FBXO4 Protein, F-box protein 4


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Official Full Name F-box protein 4
Background This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
Synonyms FBXO4; F-box protein 4; F box only protein 4; F-box only protein 4; FBX4; DKFZp547N213; F box protein 4; F box protein Fbx4; FBXO 4; FLJ10141; F-box protein Fbx4
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Fbxo4-290M Recombinant Mouse Fbxo4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human FBXO4-3945H Recombinant Human FBXO4 Protein, GST-tagged Wheat Germ GST
    Human FBXO4-6295HCL Recombinant Human FBXO4 293 Cell Lysate HEK293 N/A
    Mouse FBXO4-5750M Recombinant Mouse FBXO4 Protein Mammalian Cell His

    FBXO4 involved in several pathways and played different roles in them. We selected most pathways FBXO4 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis ANAPC13; MGRN1A; UBE2D3; CUL1B; MGRN1; UBE2E1; HERC4; MAP3K1; UBE3A; CDC23

    FBXO4 has several biochemical functions, for example, protein binding, protein homodimerization activity, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO4 itself. We selected most functions FBXO4 had, and list some proteins which have the same functions with FBXO4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CBR4; CDC42BPA; STX4A; TRAF2; GSTM5; NMB; ZBTB2; TRIM15; ECSIT; TRIM17
    protein homodimerization activity RENBP; NLGN4X; S100A6; HLA-G; TESC; BMP7A; MTMR2; ACTN2; CECR1; ASGR1
    ubiquitin-protein transferase activity FBXO30B; HECW1B; RNF11; MGRN1; FBXO4; FBXL3; UBE2G2; PAX6; TRAF4B; CNOT4

    FBXO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO4.

    CUL1; YWHAE; SKP1; Ywhae; SKP1; 22046569; HSP90AB1; Ywhae; NEDD8

    Lee, EK; Lian, Z; et al. The FBXO4 Tumor Suppressor Functions as a Barrier to Braf(V600E)-Dependent Metastatic Melanoma. MOLECULAR AND CELLULAR BIOLOGY 33:4422-4433(2013).
    Zhou, F; Yan, H; et al. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:427-432(2013).

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