esr1
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  • Official Full Name
  • estrogen receptor 1
  • Background
  • This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
  • Synonyms
  • ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1;
Cat.#:ESR1-118HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human ESR1 protein, His-tagged
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Cat.#:ESR1-1390HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ESR1 Protein (10-595 aa), His-tagged
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Cat.#:ESR1-3504HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ESR1 Protein, GST-tagged
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Cat.#:ESR1-102HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Estrogen alpha receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:ESR1-1033HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Estrogen Receptor 1
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Cat.#:ESR1-116HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Estrogen Receptor 1
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Cat.#:ESR1-117HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ESR1, His-tagged
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Cat.#:ESR1-121HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ESR1, GST-tagged
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Cat.#:ESR1-12557HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ESR1, GST-tagged
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Cat.#:ESR1-227HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human ESR1, StrepII-tagged
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Cat.#:ESR1-24HTag:
Source (Host):Insects cellSpecies:Human
Product nameRecombinant Human ESR1 Protein
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Cat.#:ESR1-2639HTag:N/A
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Estrogen Receptor 1
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Cat.#:ESR1-27977THTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ESR1, His-tagged
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Cat.#:ESR1-28401THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ESR1 protein
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Cat.#:ESR1-28402THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ESR1 protein, His-tagged
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Cat.#:ESR1-356HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ESR1 protein, His/MBP-tagged
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Cat.#:ESR1-784HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ESR1 Protein, His-tagged
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Cat.#:ESR1-8487HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human ESR1, His-tagged
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Cat.#:Esr1-1438MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Esr1 protein, His & GST-tagged
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Cat.#:Esr1-1439RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Esr1 protein, His & GST-tagged
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Cat.#:ESR1-2151RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ESR1 Protein
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Cat.#:ESR1-6738CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ESR1
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Cat.#:ESR1-9425ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ESR1
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Cat.#:ESR1-6540HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ESR1 293 Cell Lysate
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Involved Pathway

ESR1 involved in several pathways and played different roles in them. We selected most pathways ESR1 participated on our site, such as Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Estrogen signaling pathway
GNAS; HSP90AB1; HSPA8; MAP2K2; HSPA1L; CREB3L3; GNAO1; ATF6B; PLCB2; KRAS
Prolactin signaling pathway
SOCS1; SOCS2; RAF1; PRL; SHC1; STAT5A; RELA; MAPK11; INS; MAPK3
Thyroid hormone signaling pathway
ESR1; RXRA; RAF1; RCAN2; AKT1; PIK3CG; SLCO1C1; MED4; WNT4; PRKCA
Endocrine and other factor-regulated calcium reabsorption
ATP1B2; ATP1A1; ESR1; SLC8A1; KLK1B24; PLCB3; TRPV5; KLK1B9; DNM2; ATP1B3
Proteoglycans in cancer
WNT5B; SMO; FZD7; WNT6; PAK1; THBS1; MAP2K2; PIK3CB; PLCG2; ITGA2

Protein Function

ESR1 has several biochemical functions, for example, ATPase binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESR1 itself. We selected most functions ESR1 had, and list some proteins which have the same functions with ESR1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein DERL1; ESR1; Ar; RAB4A; ATP6V0A2B; ATXN3; RALB; LCK; WFS1; SDF2L1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ETV2; RFX5; ZNF713; ETV6; NEUROG3; AEBP2; EBF2; PYDC3; TTC6; ZNF148
Function RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
Related Protein ESR1; ESR2A; ESR2B
Function beta-catenin binding
Related Protein LZTS2A; ASH2L; AXIN1; KLF4; CARM1; NF2; APC; EP300; GLI3; CHD8
Function chromatin binding
Related Protein POU4F2; UBTF; MSL1A; HDAC2; ATF5; RERE; PAF1; TAL1; KDM6B; SREBF1
Function core promoter sequence-specific DNA binding
Related Protein KLF10; SOX9; THRAP3; PROX1; MLL1; MYOCD; RORA; SOHLH1; NR1D1; ESR1
Function enzyme binding
Related Protein GOLPH3; GSTM3; HLCS; CCND1; TP53; MAPK8; ESR2; PLCB1; SPDL1; TARBP2
Function estrogen receptor activity
Related Protein ESR2; ESR2A; NKX3-1; LEF1; ESR2B; GPR30; ESR1; NKX3
Function estrogen response element binding
Related Protein ESR2; TRIM24; ESR1; TOX3
Function identical protein binding
Related Protein HSPB8; PRPF3; DVL1; ACPP; SQSTM1; GCC2; GSTM3; MMP9; ADIPOQ; KRTAP10-5
Function nitric-oxide synthase regulator activity
Related Protein CALM2; HSP90AA1; HSP90AA1.1; AKT1; CALM1; CALM3; HSP90AB1; ESR1
Function protein binding
Related Protein FCHSD2; AGAP2; CDKL3; HLA-A; C1orf189; PARP4; HDAC3; KCNA4; LAMP2; CHRD
Function steroid binding
Related Protein ESR2A; CYP3A4; UGT1A1; PGR; PAQR7B; CYP21A1; CYP21A2; PAQR5B; HSD11B2; SERPINA6
Function steroid hormone receptor activity
Related Protein NR5A5; RORB; RORCA; RARG; NR2F1A; NR2F6A; NR5A1B; ESRRA; NR2F1B; ESRRG
Function transcription factor activity, sequence-specific DNA binding
Related Protein CREB5; FOXL1; OTX1A; GLI4; KDM5B; CTCF; MAFBB; IRF5; SOX5; ELK4
Function transcription factor binding
Related Protein DR1; MED12L; TCF7L2; NR0B2A; ARID5A; SLC26A5; FOXC1; HDAC2; MAPK1; BCL3
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NFIB; SOX4; ONECUT1; TBX20; NFYC; SMAD4; NFIC; SOX9; NEUROG3; FOSB
Function zinc ion binding
Related Protein BLVRA; BRF1; ANKIB1A; TRIM43; TRIM35; FTR72; ACE2; QPCT; CA5; KMT2E

Interacting Protein

ESR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESR1.
NCOA1; DDX5

ESR1 Related Articles

Yu, T; Zhou, ZC; et al. A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor. CANCER LETTERS 346:94-103(2014).
Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).