FANCC Protein, Fanconi anemia, complementation group C


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Official Full Name Fanconi anemia, complementation group C
Background The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.
Synonyms FANCC; Fanconi anemia, complementation group C; FACC; Fanconi anemia group C protein; FA3; FAC; FLJ14675
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FANCC-497H Recombinant Human FANCC Protein (1-558 aa), His-SUMO-tagged E.coli His/SUMO
    Human FANCC-12737H Recombinant Human FANCC, GST-tagged E.coli GST
    Human FANCC-3828H Recombinant Human FANCC Protein, GST-tagged Wheat Germ GST
    Human FANCC-6333HCL Recombinant Human FANCC 293 Cell Lysate HEK293 N/A
    Chicken FANCC-1724C Recombinant Chicken FANCC Mammalian Cell His
    Zebrafish FANCC-3813Z Recombinant Zebrafish FANCC Mammalian Cell His

    FANCC involved in several pathways and played different roles in them. We selected most pathways FANCC participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fanconi anemia pathway RPA2; FANCC; FANCM; RMI2; STRA13; TOP3B; RAD51C; POLK; FANCL; FUZ

    FANCC has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCC itself. We selected most functions FANCC had, and list some proteins which have the same functions with FANCC. You can find most of the proteins on our site.

    Function Related Protein
    protein binding BMP1; NF2; LCOR; CDH23; Ar; KCNRG; MSH3; CUEDC2; NUP205; TBC1D16

    FANCC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCC here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCC.

    FANCE; SPTAN1; HSP90B1; FANCA; CDK1; HSP90AB1; q96be0_human; FANCG; BUB1; EGFR; NRAS

    Mi, J; Qiao, F; et al. FANCG is phosphorylated at serines 383 and 387 during mitosis. MOLECULAR AND CELLULAR BIOLOGY 24:8576-8585(2004).
    Donahue, SL; Lundberg, R; et al. Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY 278:29487-29495(2003).

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