GRK6
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Official Full Name
G protein-coupled receptor kinase 6
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Overview
G protein-coupled receptor kinase 6 (GRK6) is a widely expressed member of the AGC Ser/Thr protein kinase family and is comprised of an AGC-kinase C-terminal domain, a protein kinase domain, and a RGS domain. GRK6, like other GRKs, possesses unique activity against activated G protein-coupled receptors, which serves to regulate activation-dependent desensitization of the GPCR active forms. Studies have shown a critical role for GRK6 in the regulation of lymphocyte CXCR4 activity. -
Synonyms
GRK6; G protein-coupled receptor kinase 6; GPRK6; FLJ32135;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Tag
- free
- Involved Pathway
- Protein Function
- Interacting Protein
- GRK6 Related Articles
- GRK6 Related Signal Pathway
GRK6 involved in several pathways and played different roles in them. We selected most pathways GRK6 participated on our site, such as Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GRK1;RAF1;CCL25;CCL6;CCL16;LOC100033925;ROCK1;RAP1A;CXCL13 |
| Endocytosis | MET;MVB12BB;IGF1RB;TFRC;STAMBPA;RAB5C;ARFGAP1;KIF5C;KIF5A |
GRK6 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK6 itself. We selected most functions GRK6 had, and list some proteins which have the same functions with GRK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCC11;ATP8B3;NLRP12;PIF1;TTLL6;RUNX2A;ATAD1B;TIMM44;ROS1 |
| G-protein coupled receptor kinase activity | GRK1B;ADRBK2;RLN1;GRK1A;GRK1;GRK6;GRK7;GRK7B;GRK4 |
| beta-adrenergic receptor kinase activity | GRK6;ADRBK2;GRK5;ADRBK1 |
| protein binding | COG1;CRYAA;MTA1;COMT;MRM1;FERMT2;RNF146;FATE1;OXR1 |
GRK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK6.
ROM1; HSP90AB1; PRSS23; ITGA5
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