gzmh
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  • Official Full Name
  • granzyme H (cathepsin G-like 2, protein h-CCPX)
  • Background
  • The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine;proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like;activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3 and;P4 positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the;cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in;pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein;isoforms.
  • Synonyms
  • GZMH; granzyme H (cathepsin G-like 2, protein h-CCPX); CTSGL2; granzyme H; CCP X; CGL 2; CSP C; CTLA1; Cathepsin G like 2; CGL2; Cytotoxic serine protease C; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T lymphocyte proteinase; EC 3.4.21.-; Protein h CCPX; OTTHUMP00000178753; OTTHUMP00000245745; cathepsin G-like 2; cytotoxin serine protease-C; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte-associated serine esterase 1; CCP-X; CGL-2; CSP-C
Cat.#:GZMH-4521HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GZMH Protein, GST-tagged
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Cat.#:GZMH-1856HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GZMH protein, His & T7-tagged
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Cat.#:GZMH-297HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GZMH, His tagged
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Cat.#:GZMH-2943HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human GZMH cell lysate
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Involved Pathway

GZMH involved in several pathways and played different roles in them. We selected most pathways GZMH participated on our site, such as Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of Angiotensinogen to Angiotensins
ACE; CPB1; GZMH; ATP6AP2; CTSG; CMA1; CPB2; CPA3
Metabolism of proteins
TBCC; TUBA3D; DDOST; YIF1A; GATA6; C19orf10; TBCB; YY2; FXC1; PFDN1
Peptide hormone metabolism
BCHE; MBOAT4; GRP; SLC30A8; SLC38A8; EXOC8; CPE; CPA3; GPR119; SPCS3
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
IGFBP4; IGFBP6A; IGFBP2A; IGFBP2B; PAPPA2; IGFBP5; GZMH; IGF2B; IGFBP2; KLK13

Protein Function

GZMH has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMH itself. We selected most functions GZMH had, and list some proteins which have the same functions with GZMH. You can find most of the proteins on our site.
Function
Related Protein
Function serine-type endopeptidase activity
Related Protein HPR; EGFBP2; CFD; KLK11; GZMC; MCPT8; HTRA2; PROCA; ELA3L; TMPRSS11E

Interacting Protein

GZMH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMH here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMH.
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