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GZMH

Official Full Name

granzyme H (cathepsin G-like 2, protein h-CCPX)
Overview

The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine;proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like;activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3 and;P4 positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the;cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in;pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein;isoforms.
Synonyms

GZMH; granzyme H (cathepsin G-like 2, protein h-CCPX); CTSGL2; granzyme H; CCP X; CGL 2; CSP C; CTLA1; Cathepsin G like 2; CGL2; Cytotoxic serine protease C; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T lymphocyte proteinase; EC 3.4.21.-; Protein h CCPX; OTTHUMP00000178753; OTTHUMP00000245745; cathepsin G-like 2; cytotoxin serine protease-C; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte-associated serine esterase 1; CCP-X; CGL-2; CSP-C;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
Human Cell
In Vitro Cell Free System
NS0
Wheat Germ

Tag

C
His
GST
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GZMH-01HFL	Recombinant Full Length Human GZMH Protein, C-His-tagged	NS0	C-His	Glu19-Leu246	Inquiry
Human	GZMH-4521H	Recombinant Human GZMH Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GZMH-297H	Recombinant Human GZMH protein, His-tagged	HEK293	His	Met1-Leu246	$623 / 10 µg
Human	GZMH-2943HCL	Recombinant Human GZMH cell lysate	Human Cell	N/A		Inquiry
Human	GZMH-1856H	Recombinant Human GZMH protein, His & T7-tagged	E.coli	His/T7	Glu19~Leu246 (Accession # P20718)	Inquiry
Human	GZMH-3646H	Recombinant Human GZMH Protein (Glu19-Leu246), N-His tagged	E.coli	N-His	Glu19-Leu246	Inquiry
Human	GZMH-3390HF	Recombinant Full Length Human GZMH Protein, GST-tagged	In Vitro Cell Free System	GST	246 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GZMH Related Research Area

GZMH involved in several pathways and played different roles in them. We selected most pathways GZMH participated on our site, such as Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of Angiotensinogen to Angiotensins	ACE;CPB1;ATP6AP2;CTSG;CPB2;CPA3;GZMH;CMA1
Metabolism of proteins	CST3;COX17;GPR116;ATPBD4;IGFBP2B;ZDHHC2;LMAN2L;ARSF;SPCS3
Peptide hormone metabolism	RAB27A;SPCS3;CPA3;CDX2;CMA1;BCHE;CPB2;O3far1;GPR119
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	IGFBP2A;IGFBP6;KLK13;IGFBP1B;PAPPAB;IGFBP1A;IGFBP4;IGFBP6B;PAPPA

GZMH has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMH itself. We selected most functions GZMH had, and list some proteins which have the same functions with GZMH. You can find most of the proteins on our site.

Function	Related Protein
serine-type endopeptidase activity	PRSS1;PRSS41;PCSK9;CTSC;FAP;PRSS27;LPA;KLK1B4;TPP2

GZMH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMH here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMH.

shut_ade05

Granzyme

Cytotoxic T Cells (CTLs)