FOXC1 Protein, forkhead box C1


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Official Full Name forkhead box C1
Background This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
Synonyms FOXC1; forkhead box C1; ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3; forkhead box protein C1; myeloid factor-delta; forkhead box C1 protein; forkhead-related activator 3; forkhead-related protein FKHL7; forkhead, drosophila, homolog-like 7; forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FOXC1-4437H Recombinant Human FOXC1 Protein, GST-tagged Wheat Germ GST
    Human FOXC1-6161HCL Recombinant Human FOXC1 293 Cell Lysate HEK293 N/A
    Mouse FOXC1-5980M Recombinant Mouse FOXC1 Protein Mammalian Cell His
    Mouse Foxc1-7634M Recombinant Mouse Foxc1 protein, His-tagged E.coli His
    Chicken FOXC1-6564C Recombinant Chicken FOXC1 Mammalian Cell His

    FOXC1 involved in several pathways and played different roles in them. We selected most pathways FOXC1 participated on our site, such as Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Heart Development BMP10; FOXH1; FOXC1; GATA6; SMYD1; FOXC2; TBX20; HEY2; HEY1; NKX2

    FOXC1 has several biochemical functions, for example, DNA binding, DNA binding, bending, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXC1 itself. We selected most functions FOXC1 had, and list some proteins which have the same functions with FOXC1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ARID1A; ZNF518A; HOXB1A; PPARAB; SIX2B; TGIF2; ZBTB9; TEAD4; ZNF358; ZNF572
    DNA binding, bending HMGB1; HMGA2; TOP2A; FOXC1; LEF1; HMGB3; HMGB2; CRIP1; FOXD1; FOXD4
    RNA polymerase II regulatory region sequence-specific DNA binding DLX2; ZNF79; MYOG; FOXF1; XBP1; NFKB1; NFIL3; ATF3; AIRE; ACTN4
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXD1L; JUNB; FOXO3; ZNF202; TAL1; CC2D1B; FEV; FOXA3; FOXA1; FOXR2
    protein binding RPGR; SPG20; IL24; RB1CC1; MXD4; SNRPD3; ZFP346; RELL2; AZIN1; PACSIN3
    sequence-specific DNA binding NKX2.5; TCF7L1B; ELK4; IRX4A; GSC; DLX6; FOXP2; FOXF2A; GTF2E1; HOXA11
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding MYOD1; SPI1; MEIS1; RFX1; BHLHE40; USF1; NKX2-1; GATA5; NFATC1; MITF
    transcription factor activity, sequence-specific DNA binding RFX3; KLF11; ETV5; HOMEZ; HOXC6; ZNF187; RORCB; ZNF498; RCOR2; ZFP184
    transcription factor binding CD34; ERCC3; PPARGC1B; PSMC5; HDAC3; TFDP2; REST; AHR; KAT2A; STK36
    transcription regulatory region DNA binding HNF1A; NR1H3; WT1; SALL2; SALL1A; FOXA1; GABPA; XBP1; SMAD3; WNT1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MSX1; CSRNP3; OSR2; PPARG; REST; FOXF2; TRPS1; FOXC1; ZGLP1; MYF5

    FOXC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXC1.


    Sadagopan, KA; Liu, GT; et al. Anirdia-Like Phenotype Caused by 6p25 Dosage Aberrations. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:524-528(2015).
    Yoshimura-Furuhata, M; Nishimura-Tadaki, A; et al. Renal Complications in 6p Duplication Syndrome: Microarray-Based Investigation of the Candidate Gene(s) for the Development of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) and Focal Segmental Glomerular Sclerosis (FSGS). AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:592-601(2015).

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