GGPS1
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Official Full Name
geranylgeranyl diphosphate synthase 1
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Overview
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. -
Synonyms
GGPS1; geranylgeranyl diphosphate synthase 1; geranylgeranyl pyrophosphate synthase; GGPPS1; GGPPSase; GGPP synthase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosp;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Strep
- His|T7
- SUMO
- Myc
- DDK
- N/A
- No tag
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
GGPS1 involved in several pathways and played different roles in them. We selected most pathways GGPS1 participated on our site, such as Terpenoid backbone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Terpenoid backbone biosynthesis | MVD;PDSS2;FDPS;HMGCS1;ACAT2;HMGCS2;FNTB;PDSS1;IDI1 |
| Metabolic pathways | CYP4A10;IDH2;PIP5K1BA;PAFAH1B2;ADH2-2;B4GALT7;FBP1B;GALNT18A;UGT8A |
GGPS1 has several biochemical functions, for example, dimethylallyltranstransferase activity, farnesyltranstransferase activity, geranyltranstransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGPS1 itself. We selected most functions GGPS1 had, and list some proteins which have the same functions with GGPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dimethylallyltranstransferase activity | FDPS;GGPS1 |
| farnesyltranstransferase activity | FNTB;COX10;GGPS1 |
| geranyltranstransferase activity | FDPS;GGPS1 |
| metal ion binding | ZNF791;FKBP8;ZFP609;ATP2A2A;PLEKHM1P;ATP8A1;ARMC1;PLA2G3;FAHD2B |
| protein binding | EMILIN1;PLEK;H2-AA;SLC4A1A;RNF41;ATP6V0C;RPS2;MEPE;PTH1R |
GGPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGPS1.
ATOX1
- Q&As
- Reviews
Q&As (7)
Ask a questionGGPS1 is involved in protein prenylation, essential for the function of many proteins.
GGPS1 works in tandem with other enzymes involved in cholesterol and lipid metabolism.
Genetic mutations in GGPS1 can lead to changes in lipid metabolism and synthesis.
Altered GGPS1 activity affects the production of important lipid compounds, impacting cell function.
It plays a role in cholesterol biosynthesis by providing precursors necessary for the process.
GGPS1, Geranylgeranyl Pyrophosphate Synthase 1, is crucial for synthesizing geranylgeranyl pyrophosphate, a key intermediate in lipid metabolism.
Targeting GGPS1 offers potential treatments for disorders related to lipid metabolism.
Customer Reviews (3)
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