Epha4
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Official Full Name
EPH receptor A4
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Overview
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically h -
Synonyms
EPHA4; EPH receptor A4; EphA4 , TYRO1; ephrin type-A receptor 4; Hek8; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8; SEK; TYRO1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- Fc
- His
- hFc
- DDK|His
- GST
- GST|His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Epha4 Related Articles
Epha4 involved in several pathways and played different roles in them. We selected most pathways Epha4 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | RASGEF1A;PHB;Unc5b;COL6A2;GFRA1;RHOA;DPYSL4;SEMA4B;PAQR3A |
Epha4 has several biochemical functions, for example, ATP binding, DH domain binding, GPI-linked ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha4 itself. We selected most functions Epha4 had, and list some proteins which have the same functions with Epha4. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CLCN7;Abca2;MAP3K4;EPHA2A;CKMT2B;PI4KB;MKNK2B;YARS2;MAK |
DH domain binding | |
GPI-linked ephrin receptor activity | EK1;EPHA3;EPHA8;EPHA5;EPHA7;EPHA4 |
PH domain binding | EPHA4;INPP5A;EPB41L2 |
ephrin receptor binding | EFNB3B;EFNA5;EFNA1A;EPHA4;SIPA1L1;CRK;EFNA2A;EFNA1B;EFNB2B |
identical protein binding | TRIM55;SNX8;GRIN3A;NPR2;C1S;SIAH1A;FTL;ZNF212;S100B |
protein binding | YWHAB;UNC45B;TRAPPC2L;TTR;YAF2;SCO1;SPINLW1;HDAC6;SFRP1 |
protein kinase activity | TNK2B;INSRB;PAK2A;PRKACBA;SRPK1B;PRKCG;RPS6KAL;AKT1;EPHB3A |
transmembrane-ephrin receptor activity | EPHB1;EPHB2;EFNA3;EFNB3;EPHA5;EPHA4;EPHA1;EFNA4;EPHA10 |
Epha4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha4.
IKBKG; HSP90AB1
- Q&As
- Reviews
Q&As (7)
Ask a questionEPHA4 is a member of the ephrin receptor family of protein kinases that plays an important role in neural development and synaptic plasticity. It is involved in axon guidance, neuronal migration, and cell proliferation.
EPHA4 plays a critical role in neuronal development as a member of the Eph receptor family, which are receptor tyrosine kinases involved in various cellular processes. Specifically, EPHA4 regulates axon growth and guidance, acting as a repulsive cue to guide axons in the developing nervous system. Its involvement extends to synaptic plasticity and neuronal survival. Dysregulation of EPHA4 has been linked to neurological disorders, including Alzheimer's disease and neuropathic pain. Further research on the precise mechanisms and downstream signaling pathways of EPHA4 will deepen our understanding of its role in neuronal development and potential therapeutic applications.
EPHA4 expression is tightly regulated during nervous system development, with its expression gradually increasing during embryonic development. Additionally, EPHA4 expression is spatially regulated, with high levels in specific regions of the nervous system. Regulation of EPHA4 expression is mediated by several mechanisms, including transcriptional and post-transcriptional mechanisms.
EPHA4 is essential for normal synaptic plasticity, with its activation leading to the modulation of various synaptic proteins, such as AMPA receptors, NMDA receptors, and EphB receptors. Dysregulation of EPHA4-mediated signaling has been implicated in multiple neurodegenerative disorders, affecting both synaptic plasticity and axon growth.
EPHA4 signaling is initiated by binding to its ligands, which leads to activation of downstream signaling pathways. Several signaling pathways are activated by EPHA4, including the MAP kinase pathway, the PI3K-Akt pathway, and the RhoA-ROCK pathway, which play critical roles in the regulation of actin cytoskeleton dynamics.
EPHA4 has emerged as a promising therapeutic target for various neurodegenerative diseases, and several pharmacological inhibitors have been developed to target EPHA4 signaling. These inhibitors have shown efficacy in preclinical models of several neurodegenerative diseases, suggesting their potential in clinical applications.
There is growing evidence that genetic variants in the EPHA4 gene may contribute to the susceptibility to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. These variants have been shown to modify EPHA4 expression and function, and may contribute to disease pathogenesis via several mechanisms, including synaptic dysfunction and axon degeneration.
Customer Reviews (3)
Write a reviewThe results interpretation process with this protein reagent is straightforward, making it suitable for beginners as well.
The composition ratio of the reagent is highly accurate, ensuring the reliability of the experimental results.
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