GSTM4

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GSTM4

Official Full Name glutathione S-transferase mu 4
Background Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
Synonyms GSTM4; glutathione S-transferase mu 4; glutathione S transferase M4; Glutathione S transferase Mu 4; GST class mu 4; GST class-mu 4; GST-Mu2; GSTM4 4; GSTM4-4; GSTM4_HUMAN; GTM4; GTS Mu2; MGC131945; MGC9247; GTS-Mu2; OTTHUMP00000013356; OTTHUMP00000013358; glutathione S-transferase M4; glutathione S-aryltransferase M4; glutathione S-alkyltransferase M4; glutathione S-aralkyltransferase M4; S-(hydroxyalkyl)glutath
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Gstm4-1069M Recombinant Mouse Gstm4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human GSTM4-1106H Recombinant Human GSTM4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GSTM4-13577H Recombinant Human GSTM4, GST-tagged E.coli GST
    Human GSTM4-1692H Recombinant Human Glutathione S-Transferase Mu 4, His-tagged Human His
    Human GSTM4-27545TH Recombinant Human GSTM4, His-tagged E.coli His
    Human GSTM4-27770TH Recombinant Human GSTM4, His-tagged E.coli His
    Human GSTM4-4420H Recombinant Human GSTM4 Protein, GST-tagged Wheat Germ GST
    Human GSTM4-5711HCL Recombinant Human GSTM4 293 Cell Lysate HEK293 N/A
    Human GSTM4-780H Recombinant Human Glutathione S-transferase Mu 4, His-tagged E.coli His
    Rat Gstm4-652R Recombinant Rat Gstm4 protein, His & T7-tagged E.coli His/T7
    Cynomolgus Monkey GSTM4-577C Recombinant Cynomolgus GSTM4 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque GSTM4-1994R Recombinant Rhesus monkey GSTM4 Protein, His-tagged Mammalian Cell His

    GSTM4 involved in several pathways and played different roles in them. We selected most pathways GSTM4 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutathione metabolism GSS; MGST3; OPLAH; GSTM6; MGST1.1; GGCT; GSTT2B; GSTK1; GGT5; GSTA5
    Metabolism of xenobiotics by cytochrome P EPHX1; UGT2B15; MGST1; GSTT2; MGST1.2; GSTT2B; UGT2A3; MGST2; GSTA2; UGT1A7C
    Drug metabolism - cytochrome P UGT1A6A; AOX3L1; FMO2; UGT2A1; GSTA1; UGT1A4; GSTO1; MGST1.1; GSTM7; UGT1A7C
    Chemical carcinogenesis UGT1A7C; CHRNA7; CYP3A5; SULT1A3; GSTM1; ADH5; MGST1; UGT1A2; ADH1; Nat3

    GSTM4 has several biochemical functions, for example, enzyme binding, glutathione binding, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM4 itself. We selected most functions GSTM4 had, and list some proteins which have the same functions with GSTM4. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding LYN; ARPC4; NOP14; UGT1A1; CRB2; APBA3; PAWR; NKX2-1; TRAF2; USP22
    glutathione binding MGST1; GPX1; PTGES; LTC4S; GSS; GSTM1; LANCL1; GSTM4; PTGESL; GSTM2
    glutathione transferase activity GSTM1; GSTAL; GSTT2B; GSTM7; EEF1G; GSTT1B; GSTT4; GSTM2; GSTM5; LTC4S
    protein binding SUV39H2; TAOK3; PLEK; H3F3C; BCL2L14; ITGA5; C22orf23; F8; KIAA1191; IPO5
    protein homodimerization activity RNF40; GPD1C; MYH7; DEM1; KCNK3; SLC22A1; CBX5; SYT10; BLOC1S6; ABCG1

    GSTM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM4.

    GSTM3; TP53; APLP1; TLE1; ZBTB16; UNC119; RIF1; NELFCD; IGSF21; MED31

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