• Official Full Name
  • coagulation factor VII (serum prothrombin conversion accelerator)
  • Background
  • Factor VII (formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme (EC of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog alfa [activated]) has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients. It is often used unlicensed in severe uncontrollable bleeding, although there has been safety concerns.
  • Synonyms
  • F7; coagulation factor VII; SPCA; eptacog alfa; proconvertin; OTTHUMP00000018733; OTTHUMP00000018734; FVII coagulation protein; serum prothrombin conversion accelerator; factor VII
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F7 Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human F7 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human F7 protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human F7
Source (Host):HEK293Species:Human
Product nameRecombinant Human F7, His tagged
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human F7 Protein, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse F7 protein, His-tagged
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse F7, His tagged
Source (Host):CHO Stable CellsSpecies:Mouse
Product nameRecombinant Mouse F7 Protein, His-tagged
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse F7, His-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat F7 protein, His & GST-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat F7 protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat F7 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey F7 Protein, His-tagged
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit F7 protein, His & T7-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken F7
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish F7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle F7 protein, His & GST-tagged
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Coagulation Factor VII (serum prothrombin conversion accelerator)
Source (Host):HEK293Species:Human
Product nameRecombinant Human F7 cell lysate
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse F7 cell lysate
Source (Host):Species:Human
Product nameHuman Blood Coagulation Factor VIIa Reference standard
Source (Host):Species:Human
Product nameHuman Factor VII Reference standard
Source (Host):Hamster kidney cellsSpecies:Human
Product nameRecombinant Human F7 therapeutic protein

Involved Pathway

F7 involved in several pathways and played different roles in them. We selected most pathways F7 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
SERPIND1; C1QA; F5; C8A; LOC100514666; SERPINA1; CR1; F13A1; C9; GM5077

Protein Function

F7 has several biochemical functions, for example, calcium ion binding, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F7 itself. We selected most functions F7 had, and list some proteins which have the same functions with F7. You can find most of the proteins on our site.
Related Protein
Function calcium ion binding
Related Protein CAPN3B; TLL2; MMP19; EHD1B; Npnt; BGLAP-RS1; NCL; AASS; CALR3B; MBL2
Function glycoprotein binding
Related Protein FBXO6; BBC3; EDEM2; SHB; B2M; LRRK2; RASA1; SDC1; CANX; FYN
Function protein binding
Related Protein CHN1; TMEM190; MEGF6; PSMD5; PSKH1; FES; BBS7; FAM59A; LTA4H; SIL1
Function receptor binding
Related Protein MCHR1; GSDMA2; CDH5; TAC1; PVRL4; LYN; NTF7; FLT3LG; CADM1B; RIPK2
Function serine-type endopeptidase activity
Related Protein TPSG1; PRSS2; GZMM; PCSK9; CORIN; Gzmg; PRSS48; ELA2; F9B; FURINB
Function serine-type peptidase activity
Related Protein Reln; TMPRSS11F; Prss32; TMPRSS11G; KLK1B3; TMPRSS4B; PARLA; Acr; DPP9; F9A

Interacting Protein

F7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F7 here. Most of them are supplied by our site. Hope this information will be useful for your research of F7.
F3; capsh_ade05; DMWD; USP49; UIMC1; IKBKG; RCHY1; ALB; BECN1; SLX4; GABARAPL1

F7 Related Articles

Guo, HJ; Cruz-Munoz, ME; et al. Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells. MOLECULAR AND CELLULAR BIOLOGY 35:41-51(2015).
Balasa, B; Yun, R; et al. Elotuzumab enhances natural killer cell activation and myeloma cell killing through interleukin-2 and TNF-alpha pathways. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:61-73(2015).

F7 Related Gene Family

IL TGF Kinesins (KIF) Cytokines