GRIK2

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GRIK2

Official Full Name glutamate receptor, ionotropic, kainate 2
Background Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
Synonyms GRIK2; glutamate receptor, ionotropic, kainate 2; GLUR6; glutamate receptor, ionotropic kainate 2; MRT6; gluR-6; bA487F5.1; OTTHUMP00000017949; OTTHUMP00000017950; OTTHUMP00000017951; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate recep; EAA4; GLR6; GLUK6
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRIK2-2118H Recombinant Human GRIK2 protein, His & T7-tagged E.coli His/T7
    Human GRIK2-5337H Recombinant Human GRIK2 Protein, GST-tagged Wheat Germ GST
    Human GRIK2-5747HCL Recombinant Human GRIK2 293 Cell Lysate HEK293 N/A
    Human GRIK2-675H Recombinant Human GRIK2 Protein, Fc-tagged HEK293 Fc
    Rat GRIK2-2696R Recombinant Rat GRIK2 Protein Mammalian Cell His

    GRIK2 involved in several pathways and played different roles in them. We selected most pathways GRIK2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction AVPR2; P2RX3A; TAAR10C; F2RL1; EDNRBA; LEP; GPR50; RXFP3; SSTR1; TAAR6
    Glutamatergic synapse SHANK1; TRPC1; GNG12; GNAI1; PRKACA; SLC1A7; GNG13; GRIN3A; PLCB4; GLUL

    GRIK2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK2 itself. We selected most functions GRIK2 had, and list some proteins which have the same functions with GRIK2. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding GRIK2; BAIAP2; ARHGAP29; LIN7B; USHBP1; CXXC4; Apba1; SNTA1; CCDC88C; GRID2
    extracellular-glutamate-gated ion channel activity GRIA3; KBP; GRIA2A; GRIN3A; GRIK4; GRID1; GRIA4B; GRIA4A; GRIK5; GRIN2A
    kainate selective glutamate receptor activity GRIK3; GRIK1; GRIK4; GRIK5; GRIK2
    protein homodimerization activity INHBB; RELA; PGCP; CORO1A; GHR; DMRTC2; DNTTIP1; LHPP; DLK2; CEACAM1
    ubiquitin conjugating enzyme binding RNF180; TCHP; TRIM72; MARCH6; GRIK2; RNF144B; ANKIB1; DCUN1D4; RNF40; PPARA
    ubiquitin protein ligase binding BCL2; SQSTM1; ERLIN2; UBE2K; RB1; RELA; Fzd4; BAG6; HERC2; UCHL1

    GRIK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK2.

    TRIM25; CALCOCO1

    Shen, W; Hanley-Bowdoin, L; et al. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1-and mammalian AMPK-activating kinases. PLANT PHYSIOLOGY 142:1642-1655(2006).
    PASCHEN, W; BLACKSTONE, CD; et al. HUMAN GLUR6 KAINATE RECEPTOR (GRIK2) - MOLECULAR-CLONING, EXPRESSION, POLYMORPHISM, AND CHROMOSOMAL ASSIGNMENT. GENOMICS 20:435-440(1994).

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