Recombinant Human ELAC2 Protein, GST-tagged

• Cat.No.: ELAC2-3229H
• Product Overview: Human ELAC2 full-length ORF ( NP_060597.3, 1 a.a. - 826 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 118.6 kDa
• AA Sequence: MWALCSLLRSAAGRTMSQGRTISQA PARRERPRKDPLRHLRTREKRGPSG CSGGPNTVYLQVVAAGSRDSGAALY VFSEFNRYLFNCGEGVQRLMQEHKL KVARLDNIFLTRMHWSNVGGLSGMI LTLKETGLPKCVLSGPPQLEKYLEA IKIFSGPLKGIELAVRPHSAPEYED ETMTVYQIPIHSEQRRGKHQPWQSP ERPLSRLSPERSSDSELNENEPHLP HGVSQRRGVRDSSLVVAFICKLHLK RGNFLVLKAKEMGLPVGTAAIAPII AAVKDGKSITHEGREILAEELCTPP DPGAAFVVVECPDESFIQPICENAT FQRYQGKADAPVALVVHMAPASVLV DSRYQQWMERFGPDTQHLVLNENCA SVHNLRSHKIQTQLNLIHPDIFPLL TSFRCKKEGPTLSVPMVQGECLLKY QLRPRREWQRDAIITCNPEEFIVEA LQLPNFQQSVQEYRRSAQDGPAPAE KRSQYPEIIFLGTGSAIPMKIRNVS ATLVNISPDTSLLLDCGEGTFGQLC RHYGDQVDRVLGTLAAVFVSHLHAD HHTGLPSILLQRERALASLGKPLHP LLVVAPNQLKAWLQQYHNQCQEVLH HISMIPAKCLQEGAEISSPAVERLI SSLLRTCDLEEFQTCLVRHCKHAFG CALVHTSGWKVVYSGDTMPCEALVR MGKDATLLIHEATLEDGLEEEAVEK THSTTSQAISVGMRMNAEFIMLNHF SQRYAKVPLFSPNFSEKVGVAFDHM KVCFGDFPTMPKLIPPLKALFAGDI EEMEERREKRELRQVRAALLSRELA GGLEDGEPQQKRAHTEEPQAKKVRA Q
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ELAC2 elaC homolog 2 (E. coli) [ Homo sapiens ]
• Official Symbol: ELAC2
• Synonyms: ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); RNase Z 2; tRNase Z 2; ribonuclease Z 2; tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; ELC2; FLJ36693; FLJ42848
• Gene ID: 60528
• mRNA Refseq: NM_001165962
• Protein Refseq: NP_001159434
• MIM: 605367
• UniProt ID: Q9BQ52