EXT2

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EXT2

Official Full Name exostosin 2
Background EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses.
Synonyms EXT2; exostosin 2; exostoses (multiple) 2; exostosin-2; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; SOTV; multiple exostoses protein 2; putative tumor suppressor protein EXT2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EXT2-12604H Recombinant Human EXT2, GST-tagged E.coli GST
    Human EXT2-3585H Recombinant Human EXT2 Protein, GST-tagged Wheat Germ GST
    Human EXT2-6496HCL Recombinant Human EXT2 293 Cell Lysate HEK293 N/A
    Mouse EXT2-5392M Recombinant Mouse EXT2 Protein Mammalian Cell His
    Chicken EXT2-3003C Recombinant Chicken EXT2 Mammalian Cell His
    Zebrafish EXT2-1866Z Recombinant Zebrafish EXT2 Mammalian Cell His

    EXT2 involved in several pathways and played different roles in them. We selected most pathways EXT2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST1A; GLCE; HS6ST3; EXT1B; HS3ST3B1; B4GALT7; HS3ST1; HS6ST2; HS6ST1; HS3ST2
    Metabolic pathways FUT7; HSD17B6; ATP5I; PLCD1B; GCH2; HPSE2; PCK2; PTGS1; POLR3C; ENO1A

    EXT2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by EXT2 itself. We selected most functions EXT2 had, and list some proteins which have the same functions with EXT2. You can find most of the proteins on our site.

    Function Related Protein
    N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity EXT1B; EXT1A; EXT2; EXT1; EXT1C
    contributes_to acetylglucosaminyltransferase activity EXT2
    glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity EXT1A; EXT1; EXT1B; EXT2; EXT1C; EXTL1
    glucuronosyltransferase activity UGT1A4; UGT5F1; UGT5A4; UGT2A5; UGT5A2; UGT8; UGT1B4; UGT1A3; UGT5E1; B3GAT3
    heparan sulfate N-acetylglucosaminyltransferase activity EXT1; EXT2
    metal ion binding MMP14A; MGAT4B; TESK2; LIMCH1A; TROVE2; PRDM14; BCL11AA; ZFP503; HNRNPA0L; Car8
    protein heterodimerization activity TAF6; DDX1; ENO3; SOX4; PDGFB; STX1A; MYF5; ANO2; CAPN2; ALG2
    NOT protein homodimerization activity KCNA3; MYO9B; EXT2; MLXIPL; DDIT3; MSH6; NUDT16L1; MECOM; MSH3
    transferase activity, transferring glycosyl groups GLT1D1; GLT8D1; RFNG; UGT1B3; UGT2B6; EXT1B; GXYLT1B; UGT2B3; UGT5C3; B3GALTLB

    EXT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXT2.

    STK16; SNCG; FABP4; CNTF; HNF4A; RPS29; CRB1; TCEB1; HYOU1; SLC22A2; PFDN1; TK1; ANXA7; CDKN1A; SMN1; yapA; GSKIP

    Nadanaka, S; Kagiyama, S; et al. Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. BIOCHEMICAL JOURNAL 454:133-145(2013).
    Multhaupt, HAB; Couchman, JR; et al. Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:908-915(2012).

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