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FXYD5

  • Official Full Name

    FXYD domain containing ion transport regulator 5

  • Overview

    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.
  • Synonyms

    FXYD5; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; dysadherin; OIT2; keratinocytes associated transmembrane protein 1; RIC; IWU1; KCT1; DYSAD; HSPC113; PRO6241;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FXYD5-7524H Recombinant Human FXYD5, His-tagged E.coli His 22-145aa
Human FXYD5-6098HCL Recombinant Human FXYD5 293 Cell Lysate HEK293 N/A
Mouse FXYD5-6107M Recombinant Mouse FXYD5 Protein Mammalian Cell His
Mouse FXYD5-3403M-B Recombinant Mouse FXYD5 Protein Pre-coupled Magnetic Beads HEK293
Mouse FXYD5-3403M Recombinant Mouse FXYD5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FXYD5-2424R Recombinant Rat FXYD5 Protein Mammalian Cell His
Rat FXYD5-2080R-B Recombinant Rat FXYD5 Protein Pre-coupled Magnetic Beads HEK293
Rat FXYD5-2080R Recombinant Rat FXYD5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mus musculus (Mouse) RFL7325MF Recombinant Full Length Mouse Fxyd Domain-Containing Ion Transport Regulator 5(Fxyd5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-178)
Rattus norvegicus (Rat) RFL10382RF Recombinant Full Length Rat Fxyd Domain-Containing Ion Transport Regulator 5(Fxyd5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-178)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FXYD5 Related Research Area

FXYD5 involved in several pathways and played different roles in them. We selected most pathways FXYD5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FXYD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

FXYD5 has several biochemical functions, for example, actin binding, cadherin binding, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FXYD5 itself. We selected most functions FXYD5 had, and list some proteins which have the same functions with FXYD5. You can find most of the proteins on our site.

Function Related Protein
actin bindingS100A4;ADD3;WASF1;TMOD2;PHACTR3A;CFL1;MYO10;WASF3B;EPB41L1
cadherin bindingCDK5R1;FER;VCL;CTNNB1;PSEN1;AKAP5;PROM1;NEO1;NDRG1
ion channel activityTRPC5A;ASIC4;CHRNB3B;SCN4AB;KCNC3B;GRIK3;TRPC7B;TRPM4A;CHRNB3
sodium channel regulator activityCAV3;SGK1;FXYD1;NEDD4L;GPLD1;FXYD2;RANGRF;FXYD7;SCN1BA

FXYD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXYD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXYD5.

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