GBA2

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GBA2

Official Full Name glucosidase, beta (bile acid) 2
Background This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
Synonyms GBA2; glucosidase, beta (bile acid) 2; non-lysosomal glucosylceramidase; AD035; bile acid beta glucosidase; DKFZp762K054; KIAA1605; non lysosomal glucosylceramidase; MGC16895; Beta glucocerebrosidase 2; Beta glucosidase 2; Glucosylceramidase 2; NLGase; beta-glucosidase 2; beta-glucocerebrosidase 2; bile acid beta-glucosidase
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Gba2-3166M Recombinant Mouse Gba2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human GBA2-129H Recombinant Human GBA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GBA2-4767H Recombinant Human GBA2 Protein, GST-tagged Wheat Germ GST
    Human GBA2-6001HCL Recombinant Human GBA2 293 Cell Lysate HEK293 N/A
    Human GBA2-622H Recombinant Human GBA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse GBA2-6236M Recombinant Mouse GBA2 Protein Mammalian Cell His

    GBA2 involved in several pathways and played different roles in them. We selected most pathways GBA2 participated on our site, such as Other glycan degradation, Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Other glycan degradation FUCA1.1; FUCA2; MAN2B1; GBA; MAN2C1; GBA2; NEU3.3; NEU1; AGA; GLB1
    Sphingolipid metabolism SGMS2; GALCB; GLTPD1; PPAP2D; UGT8A; UGT8; PPAP2B; ENPP7; NEU3.1; CERS2A
    Metabolic pathways NDUFS1; COX4I2; PIP5K1BB; ZNRD1; GLCEB; TPH1; SDHB; NADKD1; NANS; HSD17B7

    GBA2 has several biochemical functions, for example, beta-glucosidase activity, glucosylceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA2 itself. We selected most functions GBA2 had, and list some proteins which have the same functions with GBA2. You can find most of the proteins on our site.

    Function Related Protein
    beta-glucosidase activity GBA2; GBA3
    glucosylceramidase activity GBA2; GBA

    GBA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA2.

    mtlA; ILVBL; MRPS22; LAMTOR5; PPFIA1; MRPL44; SRP68; BAG5; AFG3L2

    Burke, DG; Heales, SJ; et al. Lysosomal beta-glucosidase (GBA1) and non-lysosomal beta-glucosidase (GBA2): Potential involvement in the pathogenesis of Gaucher disease/Parkinson disease. MOLECULAR GENETICS AND METABOLISM 114:S26-S26(2015).
    Sansenya, S; Mutoh, R; et al. Expression and crystallization of a bacterial glycoside hydrolase family 116 beta-glucosidase from Thermoanaerobacterium xylanolyticum. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 71:41-44(2015).

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