fzd2
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  • Official Full Name
  • frizzled family receptor 2
  • Background
  • This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
  • Synonyms
  • FZD2; frizzled family receptor 2; frizzled (Drosophila) homolog 2 , frizzled 2, seven transmembrane spanning receptor , frizzled homolog 2 (Drosophila); frizzled-2; Frizzled homolog 2; Frizzled2; Fz 2; Fz-2; Fz2; FZD 2; FZD2_HUMAN; FzE 2; FzE2; hFz 2; hFz2; frizzled 2, seven transmembrane spanning receptor
Cat.#:Fzd2-380MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fzd2 Protein, Fc-tagged
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Cat.#:FZD2-4591HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FZD2 Protein, GST-tagged
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Cat.#:Fzd2-585MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Frizzled Homolog 2 (Drosophila), Fc-tagged
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Cat.#:FZD2-321HTag:human|IgG1|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FZD2 protein, Fc-tagged
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Cat.#:FZD2-13065HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FZD2, GST-tagged
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Cat.#:FZD2-135HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FZD2, Fc-tagged
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Cat.#:FZD2-26287THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FZD2
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Cat.#:FZD2-2429RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FZD2 Protein
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Cat.#:FZD2-5795CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FZD2
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Cat.#:FZD2-8756ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FZD2
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Involved Pathway

FZD2 involved in several pathways and played different roles in them. We selected most pathways FZD2 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PRKACAB; TCF7L2; CUL1A; CACYBP; FZD9; WNT8A; CCND3; WNT11R; TBL1X; MAP3K7
Hippo signaling pathway
SCRIB; SMAD3; MOB1A; BMP2; DLG3; WWC1; AXIN2; SOX2; BTRC; SMAD1
Signaling pathways regulating pluripotency of stem cells
HOXB1; MEIS1; SETDB1; FGF2; PCGF1; ACVR1; TBX3; PIK3R1; MYF5; LEFTY2
Melanogenesis
MC1R; CALM1; Kitl; CAMK2B1; CALM1A; PRKCA; CREB3L3A; CALM2A; PRKCBB; GNAI3
HTLV-I infection
ITGAL; TP53INP1; WNT3; HLA-DRB3; MYBL1; FZD10; ANAPC11; TGFB3; SLC25A6; CCND1
Pathways in cancer
TCF7; FGF9; SMAD2; PIAS2; LPAR4; MLH1; FGF3; LPAR6; HSP90B1; RALB
Proteoglycans in cancer
SDC4; ROCK1; SOS1; WNT7A; MAPK11; CD44; SDC2; WNT1; ITGA5; TWIST1
Basal cell carcinoma
GSK3B; FZD9; TCF7L2; FZD7; SUFU; FZD5; BMP4; FZD1; FZD6; WNT9B

Protein Function

FZD2 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD2 itself. We selected most functions FZD2 had, and list some proteins which have the same functions with FZD2. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein MTNR1C; OR2B3; GPR31; TAAR15; PTGER4B; RXFP2A; PTGER2B; PTGER2A; FPR3; CHRM2A
Function PDZ domain binding
Related Protein GRASP; CIT; PTENB; FZD2; PARK2; KCNJ4; SLC9A3R1; SDC2; LPAR2; ACCN3
Function Wnt-activated receptor activity
Related Protein LRP5L; FZD7B; FZD3A; FZD5; FZD1; FZD9; FZD7; Fzd4; FZD3B; LRP5
Function Wnt-protein binding
Related Protein FRZB; LRP2A; SFRP1; FZD6; ROR1; SETD6; SFRP4; FZD5; SFRP1B; FZD7A
Function protein binding
Related Protein KCNH1; PDHB; TSEN2; LYL1; KRT6B; TRP53; SIK2; RECK; PRPF3; ATPAF2

Interacting Protein

FZD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD2.
Fyn; STAT3; C1qa

FZD2 Related Gene Family

GPCRs