gtf2b
Share
  • Official Full Name
  • general transcription factor IIB
  • Background
  • This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
  • Synonyms
  • GTF2B; general transcription factor IIB; TF2B; TFIIB; transcription initiation factor IIB; S300-II; general transcription factor TFIIB; RNA polymerase II transcription factor IIB;
Cat.#:GTF2B-4440HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GTF2B Protein, GST-tagged
+Inquiry
Cat.#:GTF2B-1176HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human General Transcription Factor IIB
+Inquiry
Cat.#:GTF2B-1177HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human General Transcription Factor IIB, GST-tagged
+Inquiry
Cat.#:GTF2B-13590HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GTF2B, GST-tagged
+Inquiry
Cat.#:GTF2B-1831HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human General Transcription Factor IIB, His tagged
+Inquiry
Cat.#:GTF2B-30661THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GTF2B, His-tagged
+Inquiry
Cat.#:GTF2B-30662THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GTF2B
+Inquiry
Cat.#:GTF2B-5018HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human General Transcription Factor II, His-tagged
+Inquiry
Cat.#:GTF2B-7353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GTF2B Protein
+Inquiry
Cat.#:GTF2B-2741RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GTF2B Protein
+Inquiry
Cat.#:GTF2B-2002RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GTF2B Protein, His-tagged
+Inquiry
Cat.#:GTF2B-10094ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GTF2B
+Inquiry
Cat.#:GTF2B-5703HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GTF2B 293 Cell Lysate
+Inquiry

Involved Pathway

GTF2B involved in several pathways and played different roles in them. We selected most pathways GTF2B participated on our site, such as Basal transcription factors, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
TAF6; MNAT1; TAF12; GTF2E2; TAF8; TAF7; TAF4B; TBPL1; GTF2H2C_2; ERCC2
Epstein-Barr virus infection
HLA-DQB1; CDK1; ENTPD3; MAPK10; POLR2A; POLR2C; TP53; IKBKG; HLA-DRB4; RBPJ
Viral carcinogenesis
HIST1H2BB; GTF2B; CASP8; MAD1L1; HIST1H2BP; HIST1H2BI; TRAF5; YWHAG; HLA-E; DNAJA3

Protein Function

GTF2B has several biochemical functions, for example, core promoter binding, protein binding, thyroid hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2B itself. We selected most functions GTF2B had, and list some proteins which have the same functions with GTF2B. You can find most of the proteins on our site.
Function
Related Protein
Function core promoter binding
Related Protein SPI1; CLOCK; MYOD1; NONO; E2F2; PYDC3; MTF1; NPAS2; E2F1; RB1
Function protein binding
Related Protein MUTED; RNF10; DMAP1; TCEB3; ATF1; MAPK8IP3; STAT5B; ASNS; PRPF4B; BCL2L1
Function thyroid hormone receptor binding
Related Protein NSD1; THRAP3; MED12; NCOR1; OASL; MED24; NCOA3; NUP62; TRIP6; MED1
Function transcription factor binding
Related Protein FOXO4; SOX10; DDIT3; NLRP3; PDX1; MAPK1; STAT3; NIF3L1; CTBP1; EGR1
Function zinc ion binding
Related Protein ZDHHC11; TRIM42; SHRPRBCK1R; RBM20; DTX1; RNF148; RNF5; ARIH1; ZRANB2; BMI1

Interacting Protein

GTF2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2B here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2B.
E2; E2; DRAP1; TNIP1; lt_sv40; NR2F1; Vdr; GTF2F2

GTF2B Related Articles

Sayed, D; Yang, Z; et al. In Vivo Targeting Of GTF2B Selectively Inhibits Transcription Of Cardiomyopathy-related Genes And Partially Blunts Development Of Cardiac Hypertrophy. CIRCULATION RESEARCH 113:-(2013).
Faresse, NJ; Canella, D; et al. Genomic Study of RNA Polymerase II and III SNAP(c)-Bound Promoters Reveals a Gene Transcribed by Both Enzymes and a Broad Use of Common Activators. PLOS GENETICS 8:-(2012).