gys2
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  • Official Full Name
  • glycogen synthase 2 (liver)
  • Background
  • The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content.
  • Synonyms
  • GYS2; glycogen synthase 2 (liver); glycogen [starch] synthase, liver; Glycogen starch synthase liver; EC 2.4.1.11; Glycogen synthase 2 liver
Cat.#:GYS2-4513HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GYS2 Protein, GST-tagged
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Cat.#:GYS2-13635HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GYS2, His-tagged
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Cat.#:GYS2-7408MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GYS2 Protein
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Cat.#:GYS2-2769RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GYS2 Protein
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Cat.#:GYS2-2672ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GYS2
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Cat.#:GYS2-5669HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GYS2 293 Cell Lysate
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Involved Pathway

GYS2 involved in several pathways and played different roles in them. We selected most pathways GYS2 participated on our site, such as Starch and sucrose metabolism, PIK-Akt signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GYS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Starch and sucrose metabolism
GUSB; GYS2; PGM2; UGP2B; AMY2A4; UGT2A2; UGT2A1; AMY2A; AMY1B; GYS1
PIK-Akt signaling pathway
RHEB; IFNA21; MLST8; CREB5; PIK3CD; FGF2; IKBKG; COL6A4; EPOR; FGFR2
AMPK signaling pathway
PPP2R1A; ADRa1A; PIK3R5; CFTR; CPT1C; PPP2R3C; PFKFB3; SCD5; STK11; PPP2R5E
Insulin signaling pathway
PPARGC1A; BADB; PRKAR2AB; MTOR; MAPK3; PRKACBA; MKNK2A; PRKAR2B; PRKAR2AA; RHOQ
Glucagon signaling pathway
LDHAL6B; PGAM1; PPP3CA; PDHA2; PRKAG2; PRKAG3; SLC2A1; G6PC; ACACA; G6PC2
Insulin resistance
CD36; CREB3L3L; TRIB3; MLXIPL; FOXO1; PPP1CA; OGT.1; NR1H2; GYS2; FOXO1B

Protein Function

GYS2 has several biochemical functions, for example, glycogen (starch) synthase activity, glycogen synthase activity, transferring glucose-1-phosphate, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GYS2 itself. We selected most functions GYS2 had, and list some proteins which have the same functions with GYS2. You can find most of the proteins on our site.
Function
Related Protein
Function glycogen (starch) synthase activity
Related Protein GYS1; GYS2
Function glycogen synthase activity, transferring glucose-1-phosphate
Related Protein GYS1; GYS2
Function protein homodimerization activity
Related Protein WRN; S100A16; GNB2L1; STK4; LRP6; LRP4; CSF1; CPOX; DARS2; NDP

Interacting Protein

GYS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GYS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GYS2.
GYG2; TNFRSF1A; GABARAP

GYS2 Related Articles

Lau, MY; Han, H; et al. Association of cyclin D and estrogen receptor alpha 36 with hepatocellular adenomas of female mice under chronic endoplasmic reticulum stress. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 28:576-583(2013).
Vadrot, N; Ghanem, S; et al. Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3 beta and p53 in Response to Tumor Necrosis Factor alpha. PLOS ONE 7:-(2012).