g6pd
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  • Official Full Name
  • glucose-6-phosphate dehydrogenase
  • Background
  • This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • G6PD; glucose-6-phosphate dehydrogenase; G6PD1; glucose-6-phosphate 1-dehydrogenase;
Cat.#:G6PD-4615HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human G6PD Protein, GST-tagged
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Cat.#:G6PD-2397HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Glucose-6-phosphate Dehydrogenase, His-tagged
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Cat.#:G6PD-192HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glucose-6-Phosphate 1-Dehydrogenase
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Cat.#:G6PD-445HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human G6PD
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Cat.#:G6PD-710HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human G6PD protein, His-tagged
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Cat.#:G6PD-2437RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat G6PD Protein
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Cat.#:G6pd-712RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat G6pd protein, His-tagged
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Cat.#:G6PD-1784RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey G6PD Protein, His-tagged
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Cat.#:G6PD-26Tag:N/A
Source (Host):Bacillus sp.Species:Bacillus sp.
Product nameNative Glucose-6-phosphate dehydrogenase
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Cat.#:G6PD-6079HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human G6PD 293 Cell Lysate
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Cat.#:G6PD-6080HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human G6PD 293 Cell Lysate
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Involved Pathway

G6PD involved in several pathways and played different roles in them. We selected most pathways G6PD participated on our site, such as Pentose phosphate pathway, Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with G6PD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose phosphate pathway
ALDOCA; GPIB; RBKS; TKT; GPI1; FBP1A; G6PDX; H6PD; RGN; DERA
Glutathione metabolism
GSTT1; GPX8; GSS; GSTP2; MGST1; LAP3; GSTO1; GGT1; GSTM3; GGT6
Metabolic pathways
B3GNT5B; GLB1; INPP4B; TBXAS1; ENPP7; SMPD2; MOGS; TDO2; PLA2G7; PDHA1B
Carbon metabolism
PKM; ENO3; GOT1; ALDH6A1; ACO1; PRPS1; ALDOCA; HAO1; ME2; SUCLA2
Central carbon metabolism in cancer
HKDC1; NRAS; PFKP; G6PD; KRAS; MAPK3; TRP53; MAPK1; RET; HK1

Protein Function

G6PD has several biochemical functions, for example, NADP binding, glucose binding, glucose-6-phosphate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by G6PD itself. We selected most functions G6PD had, and list some proteins which have the same functions with G6PD. You can find most of the proteins on our site.
Function
Related Protein
Function NADP binding
Related Protein GAPDH; NOS3; CAT; GSR; NOS2; G6PDX; NOX5; POR; CRYZL1; HMGCRA
Function glucose binding
Related Protein G6PD; HK2; SLC2A3; SLC2A8; GYS1; PYGL; HKDC1; UGP2; G6PDX; HK3
Function glucose-6-phosphate dehydrogenase activity
Related Protein G6PD; H6PD; G6PDX
Function identical protein binding
Related Protein FHOD1; MDM2; VPS4B; NDC80; SP100; GBP5; FBP1; MAP1S; ALAD; CALHM1
Function protein binding
Related Protein SPRYD7; C1QTNF1; AHNAK2; RPL37A; CXXC11; PLCG1; TPM1; RTN2; LSM2; RPLP1
Function protein homodimerization activity
Related Protein PTPRE; CARM1; CCDC88A; DST; PRMT2; ACVR1; OXCT1; PML; Flt3l; ASNS

Interacting Protein

G6PD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with G6PD here. Most of them are supplied by our site. Hope this information will be useful for your research of G6PD.
SIRT2; HSPB1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ere_dna; FN1; p14340-pro_0000037966; CTR9; Snw1

G6PD Related Articles

Maiga, B; Dolo, A; et al. Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali. MALARIA JOURNAL 13:-(2014).
Liu, XD; Zhou, B; et al. BP5 regulated B cell development promoting anti-oxidant defence. AMINO ACIDS 46:209-222(2014).