ephb3
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  • Official Full Name
  • EPH receptor B3
  • Background
  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members.
  • Synonyms
  • EPHB3; EPH receptor B3; EphB3 , ETK2; ephrin type-B receptor 3; Hek2; Tyro6; EK2; EPH-like kinase 2; embryonic kinase 2; human embryo kinase 2; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; tyrosine-protein kinase TYRO6; ETK2
Cat.#:EPHB3-1900HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB3 Protein, MYC/DDK-tagged
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Cat.#:EPHB3-3401HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPHB3 Protein, GST-tagged
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Cat.#:EPHB3-305HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor B3, GST-tagged, Active
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Cat.#:Ephb3-1728MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Eph Receptor B3
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Cat.#:EPHB3-28578THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EPHB3
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Cat.#:EPHB3-376HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHB3 Protein, DDK/His-tagged
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Cat.#:EPHB3-377HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHB3 Protein, DDK-tagged
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Cat.#:EPHB3-563HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EPHB3
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Cat.#:EPHB3-8627HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHB3, His & GST tagged
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Cat.#:Ephb3-1135MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ephb3 protein, His & T7-tagged
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Cat.#:Ephb3-4051MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ephb3, His tagged
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Cat.#:Ephb3-1160RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ephb3 Protein, His-tagged
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Cat.#:EPHB3-1214HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPH Receptor B3, GST-tagged
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Cat.#:EPHB3-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHB3 cell lysate
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Cat.#:EPHB3-2131MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EPHB3 cell lysate
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Cat.#:Kit-1555Tag:N/A
Source (Host):Species:
Product nameU2OS EphB3 Bioassay Kit
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Cat.#:Kit-1584Tag:N/A
Source (Host):Species:
Product nameEphB3 Functional Assay Kit
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Involved Pathway

Ephb3 involved in several pathways and played different roles in them. We selected most pathways Ephb3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ephb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
CSF2RB; CSNK2A1; EFNA1A; EPHA2A; EPHA1; RAC2; ABLIM3; CLTB; RHOGA; SEMA3E

Protein Function

Ephb3 has several biochemical functions, for example, ATP binding, axon guidance receptor activity, ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ephb3 itself. We selected most functions Ephb3 had, and list some proteins which have the same functions with Ephb3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CIT; ABCA5; PKM2; ACSM4; MARK4; NME1; EGFR; PAK7; CDK17; STK10
Function axon guidance receptor activity
Related Protein ROBO1; SEMA5A; GFRA3; EPHB1; ROBO2; EPHA7; EPHB3
Function ephrin receptor activity
Related Protein EPHB4B; EK1; EPHA4B; EPHA10; EPHA4A; EPHA5; EPHA2; EPHB6; EPHA6; EPHB2B

Interacting Protein

Ephb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ephb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ephb3.
npm_alk; saicar; PKM; MLLT4; GBE1; NFRKB; purvalanol b

Ephb3 Related Articles

Ronsch, K; Jagle, S; et al. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. MOLECULAR ONCOLOGY 9:335-354(2015).
McLaughlin, T; Lim, YS; et al. Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1. MOLECULAR AND CELLULAR NEUROSCIENCE 63:24-30(2014).