galnt4
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  • Official Full Name
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
  • Background
  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5 exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist.
  • Synonyms
  • GALNT4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4); polypeptide N-acetylgalactosaminyltransferase 4; GalNAc T4; EC 2.4.1.41; GalNAc transferase 4; GalNAc-T4; GalNAcT4; GALT4_HUMAN; N-acetylgalactosaminyltransferase 4 (GalNAc-T4); Polypeptide GalNAc transferase 4; pp GaNTase 4; pp-GaNTase 4; Protein UDP acetylgalactosaminyltransferase 4; Protein-UDP acetylgalactosaminyltransferase 4; UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide
Cat.#:GALNT4-4703HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GALNT4 Protein, GST-tagged
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Cat.#:GALNT4-6187MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GALNT4 Protein
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Cat.#:GALNT4-1808RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GALNT4 Protein, His-tagged
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Cat.#:GALNT4-6036HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GALNT4 293 Cell Lysate
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Involved Pathway

GALNT4 involved in several pathways and played different roles in them. We selected most pathways GALNT4 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mucin type O-Glycan biosynthesis
GALNT1; GALNT14; GALNT10; GALNT5; GALNT9; GCNT4; ST3GAL1; GALNT11; GALNTL1; POC1BL
Metabolic pathways
ALDOAB; AHCY; HADHB; MDH1AA; CYP2B6; KHK; ALDH7A1; GPAM; P4HA1A; MIBP2

Protein Function

GALNT4 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT4 itself. We selected most functions GALNT4 had, and list some proteins which have the same functions with GALNT4. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein Fcer2a; Il2; REG3G; HBL3; KLRB1F; APCS; GALNTL6; KLRB1B; NOMO3; CHI3L1
Function metal ion binding
Related Protein HBA-X; DMRT3; FOXP4; ELP3; CYP46A1.4; MAP3K4; DMRT3A; PDLIM3A; SUZ12A; CNOT6
Function polypeptide N-acetylgalactosaminyltransferase activity
Related Protein GALNT12; GALNT3; GALNT6; GALNT9; GALNT2; GALNT14; GALNTL2; GALNTL1; GALNT13; WBSCR17

GALNT4 Related Articles

Liu, YD; Liu, WS; et al. GALNT4 Predicts Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma. JOURNAL OF UROLOGY 192:1534-1541(2014).
Erbilgin, A; Civelek, M; et al. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. JOURNAL OF LIPID RESEARCH 54:1894-1905(2013).