ext2
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  • Official Full Name
  • exostosin 2
  • Background
  • EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses.
  • Synonyms
  • EXT2; exostosin 2; exostoses (multiple) 2; exostosin-2; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; SOTV; multiple exostoses protein 2; putative tumor suppressor protein EXT2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Cat.#:EXT2-3585HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EXT2 Protein, GST-tagged
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Cat.#:EXT2-12604HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EXT2, GST-tagged
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Cat.#:EXT2-5392MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EXT2 Protein
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Cat.#:EXT2-3003CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EXT2
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Cat.#:EXT2-1866ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EXT2
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Cat.#:EXT2-6496HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EXT2 293 Cell Lysate
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Involved Pathway

EXT2 involved in several pathways and played different roles in them. We selected most pathways EXT2 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXT2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
HS6ST3; EXTL3; EXT1B; HS6ST2; HS2ST1A; HS3ST1; HS3ST3A1; HS6ST1A; NDST4; HS3ST5
Metabolic pathways
SDHDB; PPAP2CB; RPN2; NADKD1; HADHAB; ALDH3A1; GCSHA; HPRT1; MAN1B1; MVDA

Protein Function

EXT2 has several biochemical functions, for example, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity, contributes_to acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EXT2 itself. We selected most functions EXT2 had, and list some proteins which have the same functions with EXT2. You can find most of the proteins on our site.
Function
Related Protein
Function N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
Related Protein EXT1C; EXT2; EXT1B; EXT1; EXT1A
Function contributes_to acetylglucosaminyltransferase activity
Related Protein EXT2
Function glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
Related Protein EXT1C; EXT1A; EXTL1; EXT1B; EXT1; EXT2
Function glucuronosyltransferase activity
Related Protein CSGALNACT1; UGT5A1; UGT3A1; UGT1A7; UGT5E1; UGT2B3; UGT5B3; UGT5A2; B3GAT3; UGT1A6A
Function heparan sulfate N-acetylglucosaminyltransferase activity
Related Protein EXT2; EXT1
Function metal ion binding
Related Protein SMPD3; DAK; DGKQ; RBM26; OVOL1; HENMT1; POLD1; ZNF394; ZFP326; FRAS1
Function protein heterodimerization activity
Related Protein CRLF1; CYBB; PVALB; PIK3R2; MYO5A; H3F3B.1; GCA; ODZ4; JDP2; HER5
Function NOT protein homodimerization activity
Related Protein MSH3; KCNA3; NUDT16L1; MSH6; MLXIPL; MECOM; DDIT3; MYO9B; EXT2
Function transferase activity, transferring glycosyl groups
Related Protein GLT1D1; GLT25D2; UGT2A4; EOGT; MGAT3A; ST3GAL5L; UGT5C3; B3GAT1A; UGT1A6A; GLT8D1

Interacting Protein

EXT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXT2.
STK16; SNCG; FABP4; CNTF; HNF4A; RPS29; CRB1; TCEB1; HYOU1; SLC22A2; PFDN1; TK1; ANXA7; CDKN1A; SMN1; yapA; GSKIP

EXT2 Related Articles

Nadanaka, S; Kagiyama, S; et al. Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. BIOCHEMICAL JOURNAL 454:133-145(2013).
Multhaupt, HAB; Couchman, JR; et al. Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:908-915(2012).