| Description : |
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Form : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
| Molecular Mass : |
98.9 kDa |
| AA Sequence : |
MKMLTRLQVLTLALFSKGFLLSLGD HNFLRREIKIEGDLVLGGLFPINEK GTGTEECGRINEDRGIQRLEAMLFA IDEINKDDYLLPGVKLGVHILDTCS RDTYALEQSLEFVRASLTKVDEAEY MCPDGSYAIQENIPLLIAGVIGGSY SSVSIQVANLLRLFQIPQISYASTS AKLSDKSRYDYFARTVPPDFYQAKA MAEILRFFNWTYVSTVASEGDYGET GIEAFEQEARLRNICIATAEKVGRS NIRKSYDSVIRELLQKPNARVVVLF MRSDDSRELIAAASRANASFTWVAS DGWGAQESIIKGSEHVAYGAITLEL ASQPVRQFDRYFQSLNPYNNHRNPW FRDFWEQKFQCSLQNKRNHRRVCDK HLAIDSSNYEQESKIMFVVNAVYAM AHALHKMQRTLCPNTTKLCDAMKIL DGKKLYKDYLLKINFTAPFNPNKDA DSIVKFDTFGDGMGRYNVFNFQNVG GKYSYLKVGHWAETLSLDVNSIHWS RNSVPTSQCSDPCAPNEMKNMQPGD VCCWICIPCEPYEYLADEFTCMDCG SGQWPTADLTGCYDLPEDYIRWEDA WAIGPVTIACLGFMCTCMVVTVFIK HNNTPLVKASGRELCYILLFGVGLS YCMTFFFIAKPSPVICALRRLGLGS SFAICYSALLTKTNCIARIFDGVKN GAQRPKFISPSSQVFICLGLILVQI VMVSVWLILEAPGTRRYTLAEKRET VILKCNVKDSSMLISLTYDVILVIL CTVYAFKTRKCPENFNEAKFIGFTM YTTCIIWLAFLPIFYVTSSDYRVQT TTMCISVSLSGFVVLGCLFAPKVHI ILFQPQKNVVTHRLHLNRFSVSGTG TTYSQSSASTYVPTVCNGREVLDST TSSL |
| Applications : |
Antibody Production;Functional Study: Recommended usage only, not validated yet.Compound Screening: Recommended usage only, not validated yet. |
| Notes : |
Best use within three months from the date of receipt of this protein. Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
