grik2
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  • Official Full Name
  • glutamate receptor, ionotropic, kainate 2
  • Background
  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
  • Synonyms
  • GRIK2; glutamate receptor, ionotropic, kainate 2; GLUR6; glutamate receptor, ionotropic kainate 2; MRT6; gluR-6; bA487F5.1; OTTHUMP00000017949; OTTHUMP00000017950; OTTHUMP00000017951; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate recep; EAA4; GLR6; GLUK6
Cat.#:GRIK2-5337HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRIK2 Protein, GST-tagged
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Cat.#:GRIK2-2118HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRIK2 protein, His & T7-tagged
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Cat.#:GRIK2-675HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human GRIK2 Protein, Fc-tagged
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Cat.#:GRIK2-2696RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRIK2 Protein
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Cat.#:GRIK2-5747HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRIK2 293 Cell Lysate
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Involved Pathway

GRIK2 involved in several pathways and played different roles in them. We selected most pathways GRIK2 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
EDNRAA; TAAR7A; ADORA2AA; SSTR5; CHRNA4; S1PR3; GLP1R; PLG; GABRB1; TAAR14E
Glutamatergic synapse
SHANK2; GRIN3B; GNG10; GRIA4; SLC38A1; PRKCA; MAPK1; SLC1A6; GNG11; PLA2G4A

Protein Function

GRIK2 has several biochemical functions, for example, PDZ domain binding, extracellular-glutamate-gated ion channel activity, kainate selective glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK2 itself. We selected most functions GRIK2 had, and list some proteins which have the same functions with GRIK2. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein PTENA; SLC26A6; ACOX1; PARK2; DOCK4; LPAR2; DLC; SNTB1; LRP2; GRM7
Function extracellular-glutamate-gated ion channel activity
Related Protein GRIA3A; GRIK4; GRID1; GRIN2A; GRIA4B; GRIN2BB; GRIK5; GRIN2B; GRIA1A; GRIA4A
Function kainate selective glutamate receptor activity
Related Protein GRIK5; GRIK3; GRIK4; GRIK2; GRIK1
Function protein homodimerization activity
Related Protein SLC14A2; TIMELESS; ADAM10; DDX1; PDCD6; SPATA24; AGXT; HHEX; HEXB; BCL2
Function ubiquitin conjugating enzyme binding
Related Protein RNF144AA; RNF144A; DCUN1D1; ZMYM2; RNF19B; DCUN1D2B; SIAH2; TOLLIP; ANKIB1A; ARIH1L
Function ubiquitin protein ligase binding
Related Protein ANKRD32; TSG101; POLR2A; DIO2; AKTIP; MAP1LC3C; NGFR; CUL1; RRAGA; UBE2S

Interacting Protein

GRIK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK2.
TRIM25; CALCOCO1

GRIK2 Related Articles

Shen, W; Hanley-Bowdoin, L; et al. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1-and mammalian AMPK-activating kinases. PLANT PHYSIOLOGY 142:1642-1655(2006).
PASCHEN, W; BLACKSTONE, CD; et al. HUMAN GLUR6 KAINATE RECEPTOR (GRIK2) - MOLECULAR-CLONING, EXPRESSION, POLYMORPHISM, AND CHROMOSOMAL ASSIGNMENT. GENOMICS 20:435-440(1994).