FGFR1OP

  • Official Full Name

    FGFR1 oncogene partner
  • Overview

    This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
  • Synonyms

    FGFR1OP;FGFR1 oncogene partner;FOP;Fibroblast growth factor receptor 1 oncogene partner;OTTHUMP00000017612;OTTHUMP00000017613

Recombinant Proteins

  • Human
  • Zebrafish
  • Cynomolgus
  • Mouse
  • E.coli
  • Mammalian Cells
  • Insect Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Fc
  • Non
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
FGFR1OP-12879H Recombinant Human FGFR1OP, GST-tagged E.coli Human GST 1-374a.a.
FGFR1OP-352Z Recombinant Zebrafish FGFR1OP Mammalian Cells Zebrafish His
FGFR1OP-496H Recombinant Human FGFR1OP, His-GST tagged Insect Cells Human Fc&His 2-379 a.a.
FGFR1OP-524C Recombinant Cynomolgus FGFR1OP Protein, His-tagged Mammalian Cells Cynomolgus His
FGFR1OP-5861M Recombinant Mouse FGFR1OP Protein Mammalian Cells Mouse His
FGFR1OP-6790H Recombinant Human FGFR1 Oncogene Partner, His-tagged E.coli Human His
FGFR1OP-001HCL Recombinant Human FGFR1OP cell lysate Insect Cells Human Non
FGFR1OP-1320H Recombinant Human FGFR1OP protein(Ala2-Ala379), His&GST-tagged Insect Cells Human GST&His Ala2-Ala379
FGFR1OP-268C Recombinant Cynomolgus Monkey FGFR1OP Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
FGFR1OP-268C-B Recombinant Cynomolgus Monkey FGFR1OP Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
FGFR1OP-3241M Recombinant Mouse FGFR1OP Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FGFR1OP-3241M-B Recombinant Mouse FGFR1OP Protein Pre-coupled Magnetic Beads HEK293 Mouse
FGFR1OP-4125H Recombinant Human FGFR1OP Protein, GST-tagged Wheat Germ Human GST
FGFR1OP-4887HF Recombinant Full Length Human FGFR1OP Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 379 amino acids

    Involved Pathway

    FGFR1OP involved in several pathways and played different roles in them. We selected most pathways FGFR1OP participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1OP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FGFR1 mutant receptor activation TRIM24,LRRFIP1,MYO18A,CPSF6,CUX1,FGFR1OP2
    Centrosome maturation TUBG2,CLASP1A,DYNC1I2,CETN2,PLK4,TUBGCP2,DCTN1,CEP63,CP110,CEP164
    Anchoring of the basal body to the plasma membrane MKS1,TUBB4B,CENPJ,RPGRIP1L,TUBG1,PCM1,ODF2B,DCTN1,CEP290,DCTN3
    Cell cycle NCAPD2,SETA,ABL1,SMAD3A,CLSPN,BRE,DSN1,MDM2,ORC4L,CSNK1D
    Cell Cycle, Mitotic CLASP1A,CETN2,DCTN3,VRK2,NIPBLA,STAG1,DHFR,LEMD3,ODF2,CDK6
    Disease TLR10,LRRFIP1,PACS1,gag,NMT1,ELL,TTR,HEY1,RPL35,EEF2
    Diseases of signal transduction CUX1,KREMEN1,MIB1,HEYL,TRAT1,HDAC5,RBP1,OPN1SW,CCNC,OPN1MW2
    Assembly of the primary cilium PKD2,NDE1,TRAF3IP1,KIF3C,DCTN1A,TMEM216,CCT3,CNGA2,ARL3,RAB3IP

    Protein Function

    FGFR1OP has several biochemical functions, for example, protein binding,protein homodimerization activity,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1OP itself. We selected most functions FGFR1OP had, and list some proteins which have the same functions with FGFR1OP. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine kinase inhibitor activity GNB2L1,IBTK
    protein tyrosine kinase activity KDRL,CAMKK2,FER,DYRK3,BLK,BCR,ERBB4,FGFR4,LCK,DSTYK
    protein kinase binding CAMK2N2,PXN,DVL1,TMEM173,TOM1L1,HCLS1,CCND1,DAXX,SHC3,ADCY6
    protein homodimerization activity CBS,MVD,GLIPR2,GDNFA,BOKA,PLD6,DAXX,APOE,SH3GLB1,SNX6
    protein binding ELK4,BRD3,PKD1,GFI1,AEBP2,CIC,KLF17,WAS,YWHAQ,SMARCE1

    Interacting Protein

    FGFR1OP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1OP here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1OP.

    VASP;CEP19;PPP2CB;CTGF;CEP350;PACS1;NAGK;CEP350;CCHCR1;Lrrcc1;TBC1D31;PCM1;CSPP1;CCDC14

    Resources

    Gene Families

    Research Area

    References

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