gnb2
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), beta polypeptide 2
  • Background
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5 UTR.
  • Synonyms
  • GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; G protein; beta 2 subunit; guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 2; signal transducing gua
Cat.#:GNB2-5054HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNB2 Protein, GST-tagged
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Cat.#:GNB2-13355HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNB2, His-tagged
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Cat.#:GNB2-7027MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNB2 Protein
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Cat.#:GNB2-2601RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNB2 Protein
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Cat.#:GNB2-2167ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GNB2
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Cat.#:GNB2-5863HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GNB2 293 Cell Lysate
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Involved Pathway

GNB2 involved in several pathways and played different roles in them. We selected most pathways GNB2 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
VEGFB; GNGT1; GNG2; PLA2G2A; GNB2; STK4; PLA2G1B; RAB5B; FGF8; NGF
Chemokine signaling pathway
CCL1; FOXO3; CCR6; PIK3R5; GNG5; RAP1B; SHC4; CCR9; CCL5; STAT1
PIK-Akt signaling pathway
LAMA4; COL6A4; GNB2; ANGPT4; KRAS; FGF19; LAMC2; IL4; IFNAR1; TLR2
Circadian entrainment
Adcy4; GNB4; GNGT2; GNAI2; GNG5; RYR2; GNG7; GNAS; CACNA1G; PLCB3
Retrograde endocannabinoid signaling
PRKCA; PLCB3; GNGT1; GNG13; GABRA3; GABRB1; GNG3; GABRE; GRM5; GRIA2
Glutamatergic synapse
SLC38A2; PLCB4; DLGAP1; ADRBK2; GRM3; PLA2G4D; GRIN2A; PRKACG; GNAQ; PPP3CC
Cholinergic synapse
GNAI2; AKT2; NRAS; ATF4; Adcy4; PIK3CD; CAMK4; PRKCA; GNB3; CHRNA6
Serotonergic synapse
PLA2G4F; HTR6; MAPK3; GNAI1; CYP2D10; CYP2C55; GNAI2; PLA2G4A; PLCB1; RAF1
GABAergic synapse
GABARAPL1; PRKCB; GABBR1; SLC12A5; SLC38A5; SRC; GABRG1; GNB3; GABRA3; GAD2
Dopaminergic synapse
GNG3; CALM4; MAOB; PPP2R2C; GNB1; KCNJ9; GNAI3; CAMK2A; PPP2R2A; SCN1A
Morphine addiction
GABRB3; GNAI1; GABRA2; GABRR3; PDE4D; PDE4B; GNB4; OPRM1; LOC100328615; GNG2
Alcoholism
HDAC4; H2AFX; HIST1H3E; H3F3C; HIST1H2BQ; HIST2H3C1; CALML5; HDAC7; GNAI2; GNG5
Pathways in cancer
ROCK2; FZD8; KIT; NFKBIA; Pdgfa&Pdgfb; TCEB2; TCF7; F2R; HHIP; FGF21

Protein Function

GNB2 has several biochemical functions, for example, GTPase activity, GTPase binding, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2 itself. We selected most functions GNB2 had, and list some proteins which have the same functions with GNB2. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activity
Related Protein RHOA; RABL2; DNAJC27; GUF1; IRGF1; GNB5; RAB18A; TUBB5; EIF5B; RRAGC
Function GTPase binding
Related Protein LCP1; HSP90AA1; EPRS; GNB1; ENO1; SH3GL1; AIMP1; GNB3; RASA1; PTPRN
Function calcium channel regulator activity
Related Protein TSPAN13; GRM2A; STIM2; CACNA2D2; TSPAN13A; TSPAN13B; STIM1A; NRXN1; CACNA2D4; PLN
Function protein binding
Related Protein MRFAP1L1; H3F3A; IGFLR1; SKA3; GOLGA8G; CPSF2; STXBP2; NOP56; FZD8; PSMG1
Function protein complex binding
Related Protein RBX1; YWHAB; LAMB3; DISC1; C8A; SHARPIN; TAPBPL; CDK5RAP2; ATP6V1B1; PDZK1
Function signal transducer activity
Related Protein ECM1; VOPP1; TAAR2; MAGI2; EDNRAB; PLCXD3; TSPAN6; GNGT1; MTNR1C; GPR158

Interacting Protein

GNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2.
Cdk1; Cbx1; Cep76; IKBKE; USP50; Trim69; Haus4; Haus1; MAP3K3; Mau2; TRAF6; RIPK3; CAPNS1; TFAP2A; PDHB; RCC1; ANXA7; GADD45A; CDKN1A; STAT5A

GNB2 Related Articles

Xing, T; Higgins, VJ; et al. Identification of G proteins mediating fungal elicitor-induced dephosphorylation of host plasma membrane H+-ATPase. JOURNAL OF EXPERIMENTAL BOTANY 48:229-237(1997).
Joshi, S; Abebe, W; et al. G-proteins in guinea pig airway smooth muscle: Identification and functional involvement. PHARMACOLOGICAL RESEARCH 33:195-202(1996).
LIU, JJ; MCLENNAN, AG; et al. PURIFICATION AND PROPERTIES OF GTP-GTP GUANYLYLTRANSFERASE FROM ENCYSTED EMBRYOS OF THE BRINE SHRIMP ARTEMIA. JOURNAL OF BIOLOGICAL CHEMISTRY 269:11787-11794(1994).