ghrh
Share
  • Official Full Name
  • Ghrh growth hormone releasing hormone
  • Background
  • The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the;hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate;growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of;tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of;dwarfism, while hypersecretion of the encoded protein is a cause of gigantism.
  • Synonyms
  • GHRH; growth hormone releasing hormone; somatoliberin; GRF; growth hormone-releasing factor; growth hormone-releasing hormone; GHRF;
Cat.#:GHRH-523STag:GST
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep GHRH Protein (1-44 aa), GST-tagged
+Inquiry
Cat.#:GHRH-4888HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GHRH Protein, GST-tagged
+Inquiry
Cat.#:GHRH-200HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Hormone Releasing Hormone
+Inquiry
Cat.#:GHRH-288HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Hormone Releasing Hormone
+Inquiry
Cat.#:GHRH-13251HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GHRH, His-tagged
+Inquiry
Cat.#:GHRH-132HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GHRH protein, Fc-tagged
+Inquiry
Cat.#:GHRH-661HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GHRH Protein, His/GST-tagged
+Inquiry
Cat.#:GHRH-6340MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GHRH Protein
+Inquiry
Cat.#:Ghrh-662MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ghrh Protein, His-tagged
+Inquiry
Cat.#:GHRH-2529RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GHRH Protein
+Inquiry
Cat.#:GHRH-3413CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GHRH
+Inquiry
Cat.#:GHRH-5019ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GHRH
+Inquiry
Cat.#:GHRH-37HTag:N/A
Source (Host):Species:Human
Product nameNative Human GHRH
+Inquiry
Cat.#:GHRH-704HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GHRH cell lysate
+Inquiry

Involved Pathway

GHRH involved in several pathways and played different roles in them. We selected most pathways GHRH participated on our site, such as Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHRH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class B/2 (Secretin family receptors)
ADM2A; PTHLHA; CRHR2; FZD10; SCT; EMR1; PTH; CRH; ADCYAP1R1; RCA2.1
G alpha (s) signalling events
CALCB; ADRB3; RLN3A; ADM2; GCGB; ADCYAP1; PTH2; RLN3; PTHLH; GCGA
GPCR downstream signaling
LPAR1; ADRA2C; GNA13B; DGKQ; OPN1LW1; QRFP; RGS12; TRPC6A; FGD4A; DRD3
GPCR ligand binding
NMB; PTHLHA; AGT; CCR9; OPN4.1; PENKB; DRD4; EMR1; PPY; PTHLH
Glucagon-type ligand receptors
ADCYAP1R1; ADCYAP1; GNB5B; SCT; GNB5A; GHRH; ADCYAP1B
Signal Transduction
PPEF1; EVL; RXFP2B; HECW1B; HHAT; PDK3B; CGNB; GHRB; METAP2B; SKIB
Signaling by GPCR
RGS12; RGS17; PNOC; PROKR1; ANXA1C; TAS2R13; OR10A5; OPN1SW1; ARHGEF18; RCA2.1

Protein Function

GHRH has several biochemical functions, for example, growth hormone-releasing hormone activity, growth hormone-releasing hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GHRH itself. We selected most functions GHRH had, and list some proteins which have the same functions with GHRH. You can find most of the proteins on our site.
Function
Related Protein
Function growth hormone-releasing hormone activity
Related Protein GHRL; GHRH
Function growth hormone-releasing hormone receptor binding
Related Protein GHRH

Interacting Protein

GHRH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHRH here. Most of them are supplied by our site. Hope this information will be useful for your research of GHRH.
DPP4; FAP

GHRH Related Articles

Stanley, TL; Grinspoon, SK; et al. Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies. GROWTH HORMONE & IGF RESEARCH 25:59-65(2015).
Qi, QE; Xi, QY; et al. Alteration of the miRNA expression profile in male porcine anterior pituitary cells in response to GHRH and CST and analysis of the potential roles for miRNAs in regulating GH. GROWTH HORMONE & IGF RESEARCH 25:66-74(2015).