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Official Full Name elaC homolog 2 (E. coli)
Background The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); ElaC homolog protein 2; ELC2; FLJ36693; FLJ42848; Heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; Ribonuclease Z2; RNase Z 2; RNase Z2; RNZ2_HUMAN; tRNA 3 endonuclease 2; tRNase Z 2; tRNase Z2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Elac2-2796M Recombinant Mouse Elac2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ELAC2-6299H Recombinant Human ELAC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ELAC2-12395H Recombinant Human ELAC2, GST-tagged E.coli GST
    Human ELAC2-3229H Recombinant Human ELAC2 Protein, GST-tagged Wheat Germ GST
    Human ELAC2-6638HCL Recombinant Human ELAC2 293 Cell Lysate HEK293 N/A
    Rat ELAC2-2073R Recombinant Rat ELAC2 Protein Mammalian Cell His
    Zebrafish ELAC2-8126Z Recombinant Zebrafish ELAC2 Mammalian Cell His

    ELAC2 involved in several pathways and played different roles in them. We selected most pathways ELAC2 participated on our site, such as Gene Expression, RNA transport, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression LSM11; NR1I2; YBX1; TAF1D; BRF2; SF3A1; ZNF436; ZNF180; MED6; ZNF354B
    tRNA processing METTL1; C14orf166; TRMT11; C2orf49; TYW5; TSEN15; TPRKB; ELAC2; ZBTB8OS; PUS7
    tRNA processing in the nucleus POP4; RPP30; C22orf28; ELAC2; FAM98B; C14orf166; XPOT; RPP14; TSEN2; C2orf49

    ELAC2 has several biochemical functions, for example, 3-tRNA processing endoribonuclease activity, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELAC2 itself. We selected most functions ELAC2 had, and list some proteins which have the same functions with ELAC2. You can find most of the proteins on our site.

    Function Related Protein
    3-tRNA processing endoribonuclease activity ELAC1; ELAC2
    metal ion binding FOXP2; FAHD2A; NEK11; Amy1; KLF7B; BCL11B; ZEB2; ZBTB12.1; CARS; PVALB3
    poly(A) RNA binding RBM42; SCAF4; CIRBP; MRPL11; XRN2; HTATSF1; ADAR; PCBP4; PABPC4; PSIP1

    ELAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELAC2.

    PUF60; NDUFA7; CUX1; GOLM1; ASCC2; q9wmx2-pro_0000037549; Rpl35; CAMKK1; Bag2

    Cartwright, R; Mangera, A; et al. Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men. EUROPEAN UROLOGY 66:752-768(2014).
    Zhou, H; Zhou, M; et al. RNase Z(S1) processes Ub(L40) mRNAs and controls thermosensitive genic male sterility in rice. NATURE COMMUNICATIONS 5:-(2014).

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