fgfr1op
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  • Official Full Name
  • FGFR1 oncogene partner
  • Background
  • This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
  • Synonyms
  • FGFR1OP; FGFR1 oncogene partner; FOP; Fibroblast growth factor receptor 1 oncogene partner; OTTHUMP00000017612; OTTHUMP00000017613
Cat.#:FGFR1OP-4125HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR1OP Protein, GST-tagged
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Cat.#:FGFR1OP-12879HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR1OP, GST-tagged
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Cat.#:FGFR1OP-496HTag:FC/His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR1OP, His-GST tagged
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Cat.#:FGFR1OP-6790HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR1 Oncogene Partner, His-tagged
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Cat.#:FGFR1OP-5861MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGFR1OP Protein
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Cat.#:FGFR1OP-524CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1OP Protein, His-tagged
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Cat.#:FGFR1OP-352ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGFR1OP
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Cat.#:FGFR1OP-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR1OP cell lysate
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Involved Pathway

FGFR1OP involved in several pathways and played different roles in them. We selected most pathways FGFR1OP participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1OP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Anchoring of the basal body to the plasma membrane
NPHP4; TCTN1; SSNA1; CEP135; CP110; ODF2B; DCTN1A; AKAP9; CEP152; DCTN2
Assembly of the primary cilium
CEP57; SCLT1; ATAT1; SSTR3; SETD6; PROL1; NEK2; CEP70; CLUAP1; IFT52
Cell Cycle
CDK5RAP2; TMPO; UIMC1; ORC3L; GINS2; CUL1B; YWHAQ; DPF1; MCM7; YWHAH
Cell Cycle, Mitotic
ZWINT; NUP50; DULLARD; SDCCAG8; VRK2; TUBG2; SET; CENPL; CDK11A; CTDNEP1A
Centrosome maturation
HAUS2; ACTR1A; TSGA14; CEP76; CEP78; DYNC1I2; NDE1; DCTN1; NINL; DCTN3
Disease
CTDP1; CHMP4C; TRIM24; COBRA1; TNKS; CDK8; MIB1; GCKR; HDAC6; FDXR
Diseases of signal transduction
RBP4; HEY1; TNKS2; TNKS; CDK8; TTR; STRA6; CDC37; FKBP1A; KREMEN2
FGFR1 mutant receptor activation
CPSF6; CUX1; FGFR1OP; TRIM24; FGFR1OP2; LRRFIP1; MYO18A

Protein Function

FGFR1OP has several biochemical functions, for example, protein binding, protein homodimerization activity, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1OP itself. We selected most functions FGFR1OP had, and list some proteins which have the same functions with FGFR1OP. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TBRG4; EBF1; FRA10AC1; RAB1B; ZNF622; ABCG8; LACTB2; MYO18A; GCKR; DPEP3
Function protein homodimerization activity
Related Protein NOS1; MECOM; CHRNA7; CIB2; IGJ; BLOC1S6; MAPK4; CDSN; DMRTC1B; ATPIF1
Function protein kinase binding
Related Protein CD3E; LCK; PTPN1; THY1; NPM1; ACSL3; RCC2; PRDX3; MAP2K3; CDKN2B
Function protein tyrosine kinase activity
Related Protein CSK; TNK1; IGF1R; DYRK1B; PTK2AB; YES1; EPHA2A; ROS1; EPHB2B; MATK
Function protein tyrosine kinase inhibitor activity
Related Protein GNB2L1; FGFR1OP; IBTK

Interacting Protein

FGFR1OP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1OP here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1OP.
VASP; CEP19; PPP2CB; CTGF; CEP350; PACS1; NAGK; CEP350; CCHCR1; Lrrcc1; TBC1D31; PCM1; CSPP1; CCDC14

FGFR1OP Related Gene Family

Cytokines