gja8
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  • Official Full Name
  • gap junction protein, alpha 8, 50kDa
  • Background
  • This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
  • Synonyms
  • GJA8; gap junction protein, alpha 8, 50kDa; CAE, CAE1, CZP1, gap junction protein, alpha 8, 50kD (connexin 50) , gap junction protein, alpha 8, 50kDa (connexin 50); gap junction alpha-8 protein; connexin 50; CX50; connexin-50; lens fiber protein MP70; c
Cat.#:GJA8-4924HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GJA8 Protein, GST-tagged
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Cat.#:GJA8-495HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GJA8
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Cat.#:GJA8-6372MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GJA8 Protein
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Cat.#:GJA8-6555CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GJA8
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Involved Pathway

GJA8 involved in several pathways and played different roles in them. We selected most pathways GJA8 participated on our site, such as Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium Regulation in the Cardiac Cell
RGS4; ADRA1D; ADRB3; RGS6; GNB5B; KCNJ3; CX27.5; GJC1; GJB5; CASQ2
Gap junction assembly
GJB7; GJB3; GJC1; GJB2; CX27.5; GJA8; GJA5; GJD3; GJB4; CX30.3
Gap junction trafficking
GJC1; CX30.3; MYO6A; GJD3; GJA4; GJA8; GJA5; GJB5; GJB7; GJB3
Gap junction trafficking and regulation
GJB5; CX30.3; GJA4; MYO6A; GJC1; GJD3; GJB3; MYO6; DAB2; GJB7
Membrane Trafficking
SEC23IP; NSFA; SNX9B; TMED2; EXOC3; TRAPPC6B; BLOC1S1; SEC22A; TFR1B; HIP1RB
Vesicle-mediated transport
CX27.5; TERFA; MYO1C; NECAP1; CLINT1; CX30.3; FTH1A; MIA3; NAPB; TCEAL4

Protein Function

GJA8 has several biochemical functions, for example, channel activity, gap junction channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA8 itself. We selected most functions GJA8 had, and list some proteins which have the same functions with GJA8. You can find most of the proteins on our site.
Function
Related Protein
Function channel activity
Related Protein PANX1B; STEAP1; BAX; APNL; BAXA; PANX2; GJA8; P2RX6; BAXB; CHRNB1
Function gap junction channel activity
Related Protein GJA1; GJC2; CX30.3; CX52.6; PANX2; GJD3; CX23; GJB2; GJB3; GJA10

GJA8 Related Articles

Zhu, YN; Yu, H; et al. A Novel GJA8 Mutation (p.V44A) Causing Autosomal Dominant Congenital Cataract. PLOS ONE 9:-(2014).
Chen, JH; Qiu, J; et al. Rapid and cost-effective molecular diagnosis using exome sequencing of one proband with autosomal dominant congenital cataract. EYE 28:1511-1516(2014).