| Official Full Name | estrogen receptor 1 |
| Background | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] |
| Synonyms | ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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ESR1 involved in several pathways and played different roles in them. We selected most pathways ESR1 participated on our site, such as Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen signaling pathway | PLCB2; PLCB1; PIK3R2; ATF4; GABBR2; GNAO1; PIK3CA; Adcy4; CALML3; GRB2 |
| Prolactin signaling pathway | RAF1; GRB2; SHC3; TNFRSF11A; PIK3R1; IRF1; PRL; NRAS; FOXO3; SLC2A2 |
| Thyroid hormone signaling pathway | PIK3R2; ATP1A1; ATP1B1; ITGB3; HDAC1; MED27; PRKCA; NOTCH2; PLCG2; WNT4 |
| Endocrine and other factor-regulated calcium reabsorption | ATP1A1; PRKACB; KLK2; ATP1B3; PRKCB; PLCB1; KLK1B8; ATP1B4; KLK1B24; VDR |
| Proteoglycans in cancer | MAP2K1; RRAS; CBLB; ARAF; TLR2; LUM; WNT5B; TRP53; CDC42; PIK3R3 |
ESR1 has several biochemical functions, for example, ATPase binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESR1 itself. We selected most functions ESR1 had, and list some proteins which have the same functions with ESR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase binding | TAF9; GABARAPL2; FBL; BBC3; S100A1; TCIRG1; PIH1D1; DNAJB1; ANK1; ATP6V1G1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF257; CEBPE; ZSCAN21; MIXL1; ZNF543; NKX3-2; ATF7; NPAS4; ELK1; ETS2 |
| RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1; ESR2A; ESR2B |
| beta-catenin binding | TCF7; LZIC; GRIP1; CTNNA3; TAX1BP3; PTBP3; CDH24; CDH2; HDAC6; CBY1 |
| chromatin binding | BAP1; KDM6B; CUX1; ATXN7; TCF7L1B; CRX; SSBP1; ASH1L; CENPA; HDAC7 |
| core promoter sequence-specific DNA binding | SOHLH2; CHD2; ZFHX3; GATA3; PROX1; SP1; ATF4; TRP53; H2AFY; MTA1 |
| enzyme binding | H2AFX; APBA3; HIST1H2AM; LAMB1; ZNHIT6; SPDL1; RPS2; EIF4E; BCR; SRC |
| estrogen receptor activity | ESR2; NKX3; ESR1; LEF1; NKX3-1; GPR30; ESR2A; ESR2B |
| estrogen response element binding | TRIM24; TOX3; ESR2; ESR1 |
| identical protein binding | BCL2L1; CLDN8; UBQLN1; FXR2; DNM1L; SH3GL2; PRKD1; SHMT2; ST13; KCNJ10 |
| nitric-oxide synthase regulator activity | HSP90AB1; CALM2; ESR1; AKT1; HSP90AA1; HSP90AA1.1; CALM1; CALM3 |
| protein binding | FCN2; BTG3; NTF3; UBR1; PLAU; MKI67; FAM123A; LIN7A; MKI67IP; C14orf169 |
| steroid binding | ESRRG; HSD17B10; PGRMC2; PAQR7; PAQR7A; PAQR5A; CYP21A2; ESR2A; FAM84B; GPR30 |
| steroid hormone receptor activity | ESRRA; NR0B2; PPARDB; NR5A5; PPARAA; NR1D2B; RARAB; NR2F6B; PPARAB; THRAA |
| transcription factor activity, sequence-specific DNA binding | FOS; CBFB; POU3F2; PCGF2; ZFY2; HOXA2B; ZNF131; HOXB4A; CEBP1; FOXA1 |
| transcription factor binding | HES2; CDK9; NFYC; HES4; LCOR; HES6; MYOCD; SMARCA4; JUNB; MSX2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ONECUT2; TCF21; CEBPA; PAX8; MYBL1; ISL1; PAX5; NR5A2; CEBPZ; HNF4A |
| zinc ion binding | RORB; MTA1; BMI1B; MSL2A; TRIM2; TGFB1I1; NANOS2; DTNA; ADAM19; CNBPA |
ESR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESR1.
NCOA1; DDX5
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