gsta2
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  • Official Full Name
  • glutathione S-transferase alpha 2
  • Background
  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
  • Synonyms
  • GSTA2; glutathione S-transferase alpha 2; glutathione S transferase A2 , GST2; glutathione S-transferase A2; EC 2.5.1.18; Glutathione S transferase 2; Glutathione S transferase A2; Glutathione S-alkyltransferase A2; Glutathione S-aralkyltransferase A2; Glutathione S-aryltransferase A2; Glutathione S-transferase GT41A; Glutathione S-transferase Ya-2; Glutathione S-transferase, alpha 2 (Yc2); GST 1b-1b; GST A2-2; GST class alpha member 2; GST gamma; GST Ya2; GST, class alpha, 2; GST2; Gst2-2; GSTA2 2; GSTA2-2; Gstc-2; Gstc2; GTA2; GTH2; HA subunit 2; Liver GST2; MGC10525; OTTHUMP00000017883; S-(hydroxyalkyl)glutathione lyase A2; GST-gamma; GST HA subunit 2; GST class-alpha member 2
Cat.#:GSTA2-4410HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSTA2 Protein, GST-tagged
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Cat.#:GSTA2-13570HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTA2, GST-tagged
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Cat.#:GSTA2-2015HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTA2 protein, His-tagged
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Cat.#:GSTA2-27546THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GSTA2
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Cat.#:Gsta2-2016MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gsta2 protein, His & T7-tagged
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Cat.#:GSTA2-7325MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GSTA2 Protein
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Cat.#:GSTA2-1987RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GSTA2 Protein, His-tagged
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Cat.#:GSTA2-5718HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GSTA2 293 Cell Lysate
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Involved Pathway

GSTA2 involved in several pathways and played different roles in them. We selected most pathways GSTA2 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GSTM6; GPX2; GPX8; GPX4A; GSTT1B; GGCTA; GSTP1; GPX4; GPX5; MGST1.1
Metabolism of xenobiotics by cytochrome P
MGST1.1; UGT1A7; MGST1; UGT1A9; GSTM5; UGT2B7; GSTO1; GSTM6; ALDH3B1; CBR1
Drug metabolism - cytochrome P
AOX4; AOX3L1; GSTA1; UGT1A6B; GSTM3; GSTT2; MGST1; UGT5G1; UGT2A1; GSTM5
Chemical carcinogenesis
GSTM7; GSTT2; GSTA2; UGT1A1; CYP2C70; SULT1A3; GSTT2B; UGT1A3; MGST1; UGT2A3

Protein Function

GSTA2 has several biochemical functions, for example, glutathione transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTA2 itself. We selected most functions GSTA2 had, and list some proteins which have the same functions with GSTA2. You can find most of the proteins on our site.
Function
Related Protein
Function glutathione transferase activity
Related Protein GDAP1L1; GSTA1; GSTK1; GSTM1; EEF1E1; GSTM5; GSTM6; LTC4S; GSTM4; GDAP1
Function protein binding
Related Protein MAPK6; C2orf50; SELPLG; GPSM2; COBRA1; KCNJ9; PIN4; DKC1; LRP4; PSENEN

Interacting Protein

GSTA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTA2.
GSTA4

GSTA2 Related Articles

Fujimura, H; Murakami, N; et al. The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 64:527-533(2012).
Nishimura, J; Dewa, Y; et al. Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats. ARCHIVES OF TOXICOLOGY 82:641-654(2008).