FKBP10
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Official Full Name
FK506 binding protein 10, 65 kDa
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Overview
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined. -
Synonyms
FKBP10; FK506 binding protein 10, 65 kDa; FK506 binding protein 10 (65 kDa); peptidyl-prolyl cis-trans isomerase FKBP10; FKBP6; FLJ20683; FLJ22041; FLJ23833; hFKBP65; 65 kDa FK506 binding protein; FK506 binding protein 10 65 kDa; FK506 binding protein 10; FKBP 10; FKBP 65; hFKBP 65; Immunophilin FKBP65; Peptidyl prolyl cis trans isomerase; PPIase; Rotamase; FKBP-10; FKBP-65; 65 kDa FKBP; PPIase FKBP10; OTTHUMP00000164742; OTTHUMP00000164743; FK506-binding protein 10; 65 kDa FK506-binding protein; OI6; FKBP65;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
FKBP10 involved in several pathways and played different roles in them. We selected most pathways FKBP10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
FKBP10 has several biochemical functions, for example, FK506 binding, calcium ion binding, peptidyl-prolyl cis-trans isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP10 itself. We selected most functions FKBP10 had, and list some proteins which have the same functions with FKBP10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FK506 binding | FKBP9;TTC9B;FKBP1AA;FKBP7;FKBP14;FKBP1AB;FKBP5;FKBP11;TTC9C |
| calcium ion binding | VIL1;CANT1A;RCVRNA;TC2N;F2;PADI1;SPTA1;TGM3;FREM2 |
| peptidyl-prolyl cis-trans isomerase activity | FKBP14;FKBP4;PPIC;FKBP10;PPIF;PPIL2;PPIL4;FKBP1AB;PPIFA |
FKBP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP10.
cona_canen; H2AFX; SLX1A
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression of FKBP10 is regulated by a variety of factors. For example, some growth factors, such as EGF and TGF-β, can induce their expression, while some drugs and other small molecule compounds can also affect their expression levels.
The protein can participate in the regulation of immune response by interacting with a variety of immune-related proteins. For example, it can exert immunosuppressive effects by inhibiting T cell activation and inflammatory responses.
FKBP10 can interact with a variety of proteins and molecules. For example, it can interact with HSP90 to form complexes to exert its functions, and it can also interact with a variety of immune-related molecules such as IL-2, IL-6, and IFN-γ to modulate immune responses.
It can promote angiogenesis. It promotes the formation of new blood vessels by promoting endothelial cell proliferation and migration, as well as inhibiting apoptosis of vascular endothelial cells.
FKBP10 can affect the apoptosis process through a variety of pathways. For example, it can inhibit NF-κB signaling, which inhibits cell survival signaling, and it can also promote the release of pro-apoptotic molecules such as cytochrome c from mitochondria.
It can interact with a variety of proteins, binding to target proteins through its FKBP12-like domain, thereby promoting protein folding and stability.
Customer Reviews (3)
Write a reviewThe quality is very good and in line with relevant industry standards.
FKBP10 has strong anti-pollution ability and is not easy to be polluted, which ensures the quality of the product.
When it is used in experiments, the results are accurate, reliable, and very reliable.
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