epha4
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  • Official Full Name
  • EPH receptor A4
  • Background
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically h
  • Synonyms
  • EPHA4; EPH receptor A4; EphA4 , TYRO1; ephrin type-A receptor 4; Hek8; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8; SEK; TYRO1
Cat.#:EPHA4-3384HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHA4 Protein, GST-tagged
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Cat.#:EPHA4-3385HTag:GST|His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHA4 Protein, GST/His-tagged
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Cat.#:EPHA4-3386HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPHA4 Protein, GST-tagged
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Cat.#:EPHA4-1137HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPHA4 protein, His & GST-tagged
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Cat.#:EPHA4-26439THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EPHA4
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Cat.#:EPHA4-302HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor A4, GST-tagged, Active
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Cat.#:EPHA4-3204HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA4, His tagged
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Cat.#:EPHA4-366HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA4 Protein, DDK/His-tagged
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Cat.#:EPHA4-550HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human EPHA4 Protein, Fc Chimera
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Cat.#:EPHA4-7315HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHA4, His & GST tagged
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Cat.#:EPHA4-942HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA4, Fc-His tagged
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Cat.#:Epha4-1724MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Eph Receptor A4
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Cat.#:Epha4-912MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Epha4, Fc tagged
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Cat.#:Epha4-913MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Epha4, His tagged
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Cat.#:Epha4-7439RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Epha4, Fc tagged
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Cat.#:Epha4-7440RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Epha4, His tagged
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Cat.#:EPHA4-1175RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus EPHA4 Protein, Fc-tagged
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Cat.#:EPHA4-1176RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus EPHA4 Protein, His-tagged
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Cat.#:EPHA4-1484RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EPHA4 Protein, His-tagged
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Cat.#:EPHA4-6345CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EPHA4
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Cat.#:EPHA4-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHA4 cell lysate
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Cat.#:EPHA4-1933HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA4 cell lysate
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Cat.#:EPHA4-2136MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EPHA4 cell lysate
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Cat.#:EPHA4-1446RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EPHA4 cell lysate
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Cat.#:EPHA4-1192CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EPHA4 cell lysate
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Involved Pathway

Epha4 involved in several pathways and played different roles in them. We selected most pathways Epha4 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PLXND1; DUSP7; KCNQ2; Sema3f; COL6A2; NADL1.1; EPHA6; SPTBN1; SEMA4B; PAK4

Protein Function

Epha4 has several biochemical functions, for example, ATP binding, DH domain binding, GPI-linked ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha4 itself. We selected most functions Epha4 had, and list some proteins which have the same functions with Epha4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ERN1; ABCC8; DHX32A; FARSB; WARS2; PDK1; NEK5; MAP2K4; MCM5; TTLL9
Function DH domain binding
Related Protein EPHA4
Function GPI-linked ephrin receptor activity
Related Protein EPHA4; EPHA3; EPHA5; EPHA8; EK1; EPHA7
Function PH domain binding
Related Protein EPHA4; INPP5A; EPB41L2
Function ephrin receptor binding
Related Protein Anks1; EFNA2; EFNA2A; SRC; EPHA4; EFNB3B; EFNA1; SIPA1L1; EFNA3B; ANKS1B
Function identical protein binding
Related Protein PCNA; POU3F2; ASMT; GCC2; TNF; ATF3; CEACAM5; NELL2; SYNE1; CORO1B
Function protein binding
Related Protein SRF; FAM188A; POLR2A; CRHR1; COIL; COMP; PEX11G; CXXC1; MAGEB2; PHOSPHO2-KLHL23
Function protein kinase activity
Related Protein PIK3R4; IKBKAP; RLN1; AKT1; NEK12; RIPK1L; PKN3; MAP2K2A; DYRK3; KSR1
Function transmembrane-ephrin receptor activity
Related Protein EFNB3; EFNA4; EPHA10; EFNA3; EPHA1; EPHB2; EPHB1; EPHA4; EPHA5

Interacting Protein

Epha4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha4.
IKBKG; HSP90AB1

Epha4 Related Articles

Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
Kempf, A; Montani, L; et al. Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration. EUROPEAN JOURNAL OF NEUROSCIENCE 38:3567-3579(2013).