wmx2-pro_0000037549;Rpl35;CAMKK1;Bag2
Resources
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References
- Cartwright, R; Mangera, A; et al. Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men. EUROPEAN UROLOGY 66:752-768(2014).
- Zhou, H; Zhou, M; et al. RNase Z(S1) processes Ub(L40) mRNAs and controls thermosensitive genic male sterility in rice. NATURE COMMUNICATIONS 5:-(2014).
