FZD2
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Official Full Name
frizzled family receptor 2
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Overview
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. -
Synonyms
FZD2; frizzled family receptor 2; frizzled (Drosophila) homolog 2 , frizzled 2, seven transmembrane spanning receptor , frizzled homolog 2 (Drosophila); frizzled-2; Frizzled homolog 2; Frizzled2; Fz 2; Fz-2; Fz2; FZD 2; FZD2_HUMAN; FzE 2; FzE2; hFz 2; hFz2; frizzled 2, seven transmembrane spanning receptor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Xenopus laevis (African clawed frog)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Fc
- GST
- His
- His (Fc)
- Avi
- human|IgG1|Fc
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | FZD2-26287TH | Recombinant Human FZD2 | Wheat Germ | N/A | 54 amino acids |
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| Human | FZD2-13065H | Recombinant Human FZD2, GST-tagged | E.coli | GST | 138-217a.a. | |
| Human | FZD2-135H | Recombinant Human FZD2 protein, Fc-tagged | HEK293 | human/IgG1/Fc | Gln24-Ser156 |
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| Human | FZD2-321H | Recombinant Human FZD2 protein, Fc-tagged | HEK293 | human/IgG1/Fc | 167 |
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| Human | FZD2-4591H | Recombinant Human FZD2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | FZD2-2612H | Recombinant Human FZD2 protein, His-tagged | E.coli | His | 138-217 aa | |
| Human | FZD2-1437H | Recombinant Human FZD2 protein, Fc-tagged | HEK293 | Fc | Gln24-Ser156 |
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| Human | FZD2-255H | Recombinant Human FZD2 Protein, Fc-tagged | HEK293 | Fc | 565 |
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| Human | FZD2-1436H | Recombinant Human FZD2 protein, Fc-tagged | HEK293 | Fc | Gln24-Pro190 |
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| Mouse | Fzd2-585M | Active Recombinant Mouse Frizzled Homolog 2 (Drosophila), Fc-tagged | Mammalian cells | Fc |
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| Mouse | Fzd2-6055M | Recombinant Mouse Fzd2 Protein (Gln29-Leu168), C-Fc tagged | Mammalian cells | C-Fc | Gln29-Leu168 |
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| Mouse | Fzd2-380M | Recombinant Mouse Fzd2 Protein, Fc-tagged | HEK293 | Fc | Gln29-Leu168 |
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| Mouse | Fzd2-53M-B | Recombinant Mouse Fzd2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Fzd2-53M | Recombinant Mouse Fzd2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | FZD2-2429R | Recombinant Rat FZD2 Protein | Mammalian Cell | His |
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| Rat | FZD2-2085R-B | Recombinant Rat FZD2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | FZD2-2085R | Recombinant Rat FZD2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Gallus gallus (Chicken) | RFL12571GF | Recombinant Full Length Chicken Frizzled-2(Fzd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-523) |
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| Homo sapiens (Human) | RFL28554HF | Recombinant Full Length Human Frizzled-2(Fzd2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-565) |
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| Mus musculus (Mouse) | RFL2034MF | Recombinant Full Length Mouse Frizzled-2(Fzd2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (29-570) |
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| Xenopus laevis (African clawed frog) | RFL1807XF | Recombinant Full Length Xenopus Laevis Frizzled-2(Fzd2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-551) |
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| Zebrafish | FZD2-8756Z | Recombinant Zebrafish FZD2 | Mammalian Cell | His |
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| Chicken | FZD2-5795C | Recombinant Chicken FZD2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- FZD2 Related Gene Family
- FZD2 Related Research Area
- FZD2 Related Signal Pathway
FZD2 involved in several pathways and played different roles in them. We selected most pathways FZD2 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | PRKCA;RBX1;RAC1B;SOST;EP300;PPP3CCA;PRICKLE1A;DKK2;RAC1 |
| Hippo signaling pathway | SMAD3;JUB;GDF6;PPP1CC;GDF7;WNT16;DLG3;SMAD4;NF2 |
| Signaling pathways regulating pluripotency of stem cells | WNT3A;MAPK11;GSK3B;AKT2;HESX1;WNT11;IGF1R;LIFR;FGFR2 |
| Melanogenesis | GSK3B;KRAS;FZD8;FZD7;CALM2B;Kitl;TYR;CAMK2G1;EDNRBA |
| HTLV-I infection | MAP3K1;MSX2;WNT8A;MSX1;CDC26;DVL2;IL1R2;ANAPC7;WNT9B |
| Pathways in cancer | FGF8;PIK3R1;EP300;MMP1;Ar;RXRA;NFKB2;PDGFRB;BCL2 |
| Proteoglycans in cancer | TLR2;FLNA;MAPK13;ITPR1;WNT5A;Fasl;WNT2B;TWIST2;MAPK12 |
| Basal cell carcinoma | WNT8A;GSK3B;WNT5B;PTCH2;HHIP;FZD8;WNT1;WNT6;BMP2 |
FZD2 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD2 itself. We selected most functions FZD2 had, and list some proteins which have the same functions with FZD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | OXER1;GPR176;GPR31B;TAS2R121;GPR141;TAAR14J;TAAR12A;OLFR498;OR12D2 |
| PDZ domain binding | GJA1;DLG3;NKD1;ARHGEF16;CXADR;CXXC4;SLC9A3;ACCN3;KCNJ4 |
| Wnt-activated receptor activity | FZD9;FZD3A;FZD7;LRP2A;FZD8;FZD3B;FZD6;LRP6;FZD7A |
| Wnt-protein binding | GM12824;PTPRO;SZL;FZD7;LRP6;PORCN;APCDD1;FZD3;SFRP4 |
| protein binding | ATOX1;SYNGR1;RALYL;MRPL48;ZNF543;BMX;ECSIT;CASP6;GRAP2 |
FZD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD2.
Fyn; STAT3; C1qa
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