grm3
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  • Official Full Name
  • glutamate receptor, metabotropic 3
  • Background
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
  • Synonyms
  • Grm3; glutamate receptor, metabotropic 3; mGluR3; metabotropic glutamate receptor 3; Gprc1c, Mglur3
Cat.#:GRM3-5366HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRM3 Protein, GST-tagged
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Cat.#:GRM3-1941HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRM3 protein, His & GST-tagged
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Cat.#:GRM3-29609THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GRM3
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Cat.#:GRM3-29610THTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRM3 protein
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Cat.#:GRM3-7286MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRM3 Protein
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Cat.#:GRM3-2715RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRM3 Protein
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Cat.#:GRM3-6856ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GRM3
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Cat.#:GRM3-5735HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRM3 293 Cell Lysate
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Cat.#:CSC-RG0304Tag:
Source (Host):Species:Human
Product nameHuman GRM3-FLAG Stable Cell Line-HEK293T Galphaqi5
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Cat.#:CSC-RG0454Tag:
Source (Host):Species:Human
Product nameHuman GRM3-FLAG Stable Cell Line-HEK293T Galphaqi5
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Cat.#:CSC-RG0557Tag:
Source (Host):Species:Human
Product nameHuman GRM3/Gi Stable Cell Line-CHO
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Involved Pathway

GRM3 involved in several pathways and played different roles in them. We selected most pathways GRM3 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phospholipase D signaling pathway
MS4A2; DGKZ; GRM6; PTK2B; TSC2; RRAS; CXCR2; PIK3R3; Adcy4; KITLG
Neuroactive ligand-receptor interaction
P2RX8; GABRB2; BRS3; P2RX4A; P2RY14; HRH1; GRIA1; TAAR14D; TAAR13E; OPRD1A
Glutamatergic synapse
SLC17A7; PLCB2; GRM8; Adcy4; PRKACA; MAPK3; SLC17A6; SHANK2; GRIN3A; GNB2
Cocaine addiction
GRIN1; GRIN3A; CREB3L1; DRD1A; GRIN2D; SLC18A1; CREB3L2; CDK5; PRKACA; GRM3

Protein Function

GRM3 has several biochemical functions, for example, G-protein coupled receptor activity, calcium channel regulator activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM3 itself. We selected most functions GRM3 had, and list some proteins which have the same functions with GRM3. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein TAAR14E; OLFR8; MRGPRA8; OLFR476; TAS2R137; MRGPRB2; CXCR1; NPFFR1L2; OR4N4; GRM6
Function calcium channel regulator activity
Related Protein SRI; TSPAN13A; NRXN1; NRXN2; CAV3; HPCAL4; SGK2B; CACNA2D1A; SGK2A; GRM6A
Function glutamate receptor activity
Related Protein GRM8; GRM6; GRM2; GRM5; GRIK5; GRM4; GRM7; GRIA1; GRIK3; GRID2
Function group II metabotropic glutamate receptor activity
Related Protein GRM2A; GRM2; GRM3
Function NOT group III metabotropic glutamate receptor activity
Related Protein GRM3

GRM3 Related Gene Family

GPCRs