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F7

  • Official Full Name

    coagulation factor VII (serum prothrombin conversion accelerator)

  • Overview

    Factor VII (formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme (EC 3.4.21.21) of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog alfa [activated]) has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients. It is often used unlicensed in severe uncontrollable bleeding, although there has been safety concerns.
  • Synonyms

    F7; coagulation factor VII; SPCA; eptacog alfa; proconvertin; OTTHUMP00000018733; OTTHUMP00000018734; FVII coagulation protein; serum prothrombin conversion accelerator; factor VII;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Therapeutic Proteins
  • Antibody
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • Hamster Kidney
  • HEK293
  • HEK293T
  • Human Cell
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F7-720H Active Recombinant Human F7 Protein, His-tagged Mammalian cells His Ala39-Pro444
Human F7-3908H Active Recombinant Human F7 protein, His-tagged HEK293 His Ala 61 - Pro 466
Human F7-28711TH Recombinant Human F7 N/A
Human F7-3622H Recombinant Human F7 Protein, GST-tagged Wheat Germ GST
Human F7-3907H Recombinant Human F7 protein, His-tagged HEK293 His Met1-Pro444
Human F7-1911H Recombinant Human F7 protein, His-tagged E.coli His Ala334~Arg452 (Accession # P08709)
Human F7-1973HCL Recombinant Human F7 cell lysate Human Cell N/A
Human F7-24H Human Blood Coagulation Factor VIIa Reference standard N/A
Human F7-530H Recombinant Human F7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human F7-39H Human Factor VII Reference standard N/A
Human F7-5303H Native Human Coagulation Factor VII (serum prothrombin conversion accelerator) Human Plasma N/A
Human F7-959H Recombinant Human F7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human F7-2880H Recombinant Human F7 protein, His-SUMO-tagged E.coli His-SUMO 61-212aa
Human F7-2893H-B Recombinant Human F7 Protein Pre-coupled Magnetic Beads HEK293
Human F7-4500HF Recombinant Full Length Human F7 Protein, GST-tagged In Vitro Cell Free System GST 444 amino acids
Human F7-5400H Recombinant Human F7 protein, His-tagged Yeast His 61-212aa
Human F7-2308H Recombinant Human F7 Protein (Ala334-Arg452), His tagged E.coli His Ala334-Arg452
Human F7-2893H Recombinant Human F7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human F7-P042H Recombinant Human F7 therapeutic protein Hamster Kidney N/A 406 aa
Mouse F7-828M Active Recombinant Mouse F7 Protein, His-tagged CHO His
Mouse F7-1912M Recombinant Mouse F7 protein, His-tagged E.coli His Ala42~Lys169 (Accession # P70375)
Mouse F7-2206M Active Recombinant Mouse F7 protein(Met1-Leu446), His-tagged CHO C-His Met1-Leu446
Mouse F7-8662M Recombinant Mouse F7, His-tagged Human Cell His
Mouse F7-001MCL Recombinant Mouse F7 cell lysate CHO N/A
Mouse CAB11538RM Rabbit Anti-Mouse FVII protein Monoclonal Antibody Rabbit N/A
Mouse F7-1000M Recombinant Mouse F7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat F7-1914R Recombinant Rat F7 protein, His-tagged E.coli His Ala315~Asp433
Rat F7-1913R Recombinant Rat F7 protein, His & GST-tagged E.coli His/GST Ala42~Lys169
Rat F7-2180R Recombinant Rat F7 Protein Mammalian Cell His
Rat F7-911R Recombinant Rat F7 Protein, His&GST-tagged E.coli N-His&GST Ile194-Leu446
Rat F7-1837R Recombinant Rat F7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat F7-1837R-B Recombinant Rat F7 Protein Pre-coupled Magnetic Beads HEK293
Rabbit F7-1915R Recombinant Rabbit F7 protein, His & T7-tagged E.coli His/T7 Ala40~Arg191 (Accession # P98139)
Cattle F7-1910C Recombinant Cattle F7 protein, His & GST-tagged E.coli His/GST Ile193~Pro447 (Accession # P22457)
Rhesus Macaque F7-1532R Recombinant Rhesus monkey F7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque F7-1357R Recombinant Rhesus Macaque F7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque F7-1357R-B Recombinant Rhesus Macaque F7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish F7-9330Z Recombinant Zebrafish F7 Mammalian Cell His
Chicken F7-6012C Recombinant Chicken F7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • F7 Related Articles
  • F7 Related Gene Family
  • F7 Related Research Area

F7 involved in several pathways and played different roles in them. We selected most pathways F7 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSerpina1b;C6;C1R;C4BPA;C4A;PLG;F8;CFB;PLAUR

F7 has several biochemical functions, for example, calcium ion binding, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F7 itself. We selected most functions F7 had, and list some proteins which have the same functions with F7. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPRRG3;CD248;PCDH2AB9;ACTN1;SDF4;PCDH1GC6;VCAN;TBC1D8B;CDH16
glycoprotein bindingFLNA;F7;STX1A;ERLEC1;TGFB1;VIM;CNTN1;EDEM1;ITGAM
protein bindingITGB5;KTI12;IFT20;HNRNPF;ILVBL;NCDN;FAM125A;PDIK1L;PARVG
receptor bindingGSTK1;GSTM7;TESPA1;BMP2;HAND2;SLC9A3R2;DIAPH1;RSPO3;AGRP2
serine-type endopeptidase activityPRSS38;ST14A;Prss32;C1RA;CFD;PRSS46;APEH;KLK14;PRSS54
serine-type peptidase activityTMPRSS12;NAALAD2;Acr;KLK10;KLK1B26;TMPRSS7;TMPRSS13A;F7;GZMC

F7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F7 here. Most of them are supplied by our site. Hope this information will be useful for your research of F7.

F3; capsh_ade05; DMWD; USP49; UIMC1; IKBKG; RCHY1; ALB; BECN1; SLX4; GABARAPL1

Guo, HJ; Cruz-Munoz, ME; et al. Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells. MOLECULAR AND CELLULAR BIOLOGY 35:41-51(2015).
Balasa, B; Yun, R; et al. Elotuzumab enhances natural killer cell activation and myeloma cell killing through interleukin-2 and TNF-alpha pathways. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:61-73(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does F7 contribute to hemostasis, and what is its role in preventing excessive bleeding? 04/02/2021

Factor VII's role in the coagulation cascade ensures rapid initiation of clot formation, preventing excessive bleeding and contributing to hemostasis.

Discuss the role of F7 in the extrinsic pathway of blood coagulation. 07/20/2020

Factor VII is a key player in the extrinsic pathway, where it forms a complex with tissue factor to activate factor X, initiating the cascade leading to thrombin generation.

What are the mechanisms of F7 activation, and how is it regulated at the molecular level? 01/15/2019

Factor VII is activated through a proteolytic cleavage, converting it into its active form (VIIa). This activation is regulated by tissue factor and other coagulation factors.

Explain the biochemical basis of F7 deficiency and its implications for bleeding disorders. 11/05/2018

F7 deficiency results in impaired blood clotting, leading to a bleeding disorder known as coagulation factor VII deficiency. This condition can manifest in varying degrees of severity.

Explain the role of F7 in the coagulation cascade and blood clot formation. 09/28/2018

Factor VII is activated to its enzymatically active form (factor VIIa) and initiates the coagulation cascade by activating factor X, ultimately leading to the formation of a stable blood clot.

Customer Reviews (3)

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Reviews
05/18/2022

    Quick turnaround—this product arrived swiftly, facilitating our research.

    10/03/2019

      Exceptional quality and precision—our lab relies on this protein consistently.

      05/29/2018

        Invaluable assistance from customer service—professional and responsive.

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