grk6
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  • Official Full Name
  • G protein-coupled receptor kinase 6
  • Background
  • G protein-coupled receptor kinase 6 (GRK6) is a widely expressed member of the AGC Ser/Thr protein kinase family and is comprised of an AGC-kinase C-terminal domain, a protein kinase domain, and a RGS domain. GRK6, like other GRKs, possesses unique activity against activated G protein-coupled receptors, which serves to regulate activation-dependent desensitization of the GPCR active forms. Studies have shown a critical role for GRK6 in the regulation of lymphocyte CXCR4 activity.
  • Synonyms
  • GRK6; G protein-coupled receptor kinase 6; GPRK6; FLJ32135
Cat.#:GRK6-2360HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GRK6 Protein, MYC/DDK-tagged
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Cat.#:GRK6-393HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRK6 Protein, His-tagged
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Cat.#:GRK6-5358HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRK6 Protein, GST-tagged
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Cat.#:GRK6-13542HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRK6, GST-tagged
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Cat.#:GRK6-974HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GRK6, His & GST tagged
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Cat.#:GRK6-7282MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRK6 Protein
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Cat.#:GRK6-1020HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human G Protein-Coupled Receptor Kinase 6, GST-tagged
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Cat.#:GRK6-1233HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human G Protein-Coupled Receptor Kinase 6, GST-tagged
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Cat.#:GRK6-622HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GRK6 cell lysate
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Involved Pathway

GRK6 involved in several pathways and played different roles in them. We selected most pathways GRK6 participated on our site, such as Chemokine signaling pathway, Endocytosis, Morphine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
CCL3L1; NCF1; CXCL8; GNGT1; PIK3R2; IL-8; NRAS; CCL21; GNGT2; CCL4L2
Endocytosis
ARFGAP3; SH3GL1; ARPC1B; HLA-E; ASAP1A; EHD1A; CSF1RA; HGS; CYTH4B; PIP5K1A
Morphine addiction
GNG10; PDE4A; PDE7A; PDE4B; GNG13; GABRA6; PDE11A; GABRB3; GNG4; GABBR2

Protein Function

GRK6 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK6 itself. We selected most functions GRK6 had, and list some proteins which have the same functions with GRK6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein BMPR1AA; ADCY7; CNTN1B; ERBB3A; UBE2S; PIF1; ITGB1BP3; PI4K2A; RUVBL1; NOLC1
Function G-protein coupled receptor kinase activity
Related Protein GRK7A; GRK7; GRK1; GRK7B; GRK1A; RLN1; GRK1B; GRK5; ADRBK2; GRK6
Function beta-adrenergic receptor kinase activity
Related Protein GRK6; ADRBK2; ADRBK1; GRK5
Function protein binding
Related Protein PCMT1; LAMTOR3; RARA; LRRC26; HIST2H4; SNAP91; MRPL53; TEKT4; CD300LH; MIPOL1

Interacting Protein

GRK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK6.
ROM1; HSP90AB1; PRSS23; ITGA5

GRK6 Related Articles

Zhou, Y; Huang, XD; et al. Decreased Expression and Role of GRK6 in Spinal Cord of Rats After Chronic Constriction Injury. NEUROCHEMICAL RESEARCH 38:2168-2179(2013).
Nedi, T; White, PJ; et al. Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract. BIOCHEMICAL PHARMACOLOGY 81:123-133(2011).