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Recombinant Human ESR1 Protein (10-595 aa), His-tagged

Cat.No. : ESR1-1390H
Product Overview : Recombinant Human ESR1 Protein (10-595 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Transcription. Protein Description: Partial.
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Description : Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response elent (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response elent of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elents; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates mbrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 67.2 kDa
Protein length : 10-595 aa
AA Sequence : SGMALLHQIQGNELEPLNRPQLKIP LERPLGEVYLDSSKPAVYNYPEGAA YEFNAAAAANAQVYGQTGLPYGPGS EAAAFGSNGLGGFPPLNSVSPSPLM LLHPPPQLSPFLQPHGQQVPYYLEN EPSGYTVREAGPPAFYRPNSDNRRQ GGRERLASTNDKGSMAMESAKETRY CAVCNDYASGYHYGVWSCEGCKAFF KRSIQGHNDYMCPATNQCTIDKNRR KSCQACRLRKCYEVGMMKGGIRKDR RGGRMLKHKRQRDDGEGRGEVGSAG DMRAANLWPSPLMIKRSKKNSLALS LTADQMVSALLDAEPPILYSEYDPT RPFSEASMMGLLTNLADRELVHMIN WAKRVPGFVDLTLHDQVHLLECAWL EILMIGLVWRSMEHPGKLLFAPNLL LDRNQGKCVEGMVEIFDMLLATSSR FRMMNLQGEEFVCLKSIILLNSGVY TFLSSTLKSLEEKDHIHRVLDKITD TLIHLMAKAGLTLQQQHQRLAQLLL ILSHIRHMSNKGMEHLYSMKCKNVV PLYDLLLEMLDAHRLHAPTSRGGAS VEETDQSHLATAGSTSSHSLQKYYI TGEAEGFPATV
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : ESR1 estrogen receptor 1 [ Homo sapiens ]
Official Symbol : ESR1
Synonyms : ESR1; ESR; Era; NR3A1; ER-alpha; ER; ESRA; DKFZp686N23123;
Gene ID : 2099
mRNA Refseq : NM_000125
Protein Refseq : NP_000116
UniProt ID : P03372

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the clinical implications of ESR1 mutations in breast cancer? 04/13/2023

ESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.

How does ESR1 testing impact the prognosis of breast cancer patients? 10/02/2022

ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.

How is ESR1 protein detected in clinical practice? 09/27/2021

ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.

Can ESR1 mutations be targeted in breast cancer treatment? 02/23/2021

Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.

How is ESR1 status determined in breast cancer patients? 05/05/2019

ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.

Customer Reviews (3)

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Reviews
05/30/2021

    Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

    04/24/2019

      Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

      12/08/2017

        With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

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