GATA4 Protein, GATA binding protein 4


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Official Full Name GATA binding protein 4
Background This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
Synonyms GATA4; GATA binding protein 4; ASD2; VSD1; TACHD; transcription factor GATA-4; GATA-binding factor 4;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • Myc
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA4-580H Recombinant Human GATA4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse GATA4-2441M Recombinant Mouse GATA4 Protein (1-441 aa), His-Myc-tagged E.coli His/Myc
    Human GATA4-28985TH Recombinant Human GATA4 Wheat Germ N/A
    Human GATA4-535H Recombinant Human GATA4 Protein, His-tagged E.coli His
    Human GATA4-6010HCL Recombinant Human GATA4 293 Cell Lysate HEK293 N/A
    Rat GATA4-2482R Recombinant Rat GATA4 Protein Mammalian Cell His
    Rat Gata4-536R Recombinant Rat Gata4 Protein, His-tagged E.coli His
    Chicken GATA4-5529C Recombinant Chicken GATA4 Mammalian Cell His
    Zebrafish GATA4-8835Z Recombinant Zebrafish GATA4 Mammalian Cell His

    GATA4 involved in several pathways and played different roles in them. We selected most pathways GATA4 participated on our site, such as cGMP-PKG signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway MAP2K1; RHOA; PIK3R2; CALM2; VDAC3; PIK3R3; GNAQ; NOS3; ITPR1; CALM1
    Thyroid hormone signaling pathway ITGAV; PLCG1; MTOR; TRP53; ACTG1; MED27; MAPK3; HDAC3; PIK3R1; DIO3

    GATA4 has several biochemical functions, for example, DNA binding, NFAT protein binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA4 itself. We selected most functions GATA4 had, and list some proteins which have the same functions with GATA4. You can find most of the proteins on our site.

    Function Related Protein
    NFAT protein binding GATA4; SPI1; PPARA; MAPK14; FOXP3; SFPI1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding BCL11B; PLAG1; ETV1; MEIS1; FOSL1; NKX3-2; ZKSCAN3; KCNIP3; DDIT3; MYOG
    RNA polymerase II regulatory region sequence-specific DNA binding GATA2A; ZNF79; TFAP2D; CREB3L3; RARA; ACTN4; NFKB1; ZFP39; BHLHA15; DMRT1
    RNA polymerase II transcription factor binding XBP1; KDM1A; SMAD4; HCLS1; MTA2; ZFPM2; TBX20; MKX; TOX2; GATA2
    activating transcription factor binding HDAC4; GATA4; HDAC7; ZFP516; SMAD2; ATOH8; DGKQ; RELA; MEF2D; PRDM16
    chromatin binding NOC3L; NKAP; ZFP354B; GABPA; ING5; MLL1; TADA2A; WHSC1; NKX2-5; PCGF2
    co-SMAD binding TGIF1; SMAD3; USP9X; TRIM33; GATA4; SMAD1; CITED1; SMAD2; SMAD6; FOXH1
    enhancer sequence-specific DNA binding HMGB2; ATF2; GATA4; GATA1; LDB1; KLF7B; ISL1; KLF6A; SOX11; SOX9
    protein binding SORBS2; PRR16; TH1L; RASSF5; KRT81; NFKBIE; BRCA1; MAGEA11; IL13; DAAM1
    protein kinase binding RICTOR; DNAJA3; HSPB1; CACNB3; IL31RA; SFN; FGFR1OP; CDC25A; TBC1D14; IL12RB2
    sequence-specific DNA binding SALL1A; VENT; FOXG1D; CENPB; GRHL2; ZBTB4; HOXA10B; FOXL1; PPARD; HLX1
    transcription coactivator activity PARK7; GABPA; MED20; ECD; MTF1; HCFC2; NFE2L3; SOX10; SOX17; LPIN1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding RELA; SRF; MYOG; FOXF1; OLIG2; THRA; HNF1B; SFPI1; PTH; CEBPA
    transcription factor activity, RNA polymerase II transcription factor binding MAMSTR; ZNF296; ATF4; NACC2; YAP1; SMAD4; TWIST2; ATF2; MYOCD; GATA4
    contributes_to transcription factor activity, sequence-specific DNA binding FOXH1; SMAD2; VDR; SOX19B; HNRNPAB; SMAD3; TAF6; SOX1A; NKX2-5; NKX2
    transcription factor binding HDAC11; AGTR2; PDX1; KEAP1; ARNT; MDFIC; TRERF1; NKX2; PARP1; SP1
    transcription regulatory region DNA binding ARID5B; H2AFY2; ARID5A; TP53; CARM1; ZFP639; HNF4A; FOXI1; RCOR1; CREB3L1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding SOX17; GATA5; CSRNP3; MAFG; MAFGA; SLAMF7; EAF2; NKX2; GABPA; BARHL1B
    zinc ion binding TRAF6; EP300; PDLIM5A; MT2; ISL1; JUB; DNPEP; ERI2; MORC2B; NHLRC1

    GATA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA4.


    Yamak, A; Georges, RO; et al. Novel Exons in the Tbx5 Gene Locus Generate Protein Isoforms with Distinct Expression Domains and Function. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6844-6856(2015).
    Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).

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