fkbp1b
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  • Official Full Name
  • FK506 binding protein 1B, 12.6 kDa
  • Background
  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
  • Synonyms
  • FKBP1B; FK506 binding protein 1B, 12.6 kDa; FK506 binding protein 1B (12.6 kD) , FKBP1L; peptidyl-prolyl cis-trans isomerase FKBP1B; FKBP9; FKBP12.6; OTK4; PPIase; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B 12.6 kDa; FK506 binding protein 1B; FK506-binding protein 1B; FKB1B_HUMAN; FKBP 12.6; FKBP 1B; FKBP 1L; FKBP 9; FKBP-12.6; FKBP-1B; FKBP1L; h FKBP 12; h-FKBP-12; Immunophilin FKBP12.6; OTK 4; Peptidyl prolyl cis trans isomerase 1B; Peptidyl prolyl cis trans isomerase; PKBP 1L; PKBP1L; PPIase 1B; PPIase FKBP1B; Rotamase 1B; Rotamase; OTTHUMP00000116040; OTTHUMP00000116041; FK506-binding protein 12.6; 12.6 kDa FK506-binding
Cat.#:FKBP1B-4187HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FKBP1B Protein, GST-tagged
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Cat.#:FKBP1B-5252HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP1B Protein
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Cat.#:FKBP1B-1522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FK506 Binding Protein 1B, 12.6 kDa, His-tagged
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Cat.#:FKBP1B-2500HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FK506 Binding Protein 1B, 12.6 KDa, His-tagged
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Cat.#:FKBP1B-28914THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP1B, His-tagged
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Cat.#:FKBP1B-2354RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FKBP1B Protein
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Cat.#:FKBP1B-1719RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FKBP1B Protein, His-tagged
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Cat.#:FKBP1B-6136CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FKBP1B
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Cat.#:FKBP1B-11068ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FKBP1B
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Cat.#:FKBP1B-6209HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FKBP1B 293 Cell Lysate
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Involved Pathway

FKBP1B involved in several pathways and played different roles in them. We selected most pathways FKBP1B participated on our site, such as Integrated Pancreatic Cancer Pathway, Ion channel transport, Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Integrated Pancreatic Cancer Pathway
RB1CC1; TOP1; FST; AGA; NOXA1; MAPK4; TOP2A; MYT1; CST3; CD82
Ion channel transport
TTYH3B; TRPC5A; CCC2; SLC17A3; CLCN4; CLCN5; TSC22D3; PDZD11; ATP1A1A.2; CLCNK
Stimuli-sensing channels
CLCNKA; CLCN2; GSDMA2; TRPV3; BEST4; ANO8; TRPC4A; TRPC4APA; SGK2; TRPM1
Transmembrane transport of small molecules
SLC17A7A; ATP2C2; SLC8A2A; SLCO3A1; SLC26A7; LCN2; ATP7B; SCNN1D; SLC12A1; SLC9A9

Protein Function

FKBP1B has several biochemical functions, for example, FK506 binding, calcium channel inhibitor activity, cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP1B itself. We selected most functions FKBP1B had, and list some proteins which have the same functions with FKBP1B. You can find most of the proteins on our site.
Function
Related Protein
Function FK506 binding
Related Protein FKBP10B; FKBP5; FKBP1B; FKBP1A; NFATC1; FKBP11; FKBP4; FKBPL; FKBP9; FKBP14
Function calcium channel inhibitor activity
Related Protein SLC30A1B; FKBP1AB; PHPT1; TNNI3; ITPR1; AMBP; SLC30A1A; CCDC109B; FKBP1B; PACSIN3
Function cyclic nucleotide binding
Related Protein CNP; FKBP1B
Function ion channel binding
Related Protein GPD1L; PHPT1; EPN1; DIAP1; KCNJ11; AKAP9; KCND3; CAMK2D; FGF13; NOS1
Function peptidyl-prolyl cis-trans isomerase activity
Related Protein PPID; FKBP1AA; PPWD1; FKBP8; PPIF; PPIAL4C; RANBP2; PPIL6; PPIC; PPIB
Function protein binding
Related Protein NOC2L; FAM117B; DAB2; ACTN2; DIS3L; SOCS5; MAGEA11; ARHGDIG; BTG1; MACROD1
Function receptor binding
Related Protein HSPA1A; CADM2A; FGF12A; SEMA4D; ICOSLG; RCHY1; TAC3; GLA; Icosl; TAC1
Function contributes_to ryanodine-sensitive calcium-release channel activity
Related Protein FKBP1B

Interacting Protein

FKBP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP1B.
RYR2; REL; CAMK2D; KRT31; FLJ13057; KRT40

FKBP1B Related Articles

Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
Francia, P; Adduci, C; et al. Common genetic variants in selected Ca2+ signaling genes and the risk of appropriate ICD interventions in patients with heart failure. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY 38:169-177(2013).