Recombinant Mouse Grk6 Protein, Myc/DDK-tagged

• Cat.No.: Grk6-3312M
• Product Overview: Purified recombinant protein of mouse full-length G protein-coupled receptor kinase 6 (Grk6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
• Molecular Mass: 67.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Grk6 G protein-coupled receptor kinase 6 [ Mus musculus (house mouse) ]
• Official Symbol: Grk6
• Synonyms: GRK6; G protein-coupled receptor kinase 6; g protein-coupled receptor kinase GRK6; Gprk6
• Gene ID: 26385
• mRNA Refseq: NM_001112711
• Protein Refseq: NP_001106182
• UniProt ID: O70293